UniProt P45844
Isoform 4 of ATP-binding cassette sub-family G member 1 (P45844)
Isoform 4 of ATP-binding cassette sub-family G member 1 (UniProt P45844), EC 7.6.2.-: 6 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 14 pockets. Binding sites, druggability and experiment against…
- UniProt
- P45844
- Protein
- Isoform 4 of ATP-binding cassette sub-family G member 1
- EC
- 7.6.2.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 14 · 1 record with a druggable one
Structures
7 records of P45844 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7FDV | Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol | electron microscopy | A, D | ATP, HWP, CLR | — |
| 7OZ1 | Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | electron microscopy | A, B | ATP, Y01, PEE | — |
| 7R8C | The structure of human ABCG1 | electron microscopy | A, B | — | — |
| 7R8D | The structure of human ABCG1 E242Q with cholesterol | electron microscopy | A, B | CLR | 14 (best 0.78) |
| 7R8D | The structure of human ABCG1 E242Q with cholesterol | electron microscopy | A, B | CLR | — |
| 7R8E | The structure of human ABCG1 E242Q complexed with ATP | electron microscopy | A, B | ATP, MG, CLR | — |
| P45844 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family G member 1 (P45844) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 4 records
- ATP · Adenosine-5'-triphosphate · in 3 records
- HWP · [(E,2S,3R)-2-(hexadecanoylamino)-3-oxidanyl-octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate · in 1 record
- MG · Magnesium ion · in 1 record
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 7R8C chain B against the predicted model P45844: TM-score 0.98, RMSD 1.15 Å
- 7R8C chain A against the predicted model P45844: TM-score 0.98, RMSD 1.15 Å
- 7R8D chain B against the predicted model P45844: TM-score 0.98, RMSD 1.24 Å
- 7R8D chain B against the predicted model P45844: TM-score 0.98, RMSD 1.24 Å
- 7R8D chain A against the predicted model P45844: TM-score 0.98, RMSD 1.24 Å
- 7R8D chain A against the predicted model P45844: TM-score 0.98, RMSD 1.24 Å
- 7OZ1 chain A against the predicted model P45844: TM-score 0.97, RMSD 1.45 Å
- 7OZ1 chain B against the predicted model P45844: TM-score 0.97, RMSD 1.45 Å
- 7FDV chain D against the predicted model P45844: TM-score 0.96, RMSD 1.65 Å
- 7FDV chain A against the predicted model P45844: TM-score 0.96, RMSD 1.65 Å
Elsewhere
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