MolNFT v1 · #18011 · protein
Crystal structure of the NR1 ligand binding core in complex with D- cycloserine at 1.60 ångströms resolution
1PB9 · N-methyl-D-aspartate receptor subunit 1: “Crystal structure of the NR1 ligand binding core in complex with D- cycloserine at 1.60 ångströms resolution”. X-ray diffraction, 1 ligand (4AX), 4 pockets (best druggability 0.48). MolNFT…
- PDB
- 1PB9
- Type
- protein
- Length
- 281 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-methyl-D-aspartate receptor subunit 1
- UniProt
- P35439
- Ligands
- 4AX
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-methyl-D-aspartate receptor subunit 1 | protein | 281 | 30% helix, 27% strand | P35439 |
Ligands and binding sites
- 4AX · (R)-4-amino-isoxazolidin-3-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.48 | 0.78 | 30 | empty |
| 2 | 89 | 0.37 | 0.76 | 19 | empty |
| 3 | 52 | 0.33 | 0.78 | 13 | empty |
| 4 | 52 | 0.28 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1PB9 · Crystal structure of the NR1 ligand binding core in complex with D-cycloserine at 1.60… · the same entry in another collection · chain A against A, TM-score 1.00
- P35439 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (P35439) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35439
- Elsewhere: RCSB PDB 1PB9 · PDBe 1PB9 · UniProt P35439
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