MolNFT v1 · #180211 · protein
Substrate-free human mitochondrial LONP1
7KSL · Lon protease homolog, mitochondrial: “Substrate-free human mitochondrial LONP1”. Electron microscopy, 1 ligand (ADP), 20 pockets (best druggability 0.81). MolNFT v1 #180211 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7KSL
- Type
- protein
- Length
- 2,551 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lon protease homolog, mitochondrial
- EC
- 3.4.21.53
- UniProt
- P36776
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 42% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 489 | 44% helix, 12% strand | P36776 |
| B, A, F | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 520 | 41% helix, 14% strand | P36776 |
| E | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 502 | 40% helix, 12% strand | P36776 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 5 copies · chains C, B, A, F, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.81 | 0.86 | 76 | empty |
| 2 | 800 | 0.79 | 0.82 | 112 | ADP |
| 3 | 643 | 0.78 | 0.84 | 100 | ADP |
| 4 | 568 | 0.75 | 0.82 | 72 | empty |
| 5 | 598 | 0.74 | 0.81 | 64 | ADP |
Interfaces
4 interfaces between chains.
- B–A · 1800 Ų buried · 10 hydrogen bonds · protein-protein
- A–F · 1742 Ų buried · 9 hydrogen bonds · protein-protein
- F–E · 1625 Ų buried · 14 hydrogen bonds · protein-protein
- C–B · 1610 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7KSL · Substrate-free human mitochondrial LONP1 · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36776
- Elsewhere: RCSB PDB 7KSL · PDBe 7KSL · UniProt P36776
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