UniProt P53597
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (P53597)
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (UniProt P53597), EC 6.2.1.4, 6.2.1.5: 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 12 pockets. Binding sites, druggability…
- UniProt
- P53597
- Protein
- Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
- EC
- 6.2.1.4, 6.2.1.5
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 12 · 3 records with a druggable one
Structures
6 records of P53597 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G4Q | Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1- SUCLA2 | x-ray diffraction | A | — | — |
| 6WCV | Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | TUY | 4 (best 0.78) |
| 6WCV | Tartryl-CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | TUY | — |
| 7MSR | Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinyl-phosphate, magnesium ion… | x-ray diffraction | A | DCA, MG, ZNS | 3 (best 0.78) |
| 8Z02 | CoA bound to human GTP-specific succinyl-CoA synthetase | x-ray diffraction | A | COA, PO4 | 4 (best 0.80) |
| P53597 | AlphaFold monomer V2.0 prediction for succinate--CoA ligase [ADP/GDP- forming] subunit alpha… | predicted | A | — | 1 (best 0.46) |
Ligands
- TUY · (3S,5S,9R,20R,21R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,20, 21-pentahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphadocosan-22-oic acid 3,5-dioxide (non-preferred name) · in 2 records
- COA · Coenzyme A · in 1 record
- DCA · Desulfo-coenzyme A · in 1 record
- MG · Magnesium ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- ZNS · 4-oxo-4-(phosphonooxy)butanoic acid · in 1 record
Experiment against prediction
- 6G4Q chain A against the predicted model P53597: TM-score 1.00, RMSD 0.41 Å
- 6WCV chain A against the predicted model P53597: TM-score 0.99, RMSD 0.41 Å
- 6WCV chain A against the predicted model P53597: TM-score 0.99, RMSD 0.41 Å
- 7MSR chain A against the predicted model P53597: TM-score 0.99, RMSD 0.50 Å
- 8Z02 chain A against the predicted model P53597: TM-score 0.98, RMSD 0.95 Å
Elsewhere
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