UniProt P47811
Mitogen-activated protein kinase 14 (P47811)
Mitogen-activated protein kinase 14 (UniProt P47811), EC 2.7.11.24: 198 experimental structures and 1 predicted model on GenesisL1, 92 ligands bound, 111 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P47811
- Protein
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- Experimental structures
- 198
- Predicted models
- 1
- Ligands
- 92
- Pockets
- 111 · 20 records with a druggable one
Structures
199 records of P47811 in the MolNFT archive: 198 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LEW | Crystal structure of MAP kinase P38 complexed to the docking site on its nuclear substrate MEF2A | x-ray diffraction | A | — | — |
| 1LEW | Crystal structure of MAP kinase P38 complexed to the docking site on its nuclear substrate MEF2A | x-ray diffraction | A | — | — |
| 1LEZ | Crystal structure of MAP kinase P38 complexed to the docking site on its activator MKK3B | x-ray diffraction | A | — | — |
| 1LEZ | Crystal structure of MAP kinase P38 complexed to the docking site on its activator MKK3B | x-ray diffraction | A | — | — |
| 1YW2 | Mutated Mus Musculus P38 Kinase (mP38) | x-ray diffraction | A | — | — |
| 1YW2 | Mutated mus musculus P38 kinase (MP38) | x-ray diffraction | A | — | — |
| 1YWR | Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone… | x-ray diffraction | A | — | — |
| 1YWR | Crystal structure analysis of inactive P38 kinase domain in complex with a monocyclic pyrazolone… | x-ray diffraction | A | — | — |
| 2EWA | Dual binding mode of pyridinylimidazole to MAP kinase p38 | x-ray diffraction | A | — | — |
| 2EWA | Dual binding mode of pyridinylimidazole to MAP kinase P38 | x-ray diffraction | A | — | — |
| 2GHL | Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743 | x-ray diffraction | A | — | — |
| 2GHL | Mutant mus musculus P38 kinase domain in complex with inhibitor pg- 874743 | x-ray diffraction | A | — | — |
| 2GHM | Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449 | x-ray diffraction | A | — | — |
| 2GHM | Mutated MAP kinase P38 (mus musculus) in complex with inhbitor pg- 895449 | x-ray diffraction | A | — | — |
| 2GTM | Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579 | x-ray diffraction | A | — | — |
| 2GTM | Mutated mouse P38 MAP kinase domain in complex with inhibitor pg- 892579 | x-ray diffraction | A | — | — |
| 2GTN | Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717 | x-ray diffraction | A | — | — |
| 2GTN | Mutated MAP kinase P38 (mus musculus) in complex with inhbitor pg- 951717 | x-ray diffraction | A | — | — |
| 2OZA | Structure of p38alpha complex | x-ray diffraction | B | — | — |
| 2OZA | Structure of P38ALPHA complex | x-ray diffraction | B | — | — |
| 2PUU | Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4… | x-ray diffraction | A | — | — |
| 2PUU | Crystal structure of P38 complex with 1-(5-tert-butyl-2-P-tolyl-2H… | x-ray diffraction | A | — | — |
| 3P4K | The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution | x-ray diffraction | A | — | — |
| 3P4K | The third conformation of P38A MAP kinase observed in phosphorylated P38A and in solution | x-ray diffraction | A | — | — |
| 3P5K | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P5K | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P78 | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P78 | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P79 | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P79 | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7A | p38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7A | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7B | p38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7B | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7C | p38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3P7C | P38 inhibitor-bound | x-ray diffraction | A | — | — |
| 3PY3 | Crystal structure of phosphorylated p38alpha MAP kinase | x-ray diffraction | A | — | — |
| 3PY3 | Crystal structure of phosphorylated P38ALPHA MAP kinase | x-ray diffraction | A | — | — |
| 3TG1 | Crystal structure of p38alpha in complex with a MAPK docking partner | x-ray diffraction | A | — | — |
| 3TG1 | Crystal structure of P38ALPHA in complex with a MAPK docking partner | x-ray diffraction | A | — | — |
| 4KA3 | Structure of MAP kinase in complex with a docking peptide | x-ray diffraction | A | — | — |
| 4KA3 | Structure of MAP kinase in complex with a docking peptide | x-ray diffraction | A | — | — |
| 4LOO | Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form) | x-ray diffraction | A | — | — |
| 4LOO | Structural basis of autoactivation of P38 alpha induced by TAB1 (monoclinic crystal form) | x-ray diffraction | A | — | — |
| 4LOP | Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) | x-ray diffraction | A, B, C, D | — | — |
| 4LOP | Structural basis of autoactivation of P38 alpha induced by TAB1 (tetragonal crystal form) | x-ray diffraction | A, B, C, D | — | — |
| 4LOQ | Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound… | x-ray diffraction | A, B, C, D | — | — |
| 4LOQ | Structural basis of autoactivation of P38 alpha induced by TAB1 (tetragonal crystal form with bound… | x-ray diffraction | A, B, C, D | — | — |
| 4TYH | Ternary complex of P38 and MK2 with a P38 inhibitor | x-ray diffraction | B | — | — |
| 4TYH | Ternary complex of P38 and MK2 with a P38 inhibitor | x-ray diffraction | B | — | — |
| 5LAR | Crystal structure of p38 alpha MAPK14 in complex with VPC00628 | x-ray diffraction | A | 6SH | — |
| 5LAR | Crystal structure of P38 alpha MAPK14 in complex with VPC00628 | x-ray diffraction | A | 6SH | — |
| 5NZZ | Crystal structure of phosphorylated p38aMAPK in complex with TAB1 | x-ray diffraction | E, F, G, H | AGS, MG, NI | — |
| 5NZZ | Crystal structure of phosphorylated P38AMAPK in complex with TAB1 | x-ray diffraction | E, F, G, H | AGS, MG, NI | — |
| 5O90 | Crystal structure of a P38ALPHA T185G mutant in complex with TAB1 peptide. | x-ray diffraction | A | SB4 | — |
| 5R8U | Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment N05703B in complex with MAP… | x-ray diffraction | A | SLS, CL, SO4, MG | — |
| 5R8V | Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment N09139B in complex with MAP… | x-ray diffraction | A | SLV, CL, MG, SO4 | — |
| 5R8W | Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment K00283C in complex with MAP… | x-ray diffraction | A | JND, CL, MG, SO4 | — |
| 5R8X | PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment N11396a in complex with MAP… | x-ray diffraction | A | SLY, CL, MG, SO4 | 6 (best 0.70) |
| 5R8X | Pandda analysis group deposition FORM1 MAP kinase P38-alpha -- fragment N11396A in complex with MAP… | x-ray diffraction | A | SLY, CL, MG, SO4 | — |
139 records more on the page itself.
Ligands
- CL · Chloride ion · in 80 records
- SO4 · Sulfate ion · in 73 records
- MG · Magnesium ion · in 66 records
- SB4 · 4-(4-fluorophenyl)-1-(4-piperidinyl)-5-(2-amino-4-pyrimidinyl)-imidazole · in 18 records
- CA · Calcium ion · in 17 records
- LOT · 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide · in 3 records
- LOW · (5~{S},7~{R})-3-azanyladamantan-1-ol · in 3 records
- 308 · (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine · in 2 records
- 6SH · 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- 6T5 · 6-methyl-5-[(4-propan-2-ylphenyl)amino]-2~{H}-1,2,4-triazin-3-one · in 2 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 2 records
- JFS · [4-(1H-benzimidazol-1-yl)phenyl]methanol · in 2 records
- JGG · N-[(4-cyanophenyl)methyl]morpholine-4-carboxamide · in 2 records
- LO8 · (2~{S})-2-methyl-4-(oxetan-3-yl)-~{N}-(phenylmethyl) piperazine-2-carboxamide · in 2 records
- LOE · 1-[[(3~{S})-1,4-dioxaspiro[4.5]decan-3-yl]methyl]piperidine · in 2 records
- NI · Nickel (II) ion · in 2 records
- O8Q · 5-azanyl-~{N}-[[4-[[(2~{S})-1-[2-(4-chlorophenyl) ethylamino]-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- O8W · 5-azanyl-~{N}-[[4-[[(2~{S})-1-[[(2~{S})-butan-2-yl]amino]-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- O8Z · 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- OEB · 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-oxidanylidene-1-(pyridin-4-ylmethylamino)butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- OFQ · (2-azanyl-2-adamantyl)methanol · in 2 records
- OFW · (2~{R})-~{N}-[(2-azanyl-2-adamantyl)methyl]-4-[6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridin-3-yl]sulfonyl-2-methyl-morpholine-2-carboxamide · in 2 records
- OU2 · 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-(ethylamino)-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide · in 2 records
- SB2 · 4-[5-(4-fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-3H-imidazol-4-yl]-pyridine · in 2 records
- SLY · (2-phenoxyphenyl)methanamine · in 2 records
- SO7 · (3~{S})-~{N}-methoxy-1-(4-methoxyphenyl)-~{N}-methyl-5-oxidanylidene-pyrrolidine-3-carboxamide · in 2 records
- SOV · 5-[2,5-bis(oxidanylidene)pyrrol-1-yl]-2-methyl-benzenecarbonitrile · in 2 records
- SQG · 2-cyano-~{N}-[4-(trifluoromethyloxy)phenyl]ethanamide · in 2 records
- STV · ~{N}-(1,3-benzodioxol-5-ylmethyl)ethanesulfonamide · in 2 records
- SU7 · 3-oxidanylidene-3-[4-(phenylmethyl)piperidin-1-yl]propanenitrile · in 2 records
Experiment against prediction
- 2GHL chain A against the predicted model P47811: TM-score 0.99, RMSD 0.80 Å
- 2GHL chain A against the predicted model P47811: TM-score 0.99, RMSD 0.80 Å
- 2EWA chain A against the predicted model P47811: TM-score 0.99, RMSD 0.93 Å
- 2EWA chain A against the predicted model P47811: TM-score 0.99, RMSD 0.93 Å
- 2GHM chain A against the predicted model P47811: TM-score 0.99, RMSD 0.91 Å
- 2GHM chain A against the predicted model P47811: TM-score 0.99, RMSD 0.91 Å
- 1YWR chain A against the predicted model P47811: TM-score 0.98, RMSD 1.11 Å
- 1YWR chain A against the predicted model P47811: TM-score 0.98, RMSD 1.11 Å
- 4TYH chain B against the predicted model P47811: TM-score 0.98, RMSD 1.00 Å
- 7Z6I chain AAA against the predicted model P47811: TM-score 0.98, RMSD 1.11 Å
Elsewhere
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