UniProt P62937
Peptidyl-prolyl cis-trans isomerase A (P62937)
Peptidyl-prolyl cis-trans isomerase A (UniProt P62937), EC 5.2.1.8: 235 experimental structures on GenesisL1, 35 ligands bound, 25 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P62937
- Protein
- Peptidyl-prolyl cis-trans isomerase A
- EC
- 5.2.1.8
- Experimental structures
- 235
- Predicted models
- 0
- Ligands
- 35
- Pockets
- 25 · 6 records with a druggable one
Structures
235 records of P62937 in the MolNFT archive: 235 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AK4 | Human cyclophilin a bound to the amino-terminal domain of HIV-1 capsid | x-ray diffraction | A, B | — | — |
| 1AK4 | Human cyclophilin a bound to the amino-terminal domain of HIV-1 capsid | x-ray diffraction | A, B | — | — |
| 1AWQ | Cypa complexed with hagpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWQ | Cypa complexed with hagpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWR | Cypa complexed with hagpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AWR | Cypa complexed with hagpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AWS | Secypa complexed with hagpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWS | Secypa complexed with hagpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWT | Secypa complexed with hagpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AWT | Secypa complexed with hagpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AWU | Cypa complexed with hvgpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWU | Cypa complexed with hvgpia (pseudo-symmetric monomer) | x-ray diffraction | A | — | — |
| 1AWV | Cypa complexed with hvgpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AWV | Cypa complexed with hvgpia | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1BCK | Human cyclophilin a complexed with 2-thr cyclosporin | x-ray diffraction | A | — | — |
| 1BCK | Human cyclophilin a complexed with 2-thr cyclosporin | x-ray diffraction | A | — | — |
| 1CWF | Human cyclophilin a complexed with 2-val cyclosporin | x-ray diffraction | A | — | — |
| 1CWF | Human cyclophilin a complexed with 2-val cyclosporin | x-ray diffraction | A | — | — |
| 1CWH | Human cyclophilin a complexed with 3-D-ser cyclosporin | x-ray diffraction | A | — | — |
| 1CWH | Human cyclophilin a complexed with 3-D-ser cyclosporin | x-ray diffraction | A | — | — |
| 1CWI | Human cyclophilin a complexed with 2-val 3-(N-methyl)-D-alanine cyclosporin | x-ray diffraction | A | — | — |
| 1CWI | Human cyclophilin a complexed with 2-val 3-(N-methyl)-D-alanine cyclosporin | x-ray diffraction | A | — | — |
| 1CWM | Human cyclophilin a complexed with 4 meile cyclosporin | x-ray diffraction | A | — | — |
| 1CWM | Human cyclophilin a complexed with 4 meile cyclosporin | x-ray diffraction | A | — | — |
| 1CWO | Human cyclophilin a complexed with THR2, LEU5, D-HIV8, LEU10 cyclosporin | x-ray diffraction | A | — | — |
| 1CWO | Human cyclophilin a complexed with THR2, LEU5, D-HIV8, LEU10 cyclosporin | x-ray diffraction | A | — | — |
| 1FGL | Cyclophilin A complexed with a fragment of HIV-1 GAG protein | x-ray diffraction | A | — | — |
| 1FGL | Cyclophilin a complexed with a fragment of HIV-1 gag protein | x-ray diffraction | A | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | C, G | — | — |
| 1M63 | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of… | x-ray diffraction | C, G | — | — |
| 1M9C | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type Complex. | x-ray diffraction | A, B | — | — |
| 1M9C | X-ray crystal structure of cyclophilin A/HIV-1 ca N- terminal domain (1-146) M-type complex. | x-ray diffraction | A, B | — | — |
| 1M9D | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) O-type chimera Complex. | x-ray diffraction | A, B | — | — |
| 1M9D | X-ray crystal structure of cyclophilin A/HIV-1 ca N-terminal domain (1-146) O-type chimera complex. | x-ray diffraction | A, B | — | — |
| 1M9E | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. | x-ray diffraction | A, B | — | — |
| 1M9E | X-ray crystal structure of cyclophilin A/HIV-1 ca N-terminal domain (1-146) M-type H87A complex. | x-ray diffraction | A, B | — | — |
| 1M9F | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M… | x-ray diffraction | A, B | — | — |
| 1M9F | X-ray crystal structure of cyclophilin A/HIV-1 ca N-terminal domain (1-146) M-type H87A,A88M… | x-ray diffraction | A, B | — | — |
| 1M9X | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,A88M,G89A… | x-ray diffraction | A, B, E, F | — | — |
| 1M9X | X-ray crystal structure of cyclophilin A/HIV-1 ca N-terminal domain (1-146) M-type H87A,A88M,G89A… | x-ray diffraction | A, B, E, F | — | — |
| 1M9Y | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A… | x-ray diffraction | A, B, E, F | — | — |
| 1M9Y | X-ray crystal structure of cyclophilin A/HIV-1 ca N-terminal domain (1-146) M-type H87A,G89A… | x-ray diffraction | A, B, E, F | — | — |
| 1MF8 | Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin | x-ray diffraction | C | — | — |
| 1MF8 | Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin | x-ray diffraction | C | — | — |
| 1NMK | The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray… | x-ray diffraction | A, B | — | — |
| 1NMK | The sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray… | x-ray diffraction | A, B | — | — |
| 1OCA | Human cyclophilin a, unligated, NMR, 20 structures | solution nmr | A | — | — |
| 1W8L | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes | x-ray diffraction | A | — | — |
| 1W8L | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes | x-ray diffraction | A | — | — |
| 1W8M | Enzymatic and Structural Characterisation of Non Peptide Ligand Cyclophilin Complexes | x-ray diffraction | A | — | — |
| 1W8M | Enzymatic and structural characterisation of non peptide ligand cyclophilin complexes | x-ray diffraction | A | — | — |
| 1W8V | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes | x-ray diffraction | A | — | — |
| 1W8V | Enzymatic and structural characterization of non peptide ligand cyclophilin complexes | x-ray diffraction | A | — | — |
| 1YND | Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6A… | x-ray diffraction | A, B | — | — |
| 1YND | Structure of human cyclophilin a in complex with the novel immunosuppressant sanglifehrin a at 1.6A… | x-ray diffraction | A, B | — | — |
| 1ZKF | Cyrstal Structure of Human Cyclophilin-A in Complex with suc-AGPF-pNA | x-ray diffraction | A, B | — | — |
| 1ZKF | Cyrstal structure of human cyclophilin-a in complex with suc-agpf-pna | x-ray diffraction | A, B | — | — |
| 2ALF | crystal structure of human CypA mutant K131A | x-ray diffraction | A | — | — |
| 2ALF | Crystal structure of human cypa mutant K131A | x-ray diffraction | A | — | — |
| 2CPL | Similarities and differences between human cyclophilin a and other beta-barrel structures.… | x-ray diffraction | A | — | — |
175 records more on the page itself.
Ligands
- L36 · ethyl 2-[[(4-aminophenyl)methyl-propyl-carbamoyl]amino]ethanoate · in 4 records
- ZNI · (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide · in 4 records
- UMM · Tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1, 21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate · in 3 records
- 93B · 1,3-diazinane-2-thione · in 2 records
- 93E · 3-chloranylpyridin-2-amine · in 2 records
- 93K · 3,4-bis(azanyl)benzamide · in 2 records
- F0Q · 1-[(4-aminophenyl)methyl]-3-[2-[(2~{R})-2-(2-bromophenyl)pyrrolidin-1-yl]-2-oxidanylidene-ethyl]-1-[(2-methyl-1,2,3,4-tetrazol-5-yl)methyl]urea · in 2 records
- F0T · Ethyl 2-[[(4-aminophenyl)methyl-(cyclopropylmethyl) carbamoyl]amino]ethanoate · in 2 records
- F0W · ethyl 2-[[(4-aminophenyl)methyl-[(2-methyl-1,2,3,4-tetrazol-5-yl)methyl]carbamoyl]amino]ethanoate · in 2 records
- F1Q · ethyl 2-[[(4-aminophenyl)methyl-(1~{H}-1,2,3,4-tetrazol-5-ylmethyl)carbamoyl]amino]ethanoate · in 2 records
- F1Z · ethyl 2-[[(4-aminophenyl)methyl-prop-2-ynyl-carbamoyl]amino]ethanoate · in 2 records
- L60 · 1,3-diazinan-2-one · in 2 records
- L89 · pyridine-3,4-diamine · in 2 records
- L99 · 3,4-bis(azanyl)benzohydrazide · in 2 records
- UOG · (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone · in 2 records
- 78E · 3-[(3-hydroxyphenyl)methyl]-6-(propan-2-yl)-19-oxa-1,4, 7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5, 8,20-tetrone · in 1 record
- 78R · 11-[(3-hydroxyphenyl)methyl]-18-methoxy-17-methyl-14-(propan-2-yl)-3-oxa-9,12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23, 25-tetraene-4,10,13,16-tetrone · in 1 record
- 78X · 11-[(3-hydroxyphenyl)methyl]-18-methoxy-2,17-dimethyl-14-(propan-2-yl)-3-oxa-9,12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23, 25-tetraene-4,10,13,16-tetrone · in 1 record
- 7HG · 3-[(3-hydroxyphenyl)methyl]-10,12-dimethoxy-9,11-dimethyl-6-(propan-2-yl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone · in 1 record
- 7I7 · N-[2-[2-[2-(2-formamidoethoxy)ethoxy]ethoxy]ethyl]-3-sulfanyl-propanamide · in 1 record
- 7IB · 8-azanyl-5-(4-oxidanyl-4-oxidanylidene-butyl)quinoline-2-carboxylic acid · in 1 record
- 838 · 18-methoxy-2,11,17-trimethyl-14-(propan-2-yl)-3-oxa-9, 12,15,28-tetraazatricyclo[21.3.1.1~5,9~]octacosa-1(27),21,23,25-tetraene-4,10,13,16-tetrone · in 1 record
- 92Z · 5-azanyl-3~{H}-pyridin-6-one · in 1 record
- 938 · 4-chloranylpyrimidin-5-amine · in 1 record
- 93Q · 3-methylpyridin-2-amine · in 1 record
- CL · Chloride ion · in 1 record
- F1E · Ethyl 2-[[(4-aminophenyl)methyl-[(1-methyl-1,2,3-triazol-4-yl)methyl]carbamoyl]amino]ethanoate · in 1 record
- L97 · 2-chloranylpyridin-3-amine · in 1 record
- QUK · 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Elsewhere
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