UniProt P49802
Isoform 2 of Regulator of G-protein signaling 7 (P49802)
Isoform 2 of Regulator of G-protein signaling 7 (UniProt P49802): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P49802
- Protein
- Isoform 2 of Regulator of G-protein signaling 7
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 19 · 2 records with a druggable one
Structures
11 records of P49802 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2A72 | Structure of the regulator of G-protein signaling domain of RGS7 | x-ray diffraction | A, B | — | — |
| 2A72 | Structure of the regulator of G-protein signaling domain of RGS7 | x-ray diffraction | A, B | — | — |
| 2D9J | Solution structure of the RGS domain of Regulator of G-protein signaling 7 | solution nmr | A | — | — |
| 2D9J | Solution structure of the rgs domain of regulator of G-protein signaling 7 | solution nmr | A | — | — |
| 7EWP | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio | electron microscopy | C | — | — |
| 7EWP | Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:1:1 ratio | electron microscopy | C | — | — |
| 7EWR | Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio | electron microscopy | E, C | — | — |
| 7EWR | Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:2:2 ratio | electron microscopy | E, C | — | — |
| 7SHF | Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex | electron microscopy | C | CLR | 13 (best 0.86) |
| 7SHF | Cryo-EM structure of GPR158 coupled to the RGS7-GBETA5 complex | electron microscopy | C | — | — |
| P49802 | AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 7 (P49802) | predicted | A | — | 6 (best 0.59) |
Ligands
- CLR · Cholesterol · in 1 record
Experiment against prediction
- 7EWR chain E against the predicted model P49802: TM-score 0.97, RMSD 1.46 Å
- 7EWR chain E against the predicted model P49802: TM-score 0.97, RMSD 1.46 Å
- 7SHF chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 7SHF chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 7EWP chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 7EWP chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 7EWR chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 7EWR chain C against the predicted model P49802: TM-score 0.96, RMSD 1.76 Å
- 2D9J chain A against the predicted model P49802: TM-score 0.89, RMSD 1.79 Å
- 2D9J chain A against the predicted model P49802: TM-score 0.89, RMSD 1.79 Å
Elsewhere
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