UniProt P61086
Ubiquitin-conjugating enzyme E2 K (P61086)
Ubiquitin-conjugating enzyme E2 K (UniProt P61086), EC 2.3.2.23: 25 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P61086
- Protein
- Ubiquitin-conjugating enzyme E2 K
- EC
- 2.3.2.23
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 2 records with a druggable one
Structures
26 records of P61086 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YLA | Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2) | x-ray diffraction | A, B | — | — |
| 1YLA | Ubiquitin-conjugating enzyme E2-25 kda (huntington interacting protein 2) | x-ray diffraction | A, B | — | — |
| 2O25 | Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9 | x-ray diffraction | A, B | — | — |
| 2O25 | Ubiquitin-conjugating enzyme E2-25 kda complexed with sumo-1- conjugating enzyme UBC9 | x-ray diffraction | A, B | — | — |
| 3E46 | Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A… | x-ray diffraction | A | — | — |
| 3E46 | Crystal structure of ubiquitin-conjugating enzyme E2-25KDA (huntington interacting protein 2) M172A… | x-ray diffraction | A | — | — |
| 3F92 | Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington Interacting Protein 2) M172A… | x-ray diffraction | A | — | — |
| 3F92 | Crystal structure of ubiquitin-conjugating enzyme E2-25KDA (huntington interacting protein 2) M172A… | x-ray diffraction | A | — | — |
| 3K9O | The crystal structure of E2-25K and UBB+1 complex | x-ray diffraction | A | — | — |
| 3K9O | The crystal structure of E2-25K and UBB+1 complex | x-ray diffraction | A | — | — |
| 3K9P | The crystal structure of E2-25K and ubiquitin complex | x-ray diffraction | A | — | — |
| 3K9P | The crystal structure of E2-25K and ubiquitin complex | x-ray diffraction | A | — | — |
| 5DFL | Crystal structure of UBE2K~UBIQUITIN conjugate | x-ray diffraction | A | — | — |
| 6IF1 | Crystal structure of Ube2K and K48-linked di-ubiquitin complex | x-ray diffraction | A, B | — | 2 (best 0.69) |
| 6IF1 | Crystal structure of UBE2K and K48-linked di-ubiquitin complex | x-ray diffraction | A, B | — | — |
| 6JB6 | Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution | x-ray diffraction | A | — | — |
| 6JB6 | Crystal structure of ub-conjugated UBE2K C92K&K97A mutant (isopeptide linkage), 2.7 a resolution | x-ray diffraction | A | — | — |
| 6JB7 | Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution | x-ray diffraction | A | — | — |
| 6JB7 | Crystal structure of ub-conjugated UBE2K C92K&K97A mutant (isopeptide linkage), 2.1 a resolution | x-ray diffraction | A | — | — |
| 7MYF | Ubiquitin variant UbV.k.1 in complex with Ube2k | x-ray diffraction | A | — | 1 (best 0.29) |
| 7MYF | Ubiquitin variant UBV.K.1 in complex with UBE2K | x-ray diffraction | A | — | — |
| 7MYH | Ubiquitin variant UbV.k.2 in complex with Ube2k | x-ray diffraction | A | — | — |
| 7MYH | Ubiquitin variant UBV.K.2 in complex with UBE2K | x-ray diffraction | A | — | — |
| 7OJX | E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain… | x-ray diffraction | B | ME7 | 5 (best 0.60) |
| 7OJX | E2 UBE2K covalently linked to donor ub, acceptor di-ub, and ring E3 primed for K48-linked ub chain… | x-ray diffraction | B | ME7 | — |
| P61086 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 K (P61086) | predicted | A | — | — |
Ligands
- ME7 · 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione) · in 2 records
Experiment against prediction
- 3F92 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.25 Å
- 3F92 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.25 Å
- 3E46 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.29 Å
- 3E46 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.29 Å
- 6IF1 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.46 Å
- 6IF1 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.46 Å
- 7MYH chain A against the predicted model P61086: TM-score 0.99, RMSD 0.54 Å
- 7MYH chain A against the predicted model P61086: TM-score 0.99, RMSD 0.54 Å
- 2O25 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.60 Å
- 2O25 chain A against the predicted model P61086: TM-score 0.99, RMSD 0.60 Å
Elsewhere
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