UniProt P36888
Receptor-type tyrosine-protein kinase FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (UniProt P36888), EC 2.7.1.112, 2.7.10.1: 18 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 144 pockets. Binding sites, druggability and experiment against…
- UniProt
- P36888
- Protein
- Receptor-type tyrosine-protein kinase FLT3
- EC
- 2.7.1.112, 2.7.10.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 144 · 18 records with a druggable one
Structures
19 records of P36888 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RJB | Crystal Structure of FLT3 | x-ray diffraction | A | — | 4 (best 0.53) |
| 1RJB | Crystal structure of FLT3 | x-ray diffraction | A | — | 4 (best 0.53) |
| 3QS7 | Crystal structure of a human Flt3 ligand-receptor ternary complex | x-ray diffraction | E, F, G, H | NAG | 16 (best 0.65) |
| 3QS7 | Crystal structure of a human FLT3 ligand-receptor ternary complex | x-ray diffraction | E, F, G, H | NAG | 16 (best 0.65) |
| 3QS9 | Crystal structure of a human Flt3 ligand-receptor ternary complex | x-ray diffraction | E, F, G, H | — | 17 (best 0.60) |
| 3QS9 | Crystal structure of a human FLT3 ligand-receptor ternary complex | x-ray diffraction | E, F, G, H | — | 17 (best 0.60) |
| 4RT7 | Crystal Structure of FLT3 with a small molecule inhibitor | x-ray diffraction | A | P30 | 1 (best 0.73) |
| 4RT7 | Crystal structure of FLT3 with a small molecule inhibitor | x-ray diffraction | A | P30 | 1 (best 0.73) |
| 4XUF | Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220) | x-ray diffraction | A, B | P30 | 4 (best 0.73) |
| 4XUF | Crystal structure of the FLT3 kinase domain bound to the inhibitor quizartinib (AC220) | x-ray diffraction | A, B | P30 | 4 (best 0.73) |
| 5X02 | Crystal structure of the FLT3 kinase domain bound to the inhibitor FF-10101 | x-ray diffraction | A | F6M, SO4 | 4 (best 0.68) |
| 5X02 | Crystal structure of the FLT3 kinase domain bound to the inhibitor ff- 10101 | x-ray diffraction | A | F6M, SO4 | 4 (best 0.68) |
| 6IL3 | Crystal structure of the FLT3 kinase bound to a small molecule inhibitor | x-ray diffraction | A | A9R, PO4, CL | 4 (best 0.68) |
| 6IL3 | Crystal structure of the FLT3 kinase bound to a small molecule inhibitor | x-ray diffraction | A | A9R, PO4, CL | 4 (best 0.68) |
| 6JQR | Crystal structure of FLT3 in complex with gilteritinib | x-ray diffraction | A | C6F, SO4 | 3 (best 0.70) |
| 6JQR | Crystal structure of FLT3 in complex with gilteritinib | x-ray diffraction | A | C6F, SO4 | 3 (best 0.70) |
| 7QDP | Crystal structure of FLT3 T343I in complex with the canonical ligand FL | x-ray diffraction | E, F, G, H | NAG | 19 (best 0.81) |
| 7ZV9 | Crystal structure of FLT3 in complex with a monomeric FLT3 Ligand variant | x-ray diffraction | B, D, F, H, J, L, N, P | NAG | 19 (best 0.84) |
| P36888 | AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein kinase FLT3 (P36888) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- P30 · 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea · in 4 records
- SO4 · Sulfate ion · in 4 records
- A9R · 7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)-3-(pyridin-2-yl)imidazo[1,2-a]pyridine · in 2 records
- C6F · 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino) pyrazine-2-carboxamide · in 2 records
- CL · Chloride ion · in 2 records
- F6M · N-[(2S)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino) pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-N-methyl-but-2-enamide · in 2 records
- PO4 · Phosphate ion · in 2 records
Experiment against prediction
- 4RT7 chain A against the predicted model P36888: TM-score 0.99, RMSD 0.58 Å
- 4RT7 chain A against the predicted model P36888: TM-score 0.99, RMSD 0.58 Å
- 6JQR chain A against the predicted model P36888: TM-score 0.99, RMSD 0.80 Å
- 6JQR chain A against the predicted model P36888: TM-score 0.99, RMSD 0.80 Å
- 1RJB chain A against the predicted model P36888: TM-score 0.98, RMSD 0.86 Å
- 1RJB chain A against the predicted model P36888: TM-score 0.98, RMSD 0.86 Å
- 4XUF chain A against the predicted model P36888: TM-score 0.98, RMSD 0.78 Å
- 4XUF chain A against the predicted model P36888: TM-score 0.98, RMSD 0.78 Å
- 4XUF chain B against the predicted model P36888: TM-score 0.98, RMSD 0.80 Å
- 4XUF chain B against the predicted model P36888: TM-score 0.98, RMSD 0.80 Å
Elsewhere
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