MolNFT v1 · #107153 · protein
Crystal structure of the EIF3A/EIF3C pci-domain heterodimer
4U1C · Eukaryotic translation initiation factor 3 subunit C: “Crystal structure of the EIF3A/EIF3C pci-domain heterodimer”. X-ray diffraction, 12 pockets (best druggability 0.73). MolNFT v1 #107153 on GenesisL1: 3D structure, binding sites…
- PDB
- 4U1C
- Type
- protein
- Length
- 815 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit C; Eukaryotic translation initiation…
- UniProt
- P32497, P38249
- Pockets
- 12 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Eukaryotic translation initiation factor 3 subunit C | protein | 544 | 68% helix, 2% strand | P32497 |
| A | Eukaryotic translation initiation factor 3 subunit a | protein | 271 | 70% helix, 4% strand | P38249 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 510 | 0.73 | 0.82 | 57 | empty |
| 2 | 951 | 0.70 | 0.75 | 69 | empty |
| 3 | 363 | 0.69 | 0.82 | 44 | empty |
| 4 | 92 | 0.47 | 0.80 | 23 | empty |
| 5 | 125 | 0.45 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- C–A · 1258 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 4U1C · Crystal structure of the eIF3a/eIF3c PCI-domain heterodimer · the same entry in another collection · chain C against C, TM-score 1.00
- P38249 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain A against A, TM-score 0.96
- P32497 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32497
- Every structure of UniProt P38249
- Elsewhere: RCSB PDB 4U1C · PDBe 4U1C · UniProt P32497 · UniProt P38249
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