P2E · (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid

Binding sites

P2E in 9 structures; the first of them:

• 6AK3 · Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 · P2E B1201 · binds PRO55, MET58, ASP99, GLY102, GLN103, THR106, THR107, VAL110 and 16 more
• 7CX2 · Cryo-EM structure of the PGE2-bound EP2-Gs complex · P2E R401 · binds GLU23, SER28, MET31, PHE32, GLY81, THR82, ILE85, SER86 and 15 more
• 8BWR · Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with… · P2E A1401 · binds PHE156, ARG362, LEU363, LEU367, PHE368, THR846, ARG946, GLY991 and 4 more
• 8GCP · Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein · P2E R501 · binds PRO24, MET27, PHE28, GLY68, THR69, VAL72, SER73, THR76 and 11 more
• 8GDB · Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein · P2E R501 · binds PRO24, MET27, GLY68, THR69, SER73, THR76, TYR80, LEU99 and 8 more
• 8GDC · Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein · P2E R401 · binds PRO55, MET58, GLY102, GLN103, THR106, THR107, TYR114, MET137 and 9 more
• 6AK3 · Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 · P2E B1201 · binds PRO55, MET58, GLN103, THR106, THR107, VAL110, TYR114, MET137 and 10 more
• 7CX2 · Cryo-EM structure of the PGE2-bound EP2-gs complex · P2E R401 · binds SER28, MET31, THR82, ILE85, SER86, VAL89, TYR93, MET116 and 9 more
• 7D7M · Cryo-EM structure of the prostaglandin E receptor EP4 coupled to G protein · P2E A401 · binds PRO24, MET27, GLY68, THR69, VAL72, SER73, THR76, TYR80 and 11 more

Residues it binds most

THR 11, SER 10, LEU 10, MET 11, ARG 11, GLY 10, PRO 8, TRP 9, VAL 9, GLN 6 (residue and the binding sites it lines).

Found with

• POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate