UniProt P61823
ribonuclease pancreatic (P61823)
ribonuclease pancreatic (UniProt P61823), EC 3.1.27.5, 4.6.1.18: 618 experimental structures and 1 predicted model on GenesisL1, 129 ligands bound, 438 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P61823
- Protein
- ribonuclease pancreatic
- EC
- 3.1.27.5, 4.6.1.18
- Experimental structures
- 618
- Predicted models
- 1
- Ligands
- 129
- Pockets
- 438 · 38 records with a druggable one
Structures
619 records of P61823 in the MolNFT archive: 618 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A2W | Crystal structure of a 3D domain-swapped dimer of bovine pancreatic ribonuclease a | x-ray diffraction | A, B | CL, SO4 | — |
| 1A2W | Crystal structure of a 3D domain-swapped dimer of bovine pancreatic ribonuclease a | x-ray diffraction | A, B | CL, SO4 | — |
| 1A5P | C[40,95]A variant of bovine pancreatic ribonuclease a | x-ray diffraction | A | SO4 | — |
| 1A5P | C[40,95]A variant of bovine pancreatic ribonuclease a | x-ray diffraction | A | SO4 | — |
| 1A5Q | P93A variant of bovine pancreatic ribonuclease a | x-ray diffraction | A | SO4 | — |
| 1A5Q | P93A variant of bovine pancreatic ribonuclease a | x-ray diffraction | A | SO4 | — |
| 1AFK | Crystal structure of ribonuclease a in complex with 5'-diphosphoadenosine-3'-phosphate | x-ray diffraction | A, B | PAP | 2 (best 0.48) |
| 1AFK | Crystal structure of ribonuclease a in complex with 5'- diphosphoadenosine-3'-phosphate | x-ray diffraction | A, B | PAP | 2 (best 0.48) |
| 1AFL | Ribonuclease a in complex with 5'-diphosphoadenosine 2'-phosphate at 1.7 ångström resolution | x-ray diffraction | A, B | ATR | 2 (best 0.50) |
| 1AFL | Ribonuclease a in complex with 5'-diphosphoadenosine 2'- phosphate at 1.7 ångström resolution | x-ray diffraction | A, B | ATR | 2 (best 0.50) |
| 1AFU | Structure of ribonuclease a at 2.0 ångströms from monoclinic crystals | x-ray diffraction | A, B | — | 1 (best 0.50) |
| 1AFU | Structure of ribonuclease a at 2.0 ångströms from monoclinic crystals | x-ray diffraction | A, B | — | 1 (best 0.50) |
| 1AQP | Ribonuclease a copper complex | x-ray diffraction | A | CU | — |
| 1AQP | Ribonuclease a copper complex | x-ray diffraction | A | CU | — |
| 1B6V | Crystal structure of a hybrid between ribonuclease a and bovine seminal ribonuclease | x-ray diffraction | A, B | — | 1 (best 0.31) |
| 1B6V | Crystal structure of a hybrid between ribonuclease a and bovine seminal ribonuclease | x-ray diffraction | A, B | — | 1 (best 0.31) |
| 1BEL | Hydrolase phosphoric diester, RNA | x-ray diffraction | A | SO4 | — |
| 1BEL | Hydrolase phosphoric diester, RNA | x-ray diffraction | A | SO4 | — |
| 1BZQ | Complex of a dromedary single-domain vhh antibody fragment with RNase a | x-ray diffraction | A, B, C, D | PO4 | 8 (best 0.71) |
| 1BZQ | Complex of a dromedary single-domain vhh antibody fragment with RNase a | x-ray diffraction | A, B, C, D | PO4 | 8 (best 0.71) |
| 1C0B | Bovine pancreatic ribonuclease a desiccated for 2.5 days | x-ray diffraction | A | SO4 | — |
| 1C0B | Bovine pancreatic ribonuclease a desiccated for 2.5 days | x-ray diffraction | A | SO4 | — |
| 1C0C | Bovine pancreatic ribonuclease a desiccated for 4.0 days | x-ray diffraction | A | SO4 | — |
| 1C0C | Bovine pancreatic ribonuclease a desiccated for 4.0 days | x-ray diffraction | A | SO4 | — |
| 1C8W | THR45GLY variant of ribonuclease a | x-ray diffraction | A | CL | 1 (best 0.31) |
| 1C8W | THR45GLY variant of ribonuclease a | x-ray diffraction | A | CL | 1 (best 0.31) |
| 1C9V | H12A variant of ribonuclease a | x-ray diffraction | A | CL | — |
| 1C9V | H12A variant of ribonuclease a | x-ray diffraction | A | CL | — |
| 1C9X | H119A variant of ribonuclease a | x-ray diffraction | A | CL | — |
| 1C9X | H119A variant of ribonuclease a | x-ray diffraction | A | CL | — |
| 1CJQ | X-ray crystallographic studies of the denaturation of the denaturation of ribonuclease S. | x-ray diffraction | A, B | SO4 | 1 (best 0.25) |
| 1CJQ | X-ray crystallographic studies of the denaturation of the denaturation of ribonuclease S. | x-ray diffraction | A, B | SO4 | 1 (best 0.25) |
| 1CJR | X-ray crystallographic studies of denaturation in ribonuclease S | x-ray diffraction | A, B | SO4 | — |
| 1CJR | X-ray crystallographic studies of denaturation in ribonuclease S | x-ray diffraction | A, B | SO4 | — |
| 1D5D | The role of phenylalanine 8 in the stabilization of the s protein-s peptide interaction: packing… | x-ray diffraction | A | SO4 | — |
| 1D5D | The role of phenylalanine 8 in the stabilization of the S protein-S peptide interaction: packing… | x-ray diffraction | A | SO4 | — |
| 1D5E | The role of phenylalanine 8 in the stabilization of the S protein-S peptide interaction: Packing… | x-ray diffraction | A | SO4 | — |
| 1D5E | The role of phenylalanine 8 in the stabilization of the S protein-S peptide interaction: packing… | x-ray diffraction | A | SO4 | — |
| 1D5H | Rnase s(f8a). mutant ribonucleasE S. | x-ray diffraction | A | SO4 | — |
| 1D5H | RNase S(F8A). mutant ribonuclease S. | x-ray diffraction | A | SO4 | — |
| 1DFJ | Ribonuclease inhibitor complexed with ribonuclease a | x-ray diffraction | E | SO4 | 2 (best 0.76) |
| 1DFJ | Ribonuclease inhibitor complexed with ribonuclease a | x-ray diffraction | E | SO4 | 2 (best 0.76) |
| 1DY5 | Deamidated derivative of bovine pancreatic ribonuclease | x-ray diffraction | A, B | SO4 | 2 (best 0.43) |
| 1DY5 | Deamidated derivative of bovine pancreatic ribonuclease | x-ray diffraction | A, B | SO4 | 2 (best 0.43) |
| 1EIC | Crystal structure of F120A mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | 1 (best 0.41) |
| 1EIC | Crystal structure of F120A mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | 1 (best 0.41) |
| 1EID | Crystal structure of F120G mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | 1 (best 0.41) |
| 1EID | Crystal structure of F120G mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | 1 (best 0.41) |
| 1EIE | Crystal structure of F120W mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | — |
| 1EIE | Crystal structure of F120W mutant of bovine pancreatic ribonuclease a | x-ray diffraction | A | — | — |
| 1EOS | Crystal structure of ribonuclease a complexed with URIDYLYL(2',5')GUANOSINE (productive binding) | x-ray diffraction | A, B | U2G | 3 (best 0.34) |
| 1EOS | Crystal structure of ribonuclease a complexed with URIDYLYL(2',5')GUANOSINE (productive binding) | x-ray diffraction | A, B | U2G | 3 (best 0.34) |
| 1EOW | Crystal structure of ribonuclease a complexed with URIDYLYL(2',5')GUANOSINE (non-productive binding) | x-ray diffraction | A | SO4, U2G | — |
| 1EOW | Crystal structure of ribonuclease a complexed with URIDYLYL(2',5')GUANOSINE (non-productive binding) | x-ray diffraction | A | SO4, U2G | — |
| 1F0V | Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping | x-ray diffraction | A, B, C, D | PO4 | 1 (best 0.30) |
| 1F0V | Crystal structure of an RNase a dimer displaying a new type of 3D domain swapping | x-ray diffraction | A, B, C, D | PO4 | 1 (best 0.30) |
| 1FEV | Crystal structure of the ALA4AIB mutation in RNase S | x-ray diffraction | A, B | SO4 | — |
| 1FEV | Crystal structure of the ALA4AIB mutation in RNase S | x-ray diffraction | A, B | SO4 | — |
| 1FS3 | Crystal structure of wild-type bovine pancreatic ribonuclease a | x-ray diffraction | A | — | — |
| 1FS3 | Crystal structure of wild-type bovine pancreatic ribonuclease a | x-ray diffraction | A | — | — |
559 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 163 records
- CL · Chloride ion · in 73 records
- PO4 · Phosphate ion · in 21 records
- NH2 · Amino group · in 11 records
- NA · Sodium ion · in 9 records
- AMP · Adenosine monophosphate · in 7 records
- F3I · (mi2-acetato-O, O')-hexaaquo-dirhodium (II) · in 7 records
- 9Q8 · tris(oxidaniumylidynemethyl)-tris(oxidanyl)ruthenium · in 6 records
- CS · Cesium ion · in 6 records
- C3P · Cytidine-3'-monophosphate · in 5 records
- CGP · 2'-deoxycytidine-2'-deoxyguanosine-3',5'-monophosphate · in 5 records
- D1O · tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) · in 5 records
- F5I · cis-bis(mi2-acetato-O, O')-tetraaquo-dirhodium(II) · in 5 records
- F5T · cis-bis(mi2-acetato-O, O')-(mi2-trifluoroacetato-O, O')-diaquo-dirhodium (II) · in 5 records
- PT · Platinum (II) ion · in 5 records
- VVU · dirhodium (II) tetraacetate · in 5 records
- AEN · 5-(1-sulfonaphthyl)-acetylamino-ethylamine · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- C2P · Cytidine-2'-monophosphate · in 4 records
- C5P · Cytidine-5'-monophosphate · in 4 records
- DGP · 2'-deoxyguanosine-5'-monophosphate · in 4 records
- RU2 · pentakis(oxidaniumyl)-(oxidaniumylidynemethyl)ruthenium · in 4 records
- SFB · (2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-[[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]methylsulfonyl]-3,4-dihydroxy-oxolane-2-carboxamide · in 4 records
- U2G · Uridylyl-2'-5'-phospho-guanosine · in 4 records
- U3P · 3'-uridinemonophosphate · in 4 records
- UVC · Uridine-2',3'-vanadate · in 4 records
- AU · Gold ion · in 3 records
- QPT · carboplatin · in 3 records
- 139 · Adenosine-5'-[trihydrogen diphosphate] P'-3'-ester with 2'-deoxyuridine · in 2 records
- 5FA · Adenosine-5'-pentaphosphate · in 2 records
Experiment against prediction
- 1RAT chain A against the predicted model P61823: TM-score 0.99, RMSD 0.30 Å
- 1RHB chain A against the predicted model P61823: TM-score 0.99, RMSD 0.32 Å
- 1BZQ chain A against the predicted model P61823: TM-score 0.99, RMSD 0.32 Å
- 1RBX chain A against the predicted model P61823: TM-score 0.99, RMSD 0.34 Å
- 1RBW chain A against the predicted model P61823: TM-score 0.99, RMSD 0.34 Å
- 1AFL chain A against the predicted model P61823: TM-score 0.99, RMSD 0.34 Å
- 1AFK chain A against the predicted model P61823: TM-score 0.99, RMSD 0.34 Å
- 1RND chain A against the predicted model P61823: TM-score 0.99, RMSD 0.34 Å
- 1KF3 chain A against the predicted model P61823: TM-score 0.99, RMSD 0.36 Å
- 1KF5 chain A against the predicted model P61823: TM-score 0.99, RMSD 0.36 Å
Elsewhere
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