MolNFT v1 · #169147 · protein
Lon protease proteolytic domain complexed with bortezomib
6X27: “Lon protease proteolytic domain complexed with bortezomib”. X-ray diffraction, 1 ligand (BO2). MolNFT v1 #169147 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6X27
- Type
- protein
- Length
- 2,249 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P36776
- Ligands
- BO2
Structure
x-ray diffraction · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 186 | — | P36776 |
| B, F | — | protein | 185 | — | P36776 |
| C | — | protein | 194 | — | P36776 |
| D, E | — | protein | 185 | — | P36776 |
| G | — | protein | 184 | — | P36776 |
| H | — | protein | 193 | — | P36776 |
| I, J, K | — | protein | 186 | — | P36776 |
| L | — | protein | 194 | — | P36776 |
Ligands and binding sites
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · ligand · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K, L
- 1PE · Pentaethylene glycol · additive · 6 copies · chains A, G, B, K, C, L, F, J, E, H, D, I
- GOL · Glycerol · additive · 2 copies · chains G, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6X27 · Lon protease proteolytic domain complexed with bortezomib · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36776
- Elsewhere: RCSB PDB 6X27 · PDBe 6X27 · UniProt P36776
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