UniProt P35439
Glutamate receptor ionotropic, NMDA 1 (P35439)
Glutamate receptor ionotropic, NMDA 1 (UniProt P35439): 124 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 207 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35439
- Protein
- Glutamate receptor ionotropic, NMDA 1
- Experimental structures
- 124
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 207 · 18 records with a druggable one
Structures
125 records of P35439 in the MolNFT archive: 124 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PB7 | Crystal structure of the NR1 ligand binding core in complex with glycine at 1.35 ångströms… | x-ray diffraction | A | — | — |
| 1PB7 | Crystal structure of the NR1 ligand binding core in complex with glycine at 1.35 ångströms… | x-ray diffraction | A | — | — |
| 1PB8 | Crystal structure of the NR1 ligand binding core in complex with D-serine at 1.45 ångströms… | x-ray diffraction | A | — | — |
| 1PB8 | Crystal structure of the NR1 ligand binding core in complex with D- serine at 1.45 ångströms… | x-ray diffraction | A | — | — |
| 1PB9 | Crystal structure of the NR1 ligand binding core in complex with D-cycloserine at 1.60 ångströms… | x-ray diffraction | A | — | — |
| 1PB9 | Crystal structure of the NR1 ligand binding core in complex with D- cycloserine at 1.60 ångströms… | x-ray diffraction | A | — | — |
| 1PBQ | Crystal structure of the NR1 ligand binding core in complex with 5,7-dichlorokynurenic acid (dcka)… | x-ray diffraction | A | — | — |
| 1PBQ | Crystal structure of the NR1 ligand binding core in complex with 5,7- dichlorokynurenic acid (dcka)… | x-ray diffraction | A | — | — |
| 1Y1M | Crystal structure of the NR1 ligand binding core in complex with cycloleucine | x-ray diffraction | A, B | — | — |
| 1Y1M | Crystal structure of the NR1 ligand binding core in complex with cycloleucine | x-ray diffraction | A, B | — | — |
| 1Y1Z | Crystal structure of the NR1 ligand binding core in complex with ACBC | x-ray diffraction | A | — | — |
| 1Y1Z | Crystal structure of the NR1 ligand binding core in complex with acbc | x-ray diffraction | A | — | — |
| 1Y20 | Crystal structure of the NR1 ligand-binding core in complex with ACPC | x-ray diffraction | A | — | — |
| 1Y20 | Crystal structure of the NR1 ligand-binding core in complex with acpc | x-ray diffraction | A | — | — |
| 2A5T | Crystal Structure Of The NR1/NR2A ligand-binding cores complex | x-ray diffraction | A | — | — |
| 2A5T | Crystal structure of the NR1/NR2A ligand-binding cores complex | x-ray diffraction | A | — | — |
| 3Q41 | Crystal structure of the GluN1 N-terminal domain (NTD) | x-ray diffraction | A, B, C | — | — |
| 3Q41 | Crystal structure of the GLUN1 N-terminal domain (ntd) | x-ray diffraction | A, B, C | — | — |
| 4KCC | Crystal Structure of the NMDA Receptor GluN1 Ligand Binding Domain Apo State | x-ray diffraction | A | — | — |
| 4KCC | Crystal structure of the NMDA receptor GLUN1 ligand binding domain apo state | x-ray diffraction | A | — | — |
| 4KFQ | Crystal structure of the NMDA receptor GluN1 ligand binding domain in complex with… | x-ray diffraction | A, B | — | — |
| 4KFQ | Crystal structure of the NMDA receptor GLUN1 ligand binding domain in complex with… | x-ray diffraction | A, B | — | — |
| 4NF4 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate | x-ray diffraction | A | — | — |
| 4NF4 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with dcka and glutamate | x-ray diffraction | A | — | — |
| 4NF5 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 | x-ray diffraction | A | — | — |
| 4NF5 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and D-AP5 | x-ray diffraction | A | — | — |
| 4NF6 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA | x-ray diffraction | A | — | — |
| 4NF6 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and ppda | x-ray diffraction | A | — | — |
| 4NF8 | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in… | x-ray diffraction | A | — | — |
| 4NF8 | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and glutamate in… | x-ray diffraction | A | — | — |
| 4PE5 | Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel | x-ray diffraction | A, C | — | — |
| 4PE5 | Crystal structure of GLUN1A/GLUN2B NMDA receptor ion channel | x-ray diffraction | A, C | — | — |
| 5DEX | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | — | — |
| 5DEX | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | — | — |
| 5FXG | GLUN1B-GLUN2B NMDA receptor in active conformation | electron microscopy | A, C | — | — |
| 5FXG | GLUN1B-GLUN2B NMDA receptor in active conformation | electron microscopy | A, C | — | — |
| 5FXH | GluN1b-GluN2B NMDA receptor in non-active-1 conformation | electron microscopy | A, C | — | — |
| 5FXH | GLUN1B-GLUN2B NMDA receptor in non-active-1 conformation | electron microscopy | A, C | — | — |
| 5FXI | GluN1b-GluN2B NMDA receptor structure in non-active-2 conformation | electron microscopy | A, C | — | — |
| 5FXI | GLUN1B-GLUN2B NMDA receptor structure in non-active-2 conformation | electron microscopy | A, C | — | — |
| 5FXJ | GLUN1B-GLUN2B NMDA receptor structure-class X | electron microscopy | A, C | — | — |
| 5FXK | GluN1b-GluN2B NMDA receptor structure-Class Y | electron microscopy | A, C | — | — |
| 5FXK | GLUN1B-GLUN2B NMDA receptor structure-class Y | electron microscopy | A, C | — | — |
| 5I56 | Agonist-bound GLUN1/GLUN2A agonist binding domains with TCN201 | x-ray diffraction | A | — | — |
| 5I57 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains | x-ray diffraction | A | — | — |
| 5I58 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains with mpx-004 | x-ray diffraction | A | — | — |
| 5I59 | Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007 | x-ray diffraction | A | 67Q | — |
| 5I59 | Glutamate- and glycine-bound GLUN1/GLUN2A agonist binding domains with mpx 007 | x-ray diffraction | A | — | — |
| 5JTY | Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007 | x-ray diffraction | A | 2JK, 6ND | 4 (best 0.84) |
| 5JTY | Glutamate- and dcka-bound GLUN1/GLUN2A agonist binding domains with mpx-007 | x-ray diffraction | A | — | — |
| 5U8C | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and nvp-AAM077 | x-ray diffraction | A | 84J | — |
| 5U8C | Crystal structure of GLUN1/GLUN2A ligand-binding domain in complex with glycine and nvp-AAM077 | x-ray diffraction | A | 84J | — |
| 5VIH | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | — | — |
| 5VII | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | 5DY | — |
| 5VIJ | Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | GLY | 5 (best 0.81) |
| 5VIJ | Crystal structure of GLUN1/GLUN2A NMDA receptor agonist binding domains with glycine and… | x-ray diffraction | A | — | — |
| 6CNA | GLUN1-GLUN2B NMDA receptors with exon 5 | electron microscopy | A, C | NAG | — |
| 6MM9 | Diheteromeric NMDA receptor GLUN1/GLUN2A in the '1-knuckle' conformation, in complex with glycine… | electron microscopy | A, C | NAG | — |
| 6MMA | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'extended' conformation, in complex with glycine… | electron microscopy | A, C | NAG | — |
| 6MMB | Diheteromeric NMDA receptor GLUN1/GLUN2A in the 'super-splayed' conformation, in complex with… | electron microscopy | A, C | NAG | — |
65 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 39 records
- GLY · Glycine · in 9 records
- 1PC · 1-(phenyl-1-cyclohexyl)piperidine · in 2 records
- 377 · Memantine · in 2 records
- 84J · [(R)-{[(1S)-1-(4-bromophenyl)ethyl]amino}(2,3-dihydroxyquinoxalin-5-yl)methyl]phosphonic acid · in 2 records
- JC9 · (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one · in 2 records
- N9D · (3R,5S)-5-[(2R)-2-amino-2-carboxyethyl]-1-(4-propylphenyl)pyrazolidine-3-carboxylic acid · in 2 records
- QGM · (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid · in 2 records
- 2JK · 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid · in 1 record
- 5DY · 5-[(2R)-2-amino-2-carboxyethyl]-1-[4-(3-fluoropropyl) phenyl]-1H-pyrazole-3-carboxylic acid · in 1 record
- 67Q · 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-4H-1lambda~4~,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide · in 1 record
- 6ND · 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide · in 1 record
- DQC · 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile · in 1 record
Experiment against prediction
- 3Q41 chain B against the predicted model P35439: TM-score 0.98, RMSD 1.19 Å
- 3Q41 chain B against the predicted model P35439: TM-score 0.98, RMSD 1.19 Å
- 3Q41 chain A against the predicted model P35439: TM-score 0.97, RMSD 1.24 Å
- 3Q41 chain A against the predicted model P35439: TM-score 0.97, RMSD 1.24 Å
- 1Y1M chain B against the predicted model P35439: TM-score 0.97, RMSD 1.02 Å
- 1Y1M chain B against the predicted model P35439: TM-score 0.97, RMSD 1.02 Å
- 2A5T chain A against the predicted model P35439: TM-score 0.97, RMSD 1.10 Å
- 2A5T chain A against the predicted model P35439: TM-score 0.97, RMSD 1.10 Å
- 1Y1M chain A against the predicted model P35439: TM-score 0.97, RMSD 1.10 Å
- 1Y1M chain A against the predicted model P35439: TM-score 0.97, RMSD 1.10 Å
Elsewhere
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