MolNFT v1 · #76683 · protein
Crystal structure of a human FLT3 ligand-receptor ternary complex
3QS9 · Sl cytokine: “Crystal structure of a human FLT3 ligand-receptor ternary complex”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #76683 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3QS9
- Type
- protein
- Length
- 2,064 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sl cytokine; Fl cytokine receptor
- EC
- 2.7.10.1
- UniProt
- P49771, P36888
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 9% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Sl cytokine | protein | 130 | 50% helix, 9% strand | P49771 |
| E, G, H | Fl cytokine receptor (EC 2.7.10.1) | protein | 405 | 1% helix, 54% strand | P36888 |
| F | Fl cytokine receptor (EC 2.7.10.1) | protein | 329 | 2% helix, 53% strand | P36888 |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 851 | 0.81 | 0.84 | 85 | empty |
| 2 | 451 | 0.60 | 0.75 | 38 | empty |
| 3 | 394 | 0.59 | 0.75 | 36 | empty |
| 4 | 380 | 0.58 | 0.75 | 37 | empty |
| 5 | 136 | 0.55 | 0.82 | 19 | empty |
Interfaces
9 interfaces between chains.
- A–B · 866 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 858 Ų buried · 15 hydrogen bonds · protein-protein
- D–G · 489 Ų buried · 4 hydrogen bonds · protein-protein
- A–E · 488 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 485 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 43 disulfide (disulfide).
Compared structures
- 3QS9 · Crystal structure of a human Flt3 ligand-receptor ternary complex · the same entry in another collection · chain H against H, TM-score 1.00
- P49771 · AlphaFold monomer V2.0 prediction for fms-related tyrosine kinase 3 ligand (P49771) · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49771
- Every structure of UniProt P36888
- Elsewhere: RCSB PDB 3QS9 · PDBe 3QS9 · UniProt P49771 · UniProt P36888
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