UniProt P36776

Lon protease homolog, mitochondrial (P36776)

Lon protease homolog, mitochondrial (UniProt P36776), EC 3.4.21.53: 47 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 465 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P36776
Protein: Lon protease homolog, mitochondrial
EC: 3.4.21.53
Experimental structures: 47
Predicted models: 1
Ligands: 8
Pockets: 465 · 26 records with a druggable one

Structures

48 records of P36776 in the MolNFT archive: 47 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2X36	Structure of the proteolytic domain of the Human Mitochondrial Lon protease	x-ray diffraction	A, B, C, D, E, F	—	—
2X36	Structure of the proteolytic domain of the human mitochondrial lon protease	x-ray diffraction	A, B, C, D, E, F	—	—
6WYS	Lon protease proteolytic domain	x-ray diffraction	A, B, C	SO4	5 (best 0.76)
6WYS	Lon protease proteolytic domain	x-ray diffraction	A, B, C	SO4	—
6WZV	Lon protease proteolytic domain	x-ray diffraction	A, B, C	UFY, SO4	5 (best 0.77)
6WZV	Lon protease proteolytic domain	x-ray diffraction	A, B, C	UFY, SO4	—
6X1M	Lon protease proteolytic domain complexed with covalent boronic acid inhibitor	x-ray diffraction	A, B, C	UKS	5 (best 0.74)
6X1M	Lon protease proteolytic domain complexed with covalent boronic acid inhibitor	x-ray diffraction	A, B, C	UKS	—
6X27	Lon protease proteolytic domain complexed with bortezomib	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L	BO2	20 (best 0.60)
6X27	Lon protease proteolytic domain complexed with bortezomib	x-ray diffraction	A, B, C, D, E, F, G, H, I, J, K, L	BO2	—
7KRZ	Human mitochondrial LONP1 in complex with Bortezomib	electron microscopy	A, B, C, D, E, F	ATP, MG, BO2, ADP	20 (best 0.85)
7KRZ	Human mitochondrial LONP1 in complex with bortezomib	electron microscopy	A, B, C, D, E, F	ATP, MG, BO2, ADP	—
7KSL	Substrate-free human mitochondrial LONP1	electron microscopy	C, B, A, F, E	ADP	20 (best 0.81)
7KSL	Substrate-free human mitochondrial LONP1	electron microscopy	C, B, A, F, E	ADP	—
7KSM	Human mitochondrial LONP1 with endogenous substrate	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.82)
7KSM	Human mitochondrial LONP1 with endogenous substrate	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7NFY	P1a-state of wild type human mitochondrial LONP1 protease with bound substrate protein and ATPgS	electron microscopy	A, B, C, D, E, F	AGS, MG, ADP	20 (best 0.89)
7NFY	P1A-state of wild type human mitochondrial LONP1 protease with bound substrate protein and atpgs	electron microscopy	A, B, C, D, E, F	AGS, MG, ADP	—
7NG4	P1b-state of wild type human mitochondrial LONP1 protease with bound endogenous substrate protein…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.85)
7NG4	P1B-state of wild type human mitochondrial LONP1 protease with bound endogenous substrate protein…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7NG5	P1c-state of wild type human mitochondrial LONP1 protease with bound substrate protein in presence…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.83)
7NG5	P1C-state of wild type human mitochondrial LONP1 protease with bound substrate protein in presence…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7NGC	P2a-state of wild type human mitochondrial LONP1 protease with bound substrate protein and in…	electron microscopy	A, B, C, D, E, F	AGS, MG, ADP	20 (best 0.87)
7NGC	P2A-state of wild type human mitochondrial LONP1 protease with bound substrate protein and in…	electron microscopy	A, B, C, D, E, F	AGS, MG, ADP	—
7NGF	P2c-state of wild type human mitochondrial LONP1 protease with bound endogenous substrate protein…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.88)
7NGF	P2C-state of wild type human mitochondrial LONP1 protease with bound endogenous substrate protein…	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7NGL	R-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.83)
7NGL	R-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP	electron microscopy	A, B, C, D, E, F	ADP	—
7NGP	D1-state of wild type human mitochondrial LONP1 protease	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.86)
7NGP	D1-state of wild type human mitochondrial LONP1 protease	electron microscopy	A, B, C, D, E, F	ADP	—
7NGQ	Human mitochondrial Lon protease homolog, D2-state	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.86)
7NGQ	Human mitochondrial lon protease homolog, D2-state	electron microscopy	A, B, C, D, E, F	ADP	—
7OXO	human LonP1, R-state, incubated in AMPPCP	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.85)
7OXO	Human LONP1, R-state, incubated in amppcp	electron microscopy	A, B, C, D, E, F	ADP	—
7P09	Human mitochondrial Lon protease with substrate in the ATPase domain	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7P09	Human mitochondrial lon protease with substrate in the ATPase domain	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
7P0B	Human mitochondrial Lon protease without substrate	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.86)
7P0B	Human mitochondrial lon protease without substrate	electron microscopy	A, B, C, D, E, F	ADP	—
7P0M	Human mitochondrial Lon protease with substrate in the ATPase and protease domains	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.84)
7P0M	Human mitochondrial lon protease with substrate in the ATPase and protease domains	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	—
8OJL	Human Mitochondrial Lon Y394E Mutant ADP Bound	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.87)
8OKA	Human Mitochondrial Lon Y394F Mutant ADP Bound	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.85)
8OM7	Human Mitochondrial Lon Y186E Mutant ADP Bound	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.83)
8OVF	Human Mitochondrial Lon Y186F Mutant ADP Bound	electron microscopy	A, B, C, D, E, F	ADP	20 (best 0.81)
8OVG	Human Mitochondrial Lon Y186E Mutant ADP Bound	electron microscopy	A, B, C, D, E, F	—	20 (best 0.84)
9CC0	Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form	electron microscopy	A, B, C, D, E, F	ATP, MG, ADP	20 (best 0.83)
9CC3	Human Mitochondrial LONP1 Stall State + casein	electron microscopy	A, B, C, D, E, F	ADP, MG	20 (best 0.86)
P36776	AlphaFold monomer V2.0 prediction for lon protease homolog, mitochondrial (P36776)	predicted	A	—	10 (best 0.63)

Ligands

ADP · Adenosine-5'-diphosphate · in 36 records
MG · Magnesium ion · in 20 records
ATP · Adenosine-5'-triphosphate · in 15 records
AGS · Phosphothiophosphoric acid-adenylate ester · in 4 records
BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · in 4 records
SO4 · Sulfate ion · in 4 records
UFY · N-[(1R)-1-borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide · in 2 records
UKS · [(1R)-4-phenyl-1-{[N-(pyrazine-2-carbonyl)-D-norvalyl]amino}butyl]boronic acid · in 2 records

Experiment against prediction

6WZV chain B against the predicted model P36776: TM-score 0.98, RMSD 0.68 Å
6WZV chain B against the predicted model P36776: TM-score 0.98, RMSD 0.68 Å
6X27 chain D against the predicted model P36776: TM-score 0.98, RMSD 0.70 Å
6X27 chain D against the predicted model P36776: TM-score 0.98, RMSD 0.70 Å
6X27 chain G against the predicted model P36776: TM-score 0.98, RMSD 0.70 Å
6X27 chain G against the predicted model P36776: TM-score 0.98, RMSD 0.70 Å
6X27 chain B against the predicted model P36776: TM-score 0.98, RMSD 0.74 Å
6X27 chain B against the predicted model P36776: TM-score 0.98, RMSD 0.74 Å
6WYS chain A against the predicted model P36776: TM-score 0.98, RMSD 0.83 Å
6WYS chain A against the predicted model P36776: TM-score 0.98, RMSD 0.83 Å

Elsewhere

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