MolNFT v1 · #146000 · protein
N-GTPase domain of P190RHOGAP-a
6D4G · Rho GTPase-activating protein 35: “N-GTPase domain of P190RHOGAP-a”. X-ray diffraction, 2 ligands (GTP, MG), 5 pockets (best druggability 0.71). MolNFT v1 #146000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6D4G
- Type
- protein
- Length
- 418 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho GTPase-activating protein 35
- UniProt
- P81128
- Ligands
- GTP, MG
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho GTPase-activating protein 35 | protein | 231 | 32% helix, 23% strand | P81128 |
| B | Rho GTPase-activating protein 35 | protein | 187 | 38% helix, 18% strand | P81128 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 535 | 0.71 | 0.80 | 57 | GTP |
| 2 | 257 | 0.59 | 0.79 | 31 | GTP, MG |
| 3 | 187 | 0.55 | 0.79 | 23 | empty |
| 4 | 113 | 0.43 | 0.77 | 20 | empty |
| 5 | 77 | 0.33 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 505 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81128
- Elsewhere: RCSB PDB 6D4G · PDBe 6D4G · UniProt P81128
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