UniProt P56373
P2X purinoceptor 3 (P56373)
P2X purinoceptor 3 (UniProt P56373): 18 experimental structures on GenesisL1, 11 ligands bound, 13 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P56373
- Protein
- P2X purinoceptor 3
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 13 · 0 records with a druggable one
Structures
18 records of P56373 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5SVJ | Crystal structure of the ATP-gated human P2X3 ion channel in the closed, apo state | x-ray diffraction | A | NAG, MG, NA | — |
| 5SVK | Crystal structure of the ATP-gated human P2X3 ion channel in the ATP- bound, open state | x-ray diffraction | A, B | GLC, ATP, NAG, MHA | — |
| 5SVL | Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed (desensitized)… | x-ray diffraction | A, B | GLC, ATP, NAG, NA | 3 (best 0.38) |
| 5SVL | Crystal structure of the ATP-gated human P2X3 ion channel in the ATP- bound, closed (desensitized)… | x-ray diffraction | A, B | GLC, ATP, NAG, NA | — |
| 5SVM | Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the… | x-ray diffraction | A, B | NAG, 6AT, NA, ATP | 4 (best 0.34) |
| 5SVM | Crystal structure of the ATP-gated human P2X3 ion channel bound to agonist 2-methylthio-ATP in the… | x-ray diffraction | A, B | NAG, 6AT, NA, ATP | — |
| 5SVP | Anomalous sulfur signal reveals the position of agonist 2-methylthio- ATP bound to the ATP-gated… | x-ray diffraction | A, B | NAG, 6AT, NA, ATP | — |
| 5SVQ | Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP | x-ray diffraction | A | NAG, NA, MG, 128 | 2 (best 0.33) |
| 5SVQ | Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist tnp-ATP | x-ray diffraction | A | NAG, NA, MG, 128 | — |
| 5SVR | Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist a-317491 | x-ray diffraction | A | NAG, MG, NA, 71C | — |
| 5SVS | Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated… | x-ray diffraction | A | NAG, MG, NA | 2 (best 0.34) |
| 5SVS | Anomalous MN2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated… | x-ray diffraction | A | NAG, MG, NA | — |
| 5SVT | Anomalous Cs+ signal reveals the site of Na+ ion entry to the channel pore of the human P2X3 ion… | x-ray diffraction | A | NAG, MG, NA | 2 (best 0.34) |
| 5SVT | Anomalous cs+ signal reveals the site of na+ ion entry to the channel pore of the human P2X3 ion… | x-ray diffraction | A | NAG, MG, NA | — |
| 5YVE | Crystal structure of human P2X3 receptor in complex with the af-219 negative allosteric modulator | x-ray diffraction | A | MG, NAG, AF9 | — |
| 6AH4 | Structure of human P2X3 receptor in complex with ATP and CA2+ ion | x-ray diffraction | A, B, C | GLC, ATP, NAG, CA | — |
| 6AH5 | Structure of human P2X3 receptor in complex with ATP and MG2+ ion | x-ray diffraction | A, B, C | GLC, ATP, NAG, MG | — |
| P56373 | AlphaFold monomer V2.0 prediction for P2X purinoceptor 3 (P56373) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- NA · Sodium ion · in 13 records
- MG · Magnesium ion · in 10 records
- ATP · Adenosine-5'-triphosphate · in 8 records
- GLC · alpha-D-glucopyranose · in 5 records
- 6AT · 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate) · in 3 records
- 128 · Spiro(2,4,6-trinitrobenzene[1,2a]-2O',3O'-methylene-adenine-triphosphate · in 2 records
- 71C · 5-{[(3-phenoxyphenyl)methyl][(1s)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}benzene-1,2,4-tricarboxylic acid · in 1 record
- AF9 · 5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide · in 1 record
- CA · Calcium ion · in 1 record
- MHA · (carbamoylmethyl-carboxymethyl-amino)-acetic acid · in 1 record
Elsewhere
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