UniProt P32238
Cholecystokinin receptor type A (P32238)
Cholecystokinin receptor type A (UniProt P32238), EC 3.2.1.17: 21 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P32238
- Protein
- Cholecystokinin receptor type A
- EC
- 3.2.1.17
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 28 · 7 records with a druggable one
Structures
22 records of P32238 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D6G | Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin a receptor by NMR… | solution nmr | A | — | — |
| 1D6G | Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin a receptor by NMR… | solution nmr | A | — | — |
| 1HZN | NMR solution structure of the third extracellular loop of the cholecystokinin a receptor | solution nmr | A | — | — |
| 1HZN | NMR solution structure of the third extracellular loop of the cholecystokinin a receptor | solution nmr | A | — | — |
| 7EZH | Cryo-EM structure of an activated cholecystokinin a receptor (cckar)- gi complex | electron microscopy | D | — | — |
| 7EZK | Cryo-EM structure of an activated cholecystokinin a receptor (cckar)- gs complex | electron microscopy | D | — | — |
| 7EZM | Cryo-EM structure of an activated cholecystokinin a receptor (cckar)- gq complex | electron microscopy | D | — | — |
| 7F8U | Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript | x-ray diffraction | A | 1OE | 5 (best 0.80) |
| 7F8U | Crystal structure of the cholecystokinin receptor cckar in complex with lintitript | x-ray diffraction | A | — | — |
| 7F8X | Crystal structure of the cholecystokinin receptor cckar in complex with NN9056 | x-ray diffraction | A | NH2 | — |
| 7F8Y | Crystal structure of the cholecystokinin receptor cckar in complex with devazepide | x-ray diffraction | A | — | — |
| 7MBX | Human Cholecystokinin 1 receptor (CCK1R) Gs complex | electron microscopy | R | Y01 | 5 (best 0.78) |
| 7MBX | Human cholecystokinin 1 receptor (CCK1R) gs complex | electron microscopy | R | NH2, Y01 | — |
| 7MBY | Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex | electron microscopy | R | Y01 | 4 (best 0.71) |
| 7MBY | Human cholecystokinin 1 receptor (CCK1R) gq chimera (mgsqi) complex | electron microscopy | R | NH2, Y01 | — |
| 7XOU | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | R | — | 4 (best 0.74) |
| 7XOU | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | R | NH2 | — |
| 7XOV | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | R | IA1 | 4 (best 0.81) |
| 7XOV | Structural insights into human brain gut peptide cholecystokinin receptors | electron microscopy | R | IA1 | — |
| 9BKJ | Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex | electron microscopy | R | NH2 | 2 (best 0.69) |
| 9BKK | Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex | electron microscopy | R | — | 4 (best 0.68) |
| P32238 | AlphaFold monomer V2.0 prediction for cholecystokinin receptor type a (P32238) | predicted | A | — | — |
Ligands
- NH2 · Amino group · in 5 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- IA1 · 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid · in 2 records
- 1OE · 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid · in 1 record
Experiment against prediction
- 9BKJ chain R against the predicted model P32238: TM-score 0.94, RMSD 1.89 Å
- 9BKK chain R against the predicted model P32238: TM-score 0.94, RMSD 1.88 Å
- 7MBY chain R against the predicted model P32238: TM-score 0.94, RMSD 1.90 Å
- 7MBY chain R against the predicted model P32238: TM-score 0.94, RMSD 1.90 Å
- 7MBX chain R against the predicted model P32238: TM-score 0.94, RMSD 1.86 Å
- 7MBX chain R against the predicted model P32238: TM-score 0.94, RMSD 1.86 Å
- 7EZH chain D against the predicted model P32238: TM-score 0.94, RMSD 1.91 Å
- 7EZK chain D against the predicted model P32238: TM-score 0.93, RMSD 1.87 Å
- 7EZM chain D against the predicted model P32238: TM-score 0.92, RMSD 2.09 Å
- 7XOU chain R against the predicted model P32238: TM-score 0.92, RMSD 1.98 Å
Elsewhere
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