UniProt P60174
Triosephosphate isomerase (P60174)
Triosephosphate isomerase (UniProt P60174), EC 4.2.3.3, 5.3.1.1: 39 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P60174
- Protein
- Triosephosphate isomerase
- EC
- 4.2.3.3, 5.3.1.1
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 30 · 3 records with a druggable one
Structures
40 records of P60174 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HTI | Crystal structure of recombinant human triosephosphate isomerase at 2.8 ångströms resolution.… | x-ray diffraction | A, B | — | — |
| 1HTI | Crystal structure of recombinant human triosephosphate isomerase at 2.8 ångströms resolution.… | x-ray diffraction | A, B | — | — |
| 1WYI | human triosephosphate isomerase of new crystal form | x-ray diffraction | A, B | — | — |
| 1WYI | Human triosephosphate isomerase of new crystal form | x-ray diffraction | A, B | — | — |
| 2IAM | Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR | x-ray diffraction | P | — | — |
| 2IAM | Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR | x-ray diffraction | P | — | — |
| 2IAN | Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR | x-ray diffraction | C, H, M, R | — | — |
| 2IAN | Structural basis for recognition of mutant self by a tumor- specific, MHC class II-restricted TCR | x-ray diffraction | C, H, M, R | — | — |
| 2JK2 | Structural basis of human triosephosphate isomerase deficiency. crystal structure of the wild type… | x-ray diffraction | A, B | — | — |
| 2JK2 | Structural basis of human triosephosphate isomerase deficiency. crystal structure of the wild type… | x-ray diffraction | A, B | — | — |
| 2VOM | Structural basis of human triosephosphate isomerase deficiency. Mutation E104D and correlation to… | x-ray diffraction | A, B, C, D | — | — |
| 2VOM | Structural basis of human triosephosphate isomerase deficiency. mutation E104D and correlation to… | x-ray diffraction | A, B, C, D | — | — |
| 4BR1 | Protease-induced heterodimer of human triosephosphate isomerase. | x-ray diffraction | A, B | — | — |
| 4BR1 | Protease-induced heterodimer of human triosephosphate isomerase. | x-ray diffraction | A, B | — | — |
| 4E41 | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T… | x-ray diffraction | C, H | — | — |
| 4E41 | Structural basis for the recognition of mutant self by a tumor- specific, MHC class II-restricted T… | x-ray diffraction | C, H | — | — |
| 4POC | Structure of Triosephosphate Isomerase Wild Type human enzyme. | x-ray diffraction | A, B | — | — |
| 4POC | Structure of triosephosphate isomerase wild type human enzyme. | x-ray diffraction | A, B | — | — |
| 4POD | Structure of Triosephosphate Isomerase I170V mutant human enzyme. | x-ray diffraction | A, B | — | — |
| 4POD | Structure of triosephosphate isomerase I170V mutant human enzyme. | x-ray diffraction | A, B | — | — |
| 4UNK | Crystal structure of human triosephosphate isomerase (mutant N15D) | x-ray diffraction | A, B | — | — |
| 4UNK | Crystal structure of human triosephosphate isomerase (mutant N15D) | x-ray diffraction | A, B | — | — |
| 4UNL | Crystal structure of a single mutant (N71D) of triosephosphate isomerase from human | x-ray diffraction | A, B | — | — |
| 4UNL | Crystal structure of a single mutant (N71D) of triosephosphate isomerase from human | x-ray diffraction | A, B | — | — |
| 4ZVJ | Structure of human triose phosphate isomerase K13M | x-ray diffraction | A, B | NA, K | 2 (best 0.47) |
| 4ZVJ | Structure of human triose phosphate isomerase K13M | x-ray diffraction | A, B | — | — |
| 6C2G | Human triosephosphate isomerase mutant V231M | x-ray diffraction | A, B, C, D | — | — |
| 6C2G | Human triosephosphate isomerase mutant V231M | x-ray diffraction | A, B, C, D | — | — |
| 6D43 | Characterization of human triosephosphate isomerase S-nitrosylation | x-ray diffraction | A, B | — | — |
| 6NLH | Structure of human triose phosphate isomerase R189A | x-ray diffraction | A, E, B, C, D, F, G, H | NA, BR, PO4 | 17 (best 0.80) |
| 6NLH | Structure of human triose phosphate isomerase R189A | x-ray diffraction | A, E, B, C, D, F, G, H | NA, BR, PO4 | — |
| 6UP1 | Triosephosphate isomerase deficiency: effect of F240L mutation on enzyme structure | x-ray diffraction | A, B | — | — |
| 6UP5 | Triosephosphate isomerase deficiency: effect of F240L mutation on enzyme structure | x-ray diffraction | A, B | PGA | — |
| 6UP8 | Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure | x-ray diffraction | A, B | — | 4 (best 0.70) |
| 6UP8 | Triosephosphate isomerase deficiency: effect of F240L mutation on enzyme structure | x-ray diffraction | A, B | — | — |
| 6UPF | Triosephosphate isomerase deficiency: effect of F240L mutation on enzyme structure | x-ray diffraction | A, B | PGA | — |
| 7RDE | Human Triose Phosphate Isomerase Q181P | x-ray diffraction | A, B | BR, CA | 1 (best 0.44) |
| 7RDE | Human triose phosphate isomerase Q181P | x-ray diffraction | A, B | BR, CA | — |
| 7UXV | human triosephosphate isomerase mutant G122R | x-ray diffraction | A, B | PGA | 4 (best 0.69) |
| P60174 | AlphaFold monomer V2.0 prediction for triosephosphate isomerase (P60174) | predicted | A | — | 2 (best 0.39) |
Ligands
Experiment against prediction
- 6UPF chain A against the predicted model P60174: TM-score 1.00, RMSD 0.37 Å
- 6UP5 chain B against the predicted model P60174: TM-score 1.00, RMSD 0.38 Å
- 4POC chain B against the predicted model P60174: TM-score 1.00, RMSD 0.40 Å
- 4POC chain B against the predicted model P60174: TM-score 1.00, RMSD 0.40 Å
- 4POD chain B against the predicted model P60174: TM-score 0.99, RMSD 0.42 Å
- 4POD chain B against the predicted model P60174: TM-score 0.99, RMSD 0.42 Å
- 7RDE chain B against the predicted model P60174: TM-score 0.99, RMSD 0.43 Å
- 7RDE chain B against the predicted model P60174: TM-score 0.99, RMSD 0.43 Å
- 6NLH chain F against the predicted model P60174: TM-score 0.99, RMSD 0.45 Å
- 6NLH chain E against the predicted model P60174: TM-score 0.99, RMSD 0.45 Å
Elsewhere
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