UniProt P78563
Double-stranded RNA-specific editase 1 (P78563)
Double-stranded RNA-specific editase 1 (UniProt P78563), EC 3.5.4.37: 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 124 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P78563
- Protein
- Double-stranded RNA-specific editase 1
- EC
- 3.5.4.37
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 124 · 10 records with a druggable one
Structures
21 records of P78563 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZY7 | Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (hADAR2) bound… | x-ray diffraction | A, B | — | — |
| 1ZY7 | Crystal structure of the catalytic domain of an adenosine deaminase that acts on RNA (HADAR2) bound… | x-ray diffraction | A, B | — | — |
| 5ED1 | Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from… | x-ray diffraction | A, D | IHP, ZN | 15 (best 0.83) |
| 5ED1 | Human adenosine deaminase acting on dsrna (ADAR2) mutant E488Q bound to dsrna sequence derived from… | x-ray diffraction | A, D | — | — |
| 5ED2 | Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from… | x-ray diffraction | A, D | IHP, ZN | — |
| 5ED2 | Human adenosine deaminase acting on dsrna (ADAR2) mutant E488Q bound to dsrna sequence derived from… | x-ray diffraction | A, D | — | — |
| 5HP2 | Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S.… | x-ray diffraction | A, D | IHP, ZN | 13 (best 0.83) |
| 5HP2 | Human adenosine deaminase acting on dsrna (ADAR2) bound to dsrna sequence derived from S.… | x-ray diffraction | A, D | — | — |
| 5HP3 | Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S.… | x-ray diffraction | A, D | IHP, ZN | — |
| 5HP3 | Human adenosine deaminase acting on dsrna (ADAR2) bound to dsrna sequence derived from S.… | x-ray diffraction | A, D | — | — |
| 6D06 | Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base | x-ray diffraction | A, D | IHP, ZN | 14 (best 0.83) |
| 6D06 | Human ADAR2D E488Y mutant complexed with dsrna containing an abasic site opposite the edited base | x-ray diffraction | A, D | IHP, ZN | — |
| 6VFF | Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence… | x-ray diffraction | A, B | IHP, ZN | 10 (best 0.83) |
| 6VFF | Dimer of human adenosine deaminase acting on dsrna (ADAR2) mutant E488Q bound to dsrna sequence… | x-ray diffraction | A, B | IHP, ZN | — |
| 7KFN | Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy… | x-ray diffraction | A, D | IHP, ZN | 11 (best 0.83) |
| 7KFN | Structure of human adenosine deaminase acting on dsrna (ADAR2) bound to dsrna containing a 2'-deoxy… | x-ray diffraction | A, D | IHP, ZN | — |
| 8E0F | Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent… | x-ray diffraction | A, B | IHP, ZN | 11 (best 0.83) |
| 8E4X | Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair… | x-ray diffraction | A, B | IHP, ZN | 15 (best 0.83) |
| 9D5J | Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing deoxyinosine at the… | x-ray diffraction | A, B | IHP, ZN | 13 (best 0.83) |
| 9D5K | Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing an expanded cytidine… | x-ray diffraction | A, B | IHP, ZN, MG | 16 (best 0.82) |
| P78563 | AlphaFold monomer V2.0 prediction for double-stranded RNA-specific editase 1 (P78563) | predicted | A | — | 6 (best 0.84) |
Ligands
Experiment against prediction
- 7KFN chain D against the predicted model P78563: TM-score 1.00, RMSD 0.48 Å
- 7KFN chain D against the predicted model P78563: TM-score 1.00, RMSD 0.48 Å
- 6D06 chain D against the predicted model P78563: TM-score 1.00, RMSD 0.49 Å
- 6D06 chain D against the predicted model P78563: TM-score 1.00, RMSD 0.49 Å
- 1ZY7 chain B against the predicted model P78563: TM-score 0.99, RMSD 0.52 Å
- 1ZY7 chain B against the predicted model P78563: TM-score 0.99, RMSD 0.52 Å
- 1ZY7 chain A against the predicted model P78563: TM-score 0.99, RMSD 0.65 Å
- 1ZY7 chain A against the predicted model P78563: TM-score 0.99, RMSD 0.65 Å
- 6VFF chain B against the predicted model P78563: TM-score 0.99, RMSD 0.77 Å
- 6VFF chain B against the predicted model P78563: TM-score 0.99, RMSD 0.77 Å
Elsewhere
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