UniProt P52917
Vacuolar protein sorting-associated protein 4,Protein hcp1 (P52917)
Vacuolar protein sorting-associated protein 4,Protein hcp1 (UniProt P52917): 30 experimental structures on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P52917
- Protein
- Vacuolar protein sorting-associated protein 4,Protein hcp1
- Experimental structures
- 30
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 40 · 2 records with a druggable one
Structures
30 records of P52917 in the MolNFT archive: 30 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QP9 | Crystal Structure of S.cerevisiae Vps4 | x-ray diffraction | X | — | — |
| 2QP9 | Crystal structure of S.CEREVISIAE VPS4 | x-ray diffraction | X | — | — |
| 2QPA | Crystal Structure of S.cerevisiae Vps4 in the presence of ADP | x-ray diffraction | A, B, C | — | — |
| 2QPA | Crystal structure of S.CEREVISIAE VPS4 in the presence of ADP | x-ray diffraction | A, B, C | — | — |
| 2RKO | Crystal Structure of the Vps4p-dimer | x-ray diffraction | A | — | — |
| 2RKO | Crystal structure of the VPS4P-dimer | x-ray diffraction | A | — | — |
| 2V6X | Stractural insight into the interaction between ESCRT-III and Vps4 | x-ray diffraction | A | — | — |
| 2V6X | Stractural insight into the interaction between escrt-III and VPS4 | x-ray diffraction | A | — | — |
| 3EIE | Crystal Structure of S.cerevisiae Vps4 in the SO4-bound state | x-ray diffraction | A | — | — |
| 3EIE | Crystal structure of S.CEREVISIAE VPS4 in the SO4-bound state | x-ray diffraction | A | — | — |
| 3EIH | Crystal structure of S.cerevisiae Vps4 in the presence of ATPgammaS | x-ray diffraction | A, B, C | — | — |
| 3EIH | Crystal structure of S.CEREVISIAE VPS4 in the presence of atpgammas | x-ray diffraction | A, B, C | — | — |
| 3MHV | Crystal Structure of Vps4 and Vta1 | x-ray diffraction | C | — | — |
| 3MHV | Crystal structure of VPS4 and VTA1 | x-ray diffraction | C | — | — |
| 4NIQ | Crystal Structure of Vps4 MIT-Vfa1 MIM2 | x-ray diffraction | A, B | — | — |
| 4NIQ | Crystal structure of VPS4 mit-VFA1 MIM2 | x-ray diffraction | A, B | — | — |
| 5FVK | Crystal structure of Vps4-Vfa1 complex from S.cerevisiae at 1.66 A resolution. | x-ray diffraction | A, B | — | — |
| 5FVK | Crystal structure of VPS4-VFA1 complex from S.CEREVISIAE at 1.66 a resolution. | x-ray diffraction | A, B | — | — |
| 5FVL | Crystal structure of VPS4-VPS20 complex from S.CEREVISIAE | x-ray diffraction | A, B | — | — |
| 5UIE | VPS4-VTA1 complex | electron microscopy | A, B, C, D, E, F | ACE, ADP, BEF, MG | — |
| 5XMI | Cryo-EM structure of the ATP-bound VPS4 mutant-E233Q hexamer (masked) | electron microscopy | A, B, C, D, E, F | ATP | — |
| 5XMK | Cryo-EM structure of the ATP-bound VPS4 mutant-E233Q complex with VTA1 (masked) | electron microscopy | A, B, C, D, E, F | ATP | — |
| 6AP1 | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | electron microscopy | A, B, C, D, E, F | ADP, BEF, MG | 20 (best 0.81) |
| 6AP1 | VPS4P-VTA1P complex with peptide binding to the central pore of VPS4P | electron microscopy | A, B, C, D, E, F | ACE, ADP, BEF, MG | — |
| 6BMF | Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p | electron microscopy | A, B, C, D, E | ADP, BEF, MG | — |
| 6BMF | VPS4P-VTA1P complex with peptide binding to the central pore of VPS4P | electron microscopy | A, B, C, D, E | ACE, ADP, BEF, MG | — |
| 6NDY | Vps4 with Cyclic Peptide Bound in the Central Pore | electron microscopy | A, B, C, D, E | ADP, BEF, MG | 20 (best 0.79) |
| 6NDY | VPS4 with cyclic peptide bound in the central pore | electron microscopy | A, B, C, D, E | ADP, BEF, MG | — |
| 6OO2 | VPS4 with cyclic peptide bound in the central pore | electron microscopy | A, B, C, D, E, F | ADP, BEF, MG | — |
| P52917 | AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 4 (P52917) | — | — | — |
Ligands
Experiment against prediction
- 6AP1 chain F against the predicted model Q9I747: TM-score 0.18, RMSD 5.50 Å
- 6AP1 chain F against the predicted model Q9I747: TM-score 0.18, RMSD 5.50 Å
- 6AP1 chain D against the predicted model Q9I747: TM-score 0.17, RMSD 5.66 Å
- 6AP1 chain B against the predicted model Q9I747: TM-score 0.17, RMSD 5.69 Å
- 6AP1 chain B against the predicted model Q9I747: TM-score 0.17, RMSD 5.69 Å
- 6AP1 chain C against the predicted model Q9I747: TM-score 0.17, RMSD 5.66 Å
- 6AP1 chain E against the predicted model Q9I747: TM-score 0.17, RMSD 5.40 Å
- 6AP1 chain E against the predicted model Q9I747: TM-score 0.17, RMSD 5.40 Å
- 6AP1 chain A against the predicted model Q9I747: TM-score 0.17, RMSD 5.47 Å
- 6AP1 chain A against the predicted model Q9I747: TM-score 0.17, RMSD 5.47 Å
Elsewhere
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