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Ligand · 4AX

4AX · (R)-4-amino-isoxazolidin-3-one

4AX, (R)-4-amino-isoxazolidin-3-one (C3 H6 N2 O2, 102.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
4AX
Formula
C3 H6 N2 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

4AX in 4 structures; the first of them:

  • 1PB9 · Crystal structure of the NR1 ligand binding core in complex with D-cycloserine at 1.60… · 4AX A901 · binds PHE92, PRO124, LEU125, THR126, ARG131, SER179, SER180, VAL181 and 3 more
  • 1XQL · Effect of a Y265F Mutant on the Transamination Based Cycloserine Inactivation of Alanine… · 4AX A605 · binds PHE265, TYR284, CYS311, MET312, ASP313, LYS39, TYR43, ARG136 and 1 more
  • 1PB9 · Crystal structure of the NR1 ligand binding core in complex with D- cycloserine at 1.60… · 4AX A901 · binds PHE92, PRO124, LEU125, THR126, ARG131, SER179, SER180, VAL181 and 3 more
  • 1XQL · Effect of a Y265F mutant on the transamination based cycloserine inactivation of alanine… · 4AX A605 · binds PHE265, TYR284, CYS311, MET312, ASP313, LYS39, TYR43, ARG136 and 1 more

Residues it binds most

TYR 4, PHE 6, ARG 6, ASP 6, CYS 4, LYS 4, MET 4, SER 2, LEU 2, PRO 2 (residue and the binding sites it lines).

Found with

  • PLP · Pyridoxal-5'-phosphate
  • PMH · (5-hydroxy-4-{[(3-hydroxyisoxazol-4-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate
  • PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate
  • ACY · Acetic acid

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