UniProt P38249
Eukaryotic translation initiation factor 3 subunit A (P38249)
Eukaryotic translation initiation factor 3 subunit A (UniProt P38249): 13 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P38249
- Protein
- Eukaryotic translation initiation factor 3 subunit A
- Experimental structures
- 13
- Predicted models
- 1
- Pockets
- 2 · 2 records with a druggable one
Structures
14 records of P38249 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | o | — | — |
| 3JAP | Structure of a partial yeast 48S preinitiation complex in closed conformation | electron microscopy | o | — | — |
| 4K51 | Crystal Structure of the PCI domain of eIF3a | x-ray diffraction | A, B | — | — |
| 4K51 | Crystal structure of the pci domain of EIF3A | x-ray diffraction | A, B | — | — |
| 4U1C | Crystal structure of the eIF3a/eIF3c PCI-domain heterodimer | x-ray diffraction | A | — | — |
| 4U1C | Crystal structure of the EIF3A/EIF3C pci-domain heterodimer | x-ray diffraction | A | — | — |
| 4U1D | Structure of the PCI domain of translation initiation factor eIF3a | x-ray diffraction | C, B, A | — | — |
| 4U1D | Structure of the pci domain of translation initiation factor EIF3A | x-ray diffraction | C, B, A | — | — |
| 6GSM | Structure of a partial yeast 48S preinitiation complex in open conformation. | electron microscopy | o | — | — |
| 6ZCE | Structure of a yeast ABCE1-bound 43S pre-initiation complex | electron microscopy | o | — | — |
| 6ZU9 | Structure of a yeast ABCE1-bound 48S initiation complex | electron microscopy | o | — | 1 (best 0.80) |
| 6ZU9 | Structure of a yeast ABCE1-bound 48S initiation complex | electron microscopy | o | — | — |
| 8CAS | Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial) | electron microscopy | o | — | 1 (best 0.80) |
| P38249 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit a (P38249) | predicted | A | — | — |
Experiment against prediction
- 4U1D chain B against the predicted model P38249: TM-score 0.99, RMSD 0.77 Å
- 4U1D chain B against the predicted model P38249: TM-score 0.99, RMSD 0.77 Å
- 4U1D chain C against the predicted model P38249: TM-score 0.99, RMSD 0.95 Å
- 4U1D chain C against the predicted model P38249: TM-score 0.99, RMSD 0.95 Å
- 4U1D chain A against the predicted model P38249: TM-score 0.98, RMSD 1.16 Å
- 4U1D chain A against the predicted model P38249: TM-score 0.98, RMSD 1.16 Å
- 4K51 chain B against the predicted model P38249: TM-score 0.96, RMSD 0.93 Å
- 4K51 chain B against the predicted model P38249: TM-score 0.96, RMSD 0.93 Å
- 4U1C chain A against the predicted model P38249: TM-score 0.96, RMSD 1.54 Å
- 4U1C chain A against the predicted model P38249: TM-score 0.96, RMSD 1.54 Å
Elsewhere
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