MolNFT v1 · #107154 · protein
Structure of the pci domain of translation initiation factor EIF3A
4U1D · Eukaryotic translation initiation factor 3 subunit a: “Structure of the pci domain of translation initiation factor EIF3A”. X-ray diffraction, 10 pockets (best druggability 0.82). MolNFT v1 #107154 on GenesisL1: 3D structure…
- PDB
- 4U1D
- Type
- protein
- Length
- 1,352 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit a
- UniProt
- P38249
- Pockets
- 10 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Eukaryotic translation initiation factor 3 subunit a | protein | 444 | 71% helix, 2% strand | P38249 |
| B | Eukaryotic translation initiation factor 3 subunit a | protein | 449 | 72% helix, 2% strand | P38249 |
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 459 | 73% helix, 2% strand | P38249 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 863 | 0.82 | 0.84 | 103 | empty |
| 2 | 685 | 0.80 | 0.85 | 75 | empty |
| 3 | 977 | 0.75 | 0.78 | 82 | empty |
| 4 | 304 | 0.75 | 0.87 | 45 | empty |
| 5 | 720 | 0.73 | 0.79 | 79 | empty |
Interfaces
3 interfaces between chains.
- C–B · 1493 Ų buried · 13 hydrogen bonds · protein-protein
- B–A · 969 Ų buried · 8 hydrogen bonds · protein-protein
- C–A · 768 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 4U1D · Structure of the PCI domain of translation initiation factor eIF3a · the same entry in another collection · chain C against C, TM-score 1.00
- P38249 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38249
- Elsewhere: RCSB PDB 4U1D · PDBe 4U1D · UniProt P38249
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