MolNFT v1 · #186272 · protein
The structure of human ABCG1 E242Q with cholesterol
7R8D · Isoform 4 of ATP-binding cassette sub-family G member 1: “The structure of human ABCG1 E242Q with cholesterol”. Electron microscopy, 1 ligand (CLR), 14 pockets (best druggability 0.78). MolNFT v1 #186272 on GenesisL1: 3D structure…
- PDB
- 7R8D
- Type
- protein
- Length
- 1,090 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 4 of ATP-binding cassette sub-family G member 1
- EC
- 7.6.2.-
- UniProt
- P45844
- Ligands
- CLR
- Pockets
- 14 · best druggability 0.78
Structure
electron microscopy · 1 distinct chain · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Isoform 4 of ATP-binding cassette sub-family G member 1 (EC 7.6.2.-) | protein | 545 | 54% helix, 10% strand | P45844 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1024 | 0.78 | 0.79 | 68 | CLR |
| 2 | 101 | 0.76 | 0.97 | 27 | empty |
| 3 | 416 | 0.73 | 0.83 | 56 | empty |
| 4 | 134 | 0.46 | 0.77 | 19 | empty |
| 5 | 124 | 0.42 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2344 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 7R8D · The structure of human ABCG1 E242Q with cholesterol · the same entry in another collection · chain A against A, TM-score 1.00
- P45844 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family G member 1 (P45844) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45844
- Elsewhere: RCSB PDB 7R8D · PDBe 7R8D · UniProt P45844
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.