MolNFT v1 · #134153 · protein
Anomalous sulfur signal reveals the position of agonist 2-methylthio- ATP bound to the ATP-gated human P2X3 ion channel in the desensitized state
5SVP: “Anomalous sulfur signal reveals the position of agonist 2-methylthio- ATP bound to the ATP-gated human P2X3…”. X-ray diffraction, 4 ligands (6AT, ATP, NAG). MolNFT v1 #134153 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5SVP
- Type
- protein
- Length
- 643 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P56373
- Ligands
- 6AT, ATP, NAG, NA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 323 | — | P56373 |
| B | — | protein | 320 | — | P56373 |
Ligands and binding sites
- 6AT · 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate) · ligand · chains A
- ATP · Adenosine-5'-triphosphate · ligand · chains B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P56373 · AlphaFold monomer V2.0 prediction for P2X purinoceptor 3 (P56373) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56373
- Elsewhere: RCSB PDB 5SVP · PDBe 5SVP · UniProt P56373
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