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Ligand · TAD

TAD · Beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide

TAD, Beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide (C20 H27 N7 O13 P2 S, 667.5 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues…

Component
TAD
Formula
C20 H27 N7 O13 P2 S
Class
ligand
Structures
6
PDB entries
6

Binding sites

TAD in 6 structures; the first of them:

  • 1ADF · Crystallographic studies of two alcohol dehydrogenase-bound analogs of… · TAD A378 · binds ARG47, HIS51, GLY199, LEU200, GLY201, GLY202, VAL203, VAL222 and 15 more
  • 1AER · Domain III of pseudomonas aeruginosa exotoxin complexed with beta-tad · TAD A700 · binds TYR439, HIS440, GLY441, THR442, PHE443, ALA446, SER449, ILE450 and 12 more
  • 1KR2 · Crystal structure of human NMN/NAMN adenylyl transferase complexed with tiazofurin… · TAD A809 · binds CYS14, GLY15, SER16, PHE17, MET23, HIS24, LEU27, VAL51 and 21 more
  • 1LRT · Crystal structure of ternary complex of tritrichomonas foetus inosine-5'-monophosphate… · TAD A901 · binds ILE58, THR240, ARG241, ASP261, SER262, SER263, ASP264, TRP269 and 7 more
  • 1OG1 · Crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2 in complex with tad · TAD A1227 · binds LEU5, MET6, TYR78, THR79, GLY80, ALA83, VAL84, ASN87 and 14 more
  • 1ZM4 · Structure of the eEF2-ETA-bTAD complex · TAD B700 · binds TYR439, HIS440, GLY441, THR442, PHE443, ALA446, SER449, ILE450 and 12 more

Residues it binds most

GLY 16, LEU 9, SER 15, GLU 15, ASP 11, VAL 12, THR 16, TYR 11, TRP 13, ILE 11 (residue and the binding sites it lines).

Found with

  • AMP · Adenosine monophosphate
  • IMP · Inosinic acid
  • TIA · 2-(1,5-dideoxyribose)-4-amido-thiazole
  • K · Potassium ion
  • ZN · Zinc ion
  • BOG · octyl beta-D-glucopyranoside
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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