MolNFT v1 · #184718 · protein
Human mitochondrial lon protease without substrate
7P0B · Lon protease homolog, mitochondrial: “Human mitochondrial lon protease without substrate”. Electron microscopy, 1 ligand (ADP), 20 pockets (best druggability 0.86). MolNFT v1 #184718 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7P0B
- Type
- protein
- Length
- 3,185 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lon protease homolog, mitochondrial
- EC
- 3.4.21.53
- UniProt
- P36776
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 531 | 43% helix, 15% strand | P36776 |
| B | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 532 | 44% helix, 15% strand | P36776 |
| F | Lon protease homolog, mitochondrial (EC 3.4.21.53) | protein | 529 | 43% helix, 14% strand | P36776 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 920 | 0.86 | 0.87 | 101 | empty |
| 2 | 910 | 0.82 | 0.84 | 96 | ADP |
| 3 | 756 | 0.80 | 0.84 | 96 | ADP |
| 4 | 453 | 0.80 | 0.87 | 58 | empty |
| 5 | 331 | 0.79 | 0.89 | 51 | empty |
Interfaces
8 interfaces between chains.
- A–B · 2762 Ų buried · 34 hydrogen bonds · protein-protein
- C–D · 2645 Ų buried · 30 hydrogen bonds · protein-protein
- E–F · 2274 Ų buried · 19 hydrogen bonds · protein-protein
- D–E · 2162 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 2142 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7P0B · Human mitochondrial Lon protease without substrate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36776
- Elsewhere: RCSB PDB 7P0B · PDBe 7P0B · UniProt P36776
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