UniProt P37595
Putative L-asparaginase (P37595)
Putative L-asparaginase (UniProt P37595), EC 3.4.19.5, 3.5.1.1: 26 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 130 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P37595
- Protein
- Putative L-asparaginase
- EC
- 3.4.19.5, 3.5.1.1
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 130 · 24 records with a druggable one
Structures
27 records of P37595 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JN9 | Structure of Putative Asparaginase Encoded by Escherichia coli ybiK Gene | x-ray diffraction | A, B, C, D | NA, CL, CA | 5 (best 0.61) |
| 1JN9 | Structure of putative asparaginase encoded by escherichia COLI ybik gene | x-ray diffraction | A, B, C, D | NA, CL, CA | 5 (best 0.61) |
| 1K2X | Crystal structure of putative asparaginase encoded by Escherichia coli ybiK gene | x-ray diffraction | A, B, C, D | NA, CL | 6 (best 0.55) |
| 1K2X | Crystal structure of putative asparaginase encoded by escherichia COLI ybik gene | x-ray diffraction | A, B, C, D | NA, CL | 6 (best 0.55) |
| 1T3M | Structure of the isoaspartyl peptidase with L-asparaginase activity from E. coli | x-ray diffraction | A, B, C, D | NA, NO3 | 5 (best 0.60) |
| 1T3M | Structure of the isoaspartyl peptidase with L-asparaginase activity from E. COLI | x-ray diffraction | A, B, C, D | NA, NO3 | 5 (best 0.60) |
| 2ZAK | Orthorhombic crystal structure of precursor E. coli isoaspartyl peptidase/L-asparaginase (EcAIII)… | x-ray diffraction | A, B | NA, CL | 4 (best 0.58) |
| 2ZAK | Orthorhombic crystal structure of precursor E. COLI isoaspartyl PEPTIDASE/L-asparaginase (ecaiii)… | x-ray diffraction | A, B | NA, CL | 4 (best 0.58) |
| 2ZAL | Crystal structure of E. coli isoaspartyl aminopeptidase/L-asparaginase in complex with L-aspartate | x-ray diffraction | A, B, C, D | NA, CA, ASP, CL | 5 (best 0.58) |
| 2ZAL | Crystal structure of E. COLI isoaspartyl AMINOPEPTIDASE/L-asparaginase in complex with L-aspartate | x-ray diffraction | A, B, C, D | NA, CA, ASP, CL | 5 (best 0.58) |
| 3C17 | Hexagonal Crystal Structure of Precursor E. coli Isoaspartyl Peptidase/l-Asparaginase (ECAIII) with… | x-ray diffraction | A, B | NA, CL | 3 (best 0.49) |
| 3C17 | Hexagonal crystal structure of precursor E. COLI isoaspartyl PEPTIDASE/L-asparaginase (ecaiii) with… | x-ray diffraction | A, B | NA, CL | 3 (best 0.49) |
| 7QSF | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-12 (G206C, R207T, D210A, S211A) | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CL | 5 (best 0.68) |
| 7QTC | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-3 (G206H, R207T, D210P, S211Q) | x-ray diffraction | AAA, BBB, CCC, DDD | NA | 6 (best 0.57) |
| 7QVR | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-37 (G206S, R207T, D210S) | x-ray diffraction | AAA, CCC | NA | 5 (best 0.68) |
| 7QY6 | Structure of E.coli Class 2 L-asparaginase EcAIII, wild type (WT EcAIII) | x-ray diffraction | AAA, CCC | NA, CL | 5 (best 0.60) |
| 7QYM | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-18 (R207V, D210P, S211W) | x-ray diffraction | AAA, CCC | NA, CL | 6 (best 0.58) |
| 7QYX | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-24 (R207A, D210S, S211T) | x-ray diffraction | AAA, CCC | NA, CL | 4 (best 0.63) |
| 7R1G | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-38 (R207C, D210S, S211V) | x-ray diffraction | AAA, CCC | NA | 4 (best 0.64) |
| 7R5C | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant RDM1-29 (G206C, R207S, D210L, S211V) | x-ray diffraction | AAA, BBB, CCC, DDD | NA | 5 (best 0.66) |
| 8BI3 | Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200W (crystal M200W#1) | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CL, CA | 5 (best 0.56) |
| 8BKF | Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200T (crystal M200T#o) | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CL, MG | 5 (best 0.59) |
| 8BP9 | Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200W (crystal M200W#2) | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CL | 5 (best 0.61) |
| 8BQO | Structure of E.coli Class 2 L-asparaginase EcAIII, mutant M200I | x-ray diffraction | AAA, BBB, CCC, DDD | NA, CL | 5 (best 0.58) |
| 8C0I | Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200L (acyl-enzyme intermediate) | x-ray diffraction | AAA, BBB, CCC, DDD | NA, MG, CL | 5 (best 0.57) |
| 8C23 | Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200T (monoclinic form M200T#m) | x-ray diffraction | AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH | NA, GLY, CL | 9 (best 0.58) |
| P37595 | AlphaFold monomer V2.0 prediction for isoaspartyl peptidase (P37595) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8C23 chain HHH against the predicted model P37595: TM-score 1.00, RMSD 0.23 Å
- 8C23 chain BBB against the predicted model P37595: TM-score 1.00, RMSD 0.24 Å
- 3C17 chain A against the predicted model P37595: TM-score 1.00, RMSD 0.39 Å
- 3C17 chain A against the predicted model P37595: TM-score 1.00, RMSD 0.39 Å
- 3C17 chain B against the predicted model P37595: TM-score 1.00, RMSD 0.39 Å
- 3C17 chain B against the predicted model P37595: TM-score 1.00, RMSD 0.39 Å
- 1JN9 chain D against the predicted model P37595: TM-score 1.00, RMSD 0.26 Å
- 1JN9 chain D against the predicted model P37595: TM-score 1.00, RMSD 0.26 Å
- 2ZAL chain D against the predicted model P37595: TM-score 1.00, RMSD 0.29 Å
- 2ZAL chain D against the predicted model P37595: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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