UniProt P32324
yeast eEF2 (P32324)
yeast eEF2 (UniProt P32324): 43 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P32324
- Protein
- yeast eEF2
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 5
Structures
44 records of P32324 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1N0U | Crystal structure of yeast elongation factor 2 in complex with sordarin | x-ray diffraction | A | — | — |
| 1N0U | Crystal structure of yeast elongation factor 2 in complex with sordarin | x-ray diffraction | A | — | — |
| 1N0V | Crystal structure of elongation factor 2 | x-ray diffraction | C, D | — | — |
| 1N0V | Crystal structure of elongation factor 2 | x-ray diffraction | C, D | — | — |
| 1U2R | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae | x-ray diffraction | A | — | — |
| 1U2R | Crystal structure of ADP-ribosylated ribosomal translocase from saccharomyces cerevisiae | x-ray diffraction | A | — | — |
| 1ZM2 | Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA | x-ray diffraction | A, C, E | — | — |
| 1ZM2 | Structure of ADP-ribosylated EEF2 in complex with catalytic fragment of eta | x-ray diffraction | A, C, E | — | — |
| 1ZM3 | Structure of the apo eEF2-ETA complex | x-ray diffraction | A, C, E | — | — |
| 1ZM3 | Structure of the apo EEF2-eta complex | x-ray diffraction | A, C, E | — | — |
| 1ZM4 | Structure of the eEF2-ETA-bTAD complex | x-ray diffraction | A, C, E | — | — |
| 1ZM4 | Structure of the EEF2-eta-btad complex | x-ray diffraction | A, C, E | — | — |
| 1ZM9 | Structure of eEF2-ETA in complex with PJ34 | x-ray diffraction | A, C, E | — | — |
| 1ZM9 | Structure of EEF2-eta in complex with PJ34 | x-ray diffraction | A, C, E | — | — |
| 2E1R | Structure of eEF2 in complex with a sordarin derivative | x-ray diffraction | A | — | — |
| 2E1R | Structure of EEF2 in complex with a sordarin derivative | x-ray diffraction | A | — | — |
| 2NPF | Structure of eEF2 in complex with moriniafungin | x-ray diffraction | A, B | — | — |
| 2NPF | Structure of EEF2 in complex with moriniafungin | x-ray diffraction | A, B | — | — |
| 2P8W | Fitted structure of eEF2 in the 80S:eEF2:GDPNP cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8W | Fitted structure of EEF2 in the 80S:EEF2:GDPNP cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8X | Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8X | Fitted structure of adpr-EEF2 in the 80S:ADPR-EEF2:GDPNP cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8Y | Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDP:sordarin cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8Y | Fitted structure of adpr-EEF2 in the 80S:ADPR-EEF2:GDP:SORDARIN cryo- EM reconstruction | electron microscopy | T | — | — |
| 2P8Z | Fitted structure of ADPR-eEF2 in the 80S:ADPR-eEF2:GDPNP:sordarin cryo-EM reconstruction | electron microscopy | T | — | — |
| 2P8Z | Fitted structure of adpr-EEF2 in the 80S:ADPR-EEF2:GDPNP:SORDARIN cryo-EM reconstruction | electron microscopy | T | — | — |
| 2ZIT | Structure of the eEF2-ExoA-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 2ZIT | Structure of the EEF2-exoa-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B78 | Structure of the eEF2-ExoA(R551H)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B78 | Structure of the EEF2-EXOA(R551H)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B82 | Structure of the eEF2-ExoA(E546H)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B82 | Structure of the EEF2-EXOA(E546H)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B8H | Structure of the eEF2-ExoA(E546A)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3B8H | Structure of the EEF2-EXOA(E546A)-NAD+ complex | x-ray diffraction | A, C, E | — | — |
| 3DNY | Fitting of the eEF2 crystal structure into the cryo-EM density map of the eEF2.80S.AlF4-.GDP complex | electron microscopy | T | — | — |
| 3DNY | Fitting of the EEF2 crystal structure into the cryo-EM density MAP of the EEF2.80S.ALF4-.GDP complex | electron microscopy | T | — | — |
| 4V4B | Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models… | electron microscopy | AT | — | — |
| 5JUP | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | DC | GDP, MG, SO1 | — |
| 5JUS | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | DC | GDP, MG, SO1 | — |
| 5JUU | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura… | electron microscopy | DC | GDP, MG, SO1 | — |
| 6GQ1 | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | electron microscopy | AZ | SO1, GCP | — |
| 6GQB | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | electron microscopy | AZ | SO1, GDP, ALF | — |
| 6GQV | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | electron microscopy | AX | GCP | — |
| P32324 | AlphaFold monomer V2.0 prediction for elongation factor 2 (P32324) | predicted | A | — | — |
Ligands
- SO1 · [1R-(1.alpha.,3a.beta.,4.beta.,4a.beta.,7.beta.,7a.alpha.,8a.beta.)]8a-[(6-deoxy-4-O-methyl-beta-D-altropyranosyloxy)methyl]-4-formyl-4,4A,5,6,7,7A,8,8A-octahydro-7-methyl-3-(1-methylethyl)-1,4-methano-S-indacene-3A(1H)-carboxylic acid · in 5 records
- GDP · Guanosine-5'-diphosphate · in 4 records
- MG · Magnesium ion · in 3 records
- GCP · Phosphomethylphosphonic acid guanylate ester · in 2 records
- ALF · Tetrafluoroaluminate ion · in 1 record
Experiment against prediction
- 5JUP chain DC against the predicted model P32324: TM-score 0.73, RMSD 4.57 Å
- 5JUS chain DC against the predicted model P32324: TM-score 0.73, RMSD 4.67 Å
- 5JUU chain DC against the predicted model P32324: TM-score 0.73, RMSD 4.67 Å
- 3DNY chain T against the predicted model P32324: TM-score 0.73, RMSD 3.74 Å
- 3DNY chain T against the predicted model P32324: TM-score 0.73, RMSD 3.74 Å
- 6GQV chain AX against the predicted model P32324: TM-score 0.72, RMSD 4.73 Å
- 6GQ1 chain AZ against the predicted model P32324: TM-score 0.72, RMSD 4.68 Å
- 6GQB chain AZ against the predicted model P32324: TM-score 0.71, RMSD 4.85 Å
- 2P8Z chain T against the predicted model P32324: TM-score 0.71, RMSD 4.66 Å
- 2P8Z chain T against the predicted model P32324: TM-score 0.71, RMSD 4.66 Å
Elsewhere
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