UniProt P29401
Transketolase (P29401)
Transketolase (UniProt P29401), EC 2.2.1.1: 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29401
- Protein
- Transketolase
- EC
- 2.2.1.1
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 72 · 3 records with a druggable one
Structures
24 records of P29401 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3MOS | The structure of human Transketolase | x-ray diffraction | A | — | — |
| 3MOS | The structure of human transketolase | x-ray diffraction | A | — | — |
| 3OOY | Crystal structure of human Transketolase (TKT) | x-ray diffraction | A, B | — | — |
| 3OOY | Crystal structure of human transketolase (tkt) | x-ray diffraction | A, B | — | — |
| 4KXU | Human transketolase in covalent complex with donor ketose D-fructose-6-phosphate | x-ray diffraction | A | — | — |
| 4KXU | Human transketolase in covalent complex with donor ketose D-fructose- 6-phosphate | x-ray diffraction | A | — | — |
| 4KXV | Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 1 | x-ray diffraction | A | — | — |
| 4KXV | Human transketolase in covalent complex with donor ketose D-xylulose- 5-phosphate, crystal 1 | x-ray diffraction | A | — | — |
| 4KXW | Human transketolase in covalent complex with donor ketose D-xylulose-5-phosphate, crystal 2 | x-ray diffraction | A | — | — |
| 4KXW | Human transketolase in covalent complex with donor ketose D-xylulose- 5-phosphate, crystal 2 | x-ray diffraction | A | — | — |
| 4KXX | Human transketolase in covalent complex with donor ketose D-sedoheptulose-7-phosphate | x-ray diffraction | A | — | — |
| 4KXX | Human transketolase in covalent complex with donor ketose D- sedoheptulose-7-phosphate | x-ray diffraction | A | — | — |
| 4KXY | Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP | x-ray diffraction | A, B | — | — |
| 4KXY | Human transketolase in complex with thdp analogue (R)-2-(1,2- dihydroxyethyl)-3-deaza-thdp | x-ray diffraction | A, B | — | — |
| 6HA3 | Human transketolase variant E160Q in covalent complex with donor ketose D-fructose-6-phosphate | x-ray diffraction | A | T6F, NA, CA, MG | — |
| 6HA3 | Human transketolase variant E160Q in covalent complex with donor ketose D-fructose-6-phosphate | x-ray diffraction | A | T6F, NA, CA, MG | — |
| 6HAD | Human transketolase variant E160Q | x-ray diffraction | A | NA, CA, MG, TPP | 6 (best 0.45) |
| 6HAD | Human transketolase variant E160Q | x-ray diffraction | A | NA, CA, MG, TPP | — |
| 6RJB | Human transketolase variant T382E | x-ray diffraction | A, B | TPP, MG, CA, NA | 18 (best 0.75) |
| 6RJB | Human transketolase variant T382E | x-ray diffraction | A, B | TPP, MG, CA, NA | — |
| 8WA8 | Human transketolase in complex with phosphite | x-ray diffraction | A | CA, TPP | 6 (best 0.46) |
| 8WA9 | Human transketolase soaked with donor ketose D-fructose | x-ray diffraction | A, B | CA, THD | 19 (best 0.75) |
| 8WAA | Human transketolase soaked with donor ketose D-xylulose | x-ray diffraction | A, B | CA, 3GR, THD | 18 (best 0.75) |
| P29401 | AlphaFold monomer V2.0 prediction for transketolase (P29401) | predicted | A | — | 5 (best 0.39) |
Ligands
- CA · Calcium ion · in 9 records
- MG · Magnesium ion · in 6 records
- NA · Sodium ion · in 6 records
- TPP · Thiamine diphosphate · in 5 records
- T6F · 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol · in 2 records
- THD · 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-2-(1,2-dihydroxyethyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl trihydrogen diphosphate · in 2 records
- 3GR · D-Glyceraldehyde · in 1 record
Experiment against prediction
- 6HAD chain A against the predicted model P29401: TM-score 1.00, RMSD 0.57 Å
- 6HAD chain A against the predicted model P29401: TM-score 1.00, RMSD 0.57 Å
- 3OOY chain A against the predicted model P29401: TM-score 1.00, RMSD 0.56 Å
- 3OOY chain A against the predicted model P29401: TM-score 1.00, RMSD 0.56 Å
- 3MOS chain A against the predicted model P29401: TM-score 1.00, RMSD 0.61 Å
- 3MOS chain A against the predicted model P29401: TM-score 1.00, RMSD 0.61 Å
- 8WA8 chain A against the predicted model P29401: TM-score 0.99, RMSD 0.71 Å
- 6RJB chain B against the predicted model P29401: TM-score 0.99, RMSD 0.71 Å
- 6RJB chain B against the predicted model P29401: TM-score 0.99, RMSD 0.71 Å
- 8WA9 chain A against the predicted model P29401: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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