UniProt P35408
Prostaglandin E2 receptor EP4 subtype (P35408)
Prostaglandin E2 receptor EP4 subtype (UniProt P35408): 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35408
- Protein
- Prostaglandin E2 receptor EP4 subtype
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 32 · 5 records with a druggable one
Structures
9 records of P35408 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5YHL | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and an antagonist… | x-ray diffraction | A | 8VL | — |
| 5YWY | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208 | x-ray diffraction | A | 7UR | 5 (best 0.80) |
| 5YWY | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ono-AE3-208 | x-ray diffraction | A | 7UR | — |
| 7D7M | Cryo-EM structure of the prostaglandin E receptor EP4 coupled to G protein | electron microscopy | A | P2E | — |
| 8GCM | Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein | electron microscopy | R | YX9 | 7 (best 0.74) |
| 8GCP | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | electron microscopy | R | P2E | 6 (best 0.82) |
| 8GD9 | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | electron microscopy | R | Z2C | 7 (best 0.84) |
| 8GDB | Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein | electron microscopy | R | P2E | — |
| P35408 | AlphaFold monomer V2.0 prediction for prostaglandin E2 receptor EP4 subtype (P35408) | predicted | A | — | 7 (best 0.82) |
Ligands
- P2E · (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid · in 3 records
- 7UR · 4-[4-cyano-2-[[(2R)-2-(4-fluoranylnaphthalen-1-yl) propanoyl]amino]phenyl]butanoic acid · in 2 records
- 8VL · 4-[2-[[(2R)-2-(4-bromanylnaphthalen-1-yl) propanoyl]amino]-4-cyano-phenyl]butanoic acid · in 1 record
- YX9 · (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one · in 1 record
- Z2C · 4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid · in 1 record
Experiment against prediction
- 5YHL chain A against the predicted model P35408: TM-score 0.96, RMSD 1.54 Å
- 5YWY chain A against the predicted model P35408: TM-score 0.96, RMSD 1.54 Å
- 5YWY chain A against the predicted model P35408: TM-score 0.96, RMSD 1.54 Å
- 8GCP chain R against the predicted model P35408: TM-score 0.92, RMSD 2.11 Å
- 8GD9 chain R against the predicted model P35408: TM-score 0.92, RMSD 1.97 Å
- 8GDB chain R against the predicted model P35408: TM-score 0.91, RMSD 2.02 Å
- 8GCM chain R against the predicted model P35408: TM-score 0.90, RMSD 2.29 Å
- 7D7M chain A against the predicted model P35408: TM-score 0.89, RMSD 2.36 Å
Elsewhere
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