MolNFT v1 · #341758 · protein
AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 7 (P49802)
P49802: “AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 7 (P49802)”. 6 pockets (best druggability 0.59). MolNFT v1 #341758 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P49802
- Type
- protein
- Length
- 495 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6Ed09D80e98fE15DE51C9E7a8896AbF1f2365C3e
- Molecule
- Regulator of G-protein signaling 7
- UniProt
- P49802
- Pockets
- 6 · best druggability 0.59
Structure
1 distinct chain · 52% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of G-protein signaling 7 | protein | 495 | 52% helix, 4% strand | P49802 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 408 | 0.59 | 0.76 | 38 | empty |
| 2 | 161 | 0.57 | 0.81 | 24 | empty |
| 3 | 142 | 0.53 | 0.81 | 24 | empty |
| 4 | 117 | 0.44 | 0.77 | 20 | empty |
| 5 | 112 | 0.43 | 0.77 | 15 | empty |
Compared structures
- 7SHF · Cryo-EM structure of GPR158 coupled to the RGS7-GBETA5 complex · an experimental structure of the same protein · chain A against C, TM-score 0.78
- 7SHF · Cryo-EM structure of GPR158 coupled to the RGS7-Gbeta5 complex · an experimental structure of the same protein · chain A against C, TM-score 0.78
- 7EWP · Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:1:1 ratio · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 7EWP · Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:1:1 ratio · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 7EWR · Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 7EWR · Cryo-EM structure of human GPR158 in complex with RGS7-GBETA5 in a 2:2:2 ratio · an experimental structure of the same protein · chain A against C, TM-score 0.77
- 2D9J · Solution structure of the rgs domain of regulator of G-protein signaling 7 · an experimental structure of the same protein · chain A against A, TM-score 0.26
- 2D9J · Solution structure of the RGS domain of Regulator of G-protein signaling 7 · an experimental structure of the same protein · chain A against A, TM-score 0.26
- 2A72 · Structure of the regulator of G-protein signaling domain of RGS7 · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 2A72 · Structure of the regulator of G-protein signaling domain of RGS7 · an experimental structure of the same protein · chain A against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49802
- Elsewhere: UniProt P49802 · AlphaFold DB P49802
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