Crystal structure of the ATP-gated human P2X3 ion channel in the ATP- bound, closed (desensitized) state

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
• GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
• NA · Sodium ion · metal · 3 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 6 copies · chains A, B
• ACT · Acetate ion · additive · 3 copies · chains A, B
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5SVL · Crystal structure of the ATP-gated human P2X3 ion channel in the ATP-bound, closed… · the same entry in another collection · chain A against A, TM-score 1.00
• P56373 · AlphaFold monomer V2.0 prediction for P2X purinoceptor 3 (P56373) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P56373
• Elsewhere: RCSB PDB 5SVL · PDBe 5SVL · UniProt P56373