Ligand · THD
THD · 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-2-(1,2-dihydroxyethyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl trihydrogen diphosphate
THD, 2-[3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-2-(1,2-dihydroxyethyl)-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl trihydrogen diphosphate (C14 H22 N4 O9 P2 S, 484.4 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (5 PDB…
- Component
- THD
- Formula
- C14 H22 N4 O9 P2 S
- Class
- ligand
- Structures
- 5
- PDB entries
- 5
Binding sites
THD in 5 structures; the first of them:
- 1GPU · Transketolase complex with reaction intermediate · THD A1682 · binds HIS30, ALA33, HIS69, HIS103, GLY116, PRO117, LEU118, GLY156 and 19 more
- 3AHE · Phosphoketolase from Bifidobacterium Breve complexed with dihydroxyethyl thiamine… · THD A827 · binds THR67, PRO95, HIS97, HIS142, GLY154, GLY155, GLU156, LEU157 and 12 more
- 8WA7 · E.coli transketolase soaked with donor ketose D-fructose · THD A713 · binds HIS26, ALA29, HIS66, HIS100, GLY114, PRO115, LEU116, GLY154 and 18 more
- 8WA9 · Human transketolase soaked with donor ketose D-fructose · THD A702 · binds HIS37, SER40, SER43, LYS75, HIS77, HIS110, GLY123, SER124 and 23 more
- 8WAA · Human transketolase soaked with donor ketose D-xylulose · THD A703 · binds HIS37, SER40, SER43, LYS75, HIS77, HIS110, GLY123, SER124 and 23 more
Residues it binds most
HIS 9, GLY 9, ASP 9, GLU 9, ILE 9, LEU 9, PHE 8, SER 6, LYS 5, ASN 9 (residue and the binding sites it lines).
Found with
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