MolNFT v1 · #68897 · protein

The crystal structure of E2-25K and UBB+1 complex

3K9O · Ubiquitin-conjugating enzyme E2 K: “The crystal structure of E2-25K and UBB+1 complex”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #68897 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3K9O
Type: protein
Length: 273 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2 K; Ubiquitin
EC: 6.3.2.19
UniProt: P61086
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-conjugating enzyme E2 K (EC 6.3.2.19)	protein	198	44% helix, 14% strand	P61086
B	Ubiquitin	protein	75	24% helix, 35% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.30	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 462 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3K9O · The crystal structure of E2-25K and UBB+1 complex · the same entry in another collection · chain A against A, TM-score 1.00
P61086 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 K (P61086) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61086
Elsewhere: RCSB PDB 3K9O · PDBe 3K9O · UniProt P61086

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