UniProt P35557
Isoform 2 of Hexokinase-4 (P35557)
Isoform 2 of Hexokinase-4 (UniProt P35557), EC 2.7.1.1, 2.7.1.2: 66 experimental structures on GenesisL1, 9 ligands bound, 28 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P35557
- Protein
- Isoform 2 of Hexokinase-4
- EC
- 2.7.1.1, 2.7.1.2
- Experimental structures
- 66
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 28 · 5 records with a druggable one
Structures
66 records of P35557 in the MolNFT archive: 66 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1V4S | Crystal structure of human glucokinase | x-ray diffraction | A | — | — |
| 1V4S | Crystal structure of human glucokinase | x-ray diffraction | A | — | — |
| 1V4T | Crystal structure of human glucokinase | x-ray diffraction | A | — | — |
| 1V4T | Crystal structure of human glucokinase | x-ray diffraction | A | — | — |
| 3A0I | Human glucokinase in complex with a synthetic activator | x-ray diffraction | X | — | — |
| 3A0I | Human glucokinase in complex with a synthetic activator | x-ray diffraction | X | — | — |
| 3F9M | Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap | x-ray diffraction | A | — | — |
| 3F9M | Human pancreatic glucokinase in complex with glucose and activator showing a mobile flap | x-ray diffraction | A | — | — |
| 3FGU | Catalytic complex of Human Glucokinase | x-ray diffraction | A | — | — |
| 3FGU | Catalytic complex of human glucokinase | x-ray diffraction | A | — | — |
| 3FR0 | Human glucokinase in complex with 2-amino benzamide activator | x-ray diffraction | A | — | — |
| 3FR0 | Human glucokinase in complex with 2-amino benzamide activator | x-ray diffraction | A | — | — |
| 3H1V | Human glucokinase in complex with a synthetic activator | x-ray diffraction | X | — | — |
| 3H1V | Human glucokinase in complex with a synthetic activator | x-ray diffraction | X | — | — |
| 3ID8 | Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-PNP | x-ray diffraction | A | — | — |
| 3ID8 | Ternary complex of human pancreatic glucokinase crystallized with activator, glucose and AMP-pnp | x-ray diffraction | A | — | — |
| 3IDH | Human pancreatic glucokinase in complex with glucose | x-ray diffraction | A | — | — |
| 3IDH | Human pancreatic glucokinase in complex with glucose | x-ray diffraction | A | — | — |
| 3QIC | The structure of human glucokinase E339K mutation | x-ray diffraction | A | — | — |
| 3QIC | The structure of human glucokinase E339K mutation | x-ray diffraction | A | — | — |
| 3S41 | Glucokinase in complex with activator and glucose | x-ray diffraction | A | — | — |
| 3S41 | Glucokinase in complex with activator and glucose | x-ray diffraction | A | — | — |
| 3VEV | Glucokinase in complex with an activator and glucose | x-ray diffraction | A | — | — |
| 3VEV | Glucokinase in complex with an activator and glucose | x-ray diffraction | A | — | — |
| 3VEY | glucokinase in complex with glucose and ATPgS | x-ray diffraction | A | — | — |
| 3VEY | Glucokinase in complex with glucose and atpgs | x-ray diffraction | A | — | — |
| 3VF6 | Glucokinase in complex with glucose and activator | x-ray diffraction | A | — | — |
| 3VF6 | Glucokinase in complex with glucose and activator | x-ray diffraction | A | — | — |
| 4DCH | Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein… | x-ray diffraction | A | — | — |
| 4DCH | Insights into glucokinase activation mechanism: observation of multiple distinct protein… | x-ray diffraction | A | — | — |
| 4DHY | Crystal structure of human glucokinase in complex with glucose and activator | x-ray diffraction | A | — | — |
| 4DHY | Crystal structure of human glucokinase in complex with glucose and activator | x-ray diffraction | A | — | — |
| 4ISE | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H… | x-ray diffraction | A | — | — |
| 4ISE | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2… | x-ray diffraction | A | — | — |
| 4ISF | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydr… | x-ray diffraction | A | — | — |
| 4ISF | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2… | x-ray diffraction | A | — | — |
| 4ISG | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiper… | x-ray diffraction | A | — | — |
| 4ISG | Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2… | x-ray diffraction | A | — | — |
| 4IWV | Crystals structure of Human Glucokinase in complex with small molecule activator | x-ray diffraction | A | — | — |
| 4IWV | Crystals structure of human glucokinase in complex with small molecule activator | x-ray diffraction | A | — | — |
| 4IXC | Crystal structure of Human Glucokinase in complex with a small molecule activator. | x-ray diffraction | A | — | — |
| 4IXC | Crystal structure of human glucokinase in complex with a small molecule activator. | x-ray diffraction | A | — | — |
| 4L3Q | Crystal structure of glucokinase-activator complex | x-ray diffraction | A | — | — |
| 4L3Q | Crystal structure of glucokinase-activator complex | x-ray diffraction | A | — | — |
| 4LC9 | Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein | x-ray diffraction | B | — | — |
| 4LC9 | Structural basis for regulation of human glucokinase by glucokinase regulatory protein | x-ray diffraction | B | — | — |
| 4MLE | Human Glucokinase in Complex with Novel Amino Thiazole Activator | x-ray diffraction | A | — | — |
| 4MLE | Human glucokinase in complex with novel amino thiazole activator | x-ray diffraction | A | — | — |
| 4MLH | Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator | x-ray diffraction | A | — | — |
| 4MLH | Human glucokinase in complex with a novel amino thiazole allosteric activator | x-ray diffraction | A | — | — |
| 4NO7 | Human Glucokinase in complex with a nanomolar activator. | x-ray diffraction | A | — | — |
| 4NO7 | Human glucokinase in complex with a nanomolar activator. | x-ray diffraction | A | — | — |
| 4RCH | Discovery of 2-Pyridyl Ureas as Glucokinase Activators | x-ray diffraction | A | — | — |
| 4RCH | Discovery of 2-pyridyl ureas as glucokinase activators | x-ray diffraction | A | — | — |
| 5V4W | Human glucokinase in complex with novel indazole activator. | x-ray diffraction | A | GLC, 8WM, IOD | 4 (best 0.64) |
| 5V4W | Human glucokinase in complex with novel indazole activator. | x-ray diffraction | A | GLC, 8WM, IOD | — |
| 5V4X | Human glucokinase in complex with novel pyrazole activator. | x-ray diffraction | A | GLC, 8WJ, IOD | 3 (best 0.66) |
| 5V4X | Human glucokinase in complex with novel pyrazole activator. | x-ray diffraction | A | GLC, 8WJ, IOD | — |
| 6E0E | Crystal structure of glucokinase in complex with compound 6 | x-ray diffraction | A | GLC, HKM | — |
| 6E0I | Crystal structure of Glucokinase in complex with compound 72 | x-ray diffraction | A | GLC, HKG | 4 (best 0.56) |
6 records more on the page itself.
Ligands
- GLC · alpha-D-glucopyranose · in 11 records
- IOD · Iodide ion · in 4 records
- 8WJ · (2S)-3-cyclohexyl-2-[4-(cyclopentylsulfonyl)-2-oxopyridin-1(2H)-yl]-N-(1,3-thiazol-2-yl)propanamide · in 2 records
- 8WM · (2S)-2-[4-(cyclopropylsulfonyl)-1H-indazol-1-yl]-N-(5-fluoro-1,3-thiazol-2-yl)-3-(oxan-4-yl)propanamide · in 2 records
- G1S · diethyl {[3-(3-{[5-(azetidine-1-carbonyl)pyrazin-2-yl]oxy}-5-[(propan-2-yl)oxy]benzamido)-1H-pyrazol-1-yl]methyl}phosphonate · in 2 records
- G2T · diethyl {[2-(3-[4-(methanesulfonyl)phenoxy]-5-{[(2S)-1-methoxypropan-2-yl]oxy}benzamido)-1,3-thiazol-4-yl]methyl}phosphonate · in 2 records
- HKG · 1-{4-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-[(pyridin-2-yl)sulfanyl]pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]piperidin-1 -yl}ethan-1-one · in 2 records
- NA · Sodium ion · in 2 records
- HKM · 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile · in 1 record
Elsewhere
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