UniProt P48546
Gastric inhibitory polypeptide receptor (P48546)
Gastric inhibitory polypeptide receptor (UniProt P48546): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P48546
- Protein
- Gastric inhibitory polypeptide receptor
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 2 records with a druggable one
Structures
14 records of P48546 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QKH | Crystal structure of the extracellular domain of human GIP receptor in complex with the hormone GIP | x-ray diffraction | A | — | — |
| 2QKH | Crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip | x-ray diffraction | A | — | — |
| 4HJ0 | Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution | x-ray diffraction | A, B | — | — |
| 4HJ0 | Crystal structure of the human gipr ecd in complex with GIPG013 Fab at 3-a resolution | x-ray diffraction | A, B | — | — |
| 6DKJ | Human gipr ecd and Fab complex | x-ray diffraction | C, D | — | — |
| 7FIN | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human gipr-gs complex | electron microscopy | R | CLR | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex | electron microscopy | R | CLR | — |
| 7FIY | Cryo-EM structure of the tirzepatide-bound human gipr-gs complex | electron microscopy | R | CLR | — |
| 7RA3 | Cryo-EM of human gastric inhibitory polypeptide receptor gipr bound to gip | electron microscopy | R | — | — |
| 7RBT | cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | electron microscopy | R | 41Y | 6 (best 0.74) |
| 7RBT | Cryo-EM structure of human gastric inhibitory polypeptide receptor gipr bound to tirzepatide | electron microscopy | R | 41Y | — |
| 7VAB | Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human gipr-gs complex | electron microscopy | R | CLR | — |
| 8ITM | Cryo-EM structure of GIPR splice variant 2 (SV2) in complex with Gs protein | electron microscopy | R | — | 5 (best 0.72) |
| P48546 | AlphaFold monomer V2.0 prediction for gastric inhibitory polypeptide receptor (P48546) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4HJ0 chain A against the predicted model P48546: TM-score 0.96, RMSD 0.80 Å
- 4HJ0 chain A against the predicted model P48546: TM-score 0.96, RMSD 0.80 Å
- 2QKH chain A against the predicted model P48546: TM-score 0.94, RMSD 1.15 Å
- 2QKH chain A against the predicted model P48546: TM-score 0.94, RMSD 1.15 Å
- 6DKJ chain C against the predicted model P48546: TM-score 0.93, RMSD 1.49 Å
- 4HJ0 chain B against the predicted model P48546: TM-score 0.91, RMSD 1.21 Å
- 4HJ0 chain B against the predicted model P48546: TM-score 0.91, RMSD 1.21 Å
- 7VAB chain R against the predicted model P48546: TM-score 0.91, RMSD 1.27 Å
- 6DKJ chain D against the predicted model P48546: TM-score 0.90, RMSD 1.97 Å
- 8ITM chain R against the predicted model P48546: TM-score 0.87, RMSD 2.49 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.