UniProt P29375
Lysine-specific demethylase 5A (P29375)
Lysine-specific demethylase 5A (UniProt P29375), EC 1.14.11.-, 1.14.11.67: 74 experimental structures on GenesisL1, 41 ligands bound, 32 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P29375
- Protein
- Lysine-specific demethylase 5A
- EC
- 1.14.11.-, 1.14.11.67
- Experimental structures
- 74
- Predicted models
- 0
- Ligands
- 41
- Pockets
- 32 · 12 records with a druggable one
Structures
74 records of P29375 in the MolNFT archive: 74 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JXJ | NMR structure of the ARID domain from the histone H3K4 demethylase RBP2 | solution nmr | A | — | — |
| 2JXJ | NMR structure of the arid domain from the histone H3K4 demethylase RBP2 | solution nmr | A | — | — |
| 2KGG | Solution Structure of JARID1A C-terminal PHD finger | solution nmr | A | — | — |
| 2KGG | Solution structure of JARID1A C-terminal phd finger | solution nmr | A | — | — |
| 2KGI | Solution structure of JARID1A C-terminal PHD finger in complex with H3(1-9)K4me3 | solution nmr | A | — | — |
| 2KGI | Solution structure of JARID1A C-terminal phd finger in complex with H3(1-9)K4ME3 | solution nmr | A | — | — |
| 3GL6 | Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide | x-ray diffraction | A | — | — |
| 3GL6 | Crystal structure of JARID1A-PHD3 complexed with H3(1-9) K4ME3 peptide | x-ray diffraction | A | — | — |
| 5C11 | Crystal Structure of Jarid1a PHD finger bound to histone H3C4me3 peptide | x-ray diffraction | A | — | — |
| 5C11 | Crystal structure of JARID1A phd finger bound to histone H3C4ME3 peptide | x-ray diffraction | A | — | — |
| 5CEH | Structure of histone lysine demethylase KDM5A in complex with selective inhibitor | x-ray diffraction | A | — | — |
| 5E6H | A Linked Jumonji Domain of the KDM5A Lysine Demethylase | x-ray diffraction | A | MN, AKG | 3 (best 0.67) |
| 5E6H | A linked jumonji domain of the KDM5A lysine demethylase | x-ray diffraction | A | — | — |
| 5ISL | Linked KDM5A Jmj Domain Bound to the Inhibitor C49 (2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)ami… | x-ray diffraction | A | MN | — |
| 5ISL | Linked KDM5A jmj domain bound to the inhibitor C49 (2-{[(2-{[(E)-2… | x-ray diffraction | A | — | — |
| 5IVB | A High Resolution Structure of a Linked KDM5A Jmj Domain with Alpha-Ketoglutarate | x-ray diffraction | A | AKG, MN | — |
| 5IVB | A high resolution structure of a linked KDM5A jmj domain with alpha- ketoglutarate | x-ray diffraction | A | — | — |
| 5IVC | Linked KDM5A Jmj Domain Bound to the Inhibitor N3 (4'-[(2-phenylethyl)carbamoyl][2,2'-bipyridine]-4… | x-ray diffraction | A | 6E7, MN | 3 (best 0.65) |
| 5IVC | Linked KDM5A jmj domain bound to the inhibitor N3 (4'-[(2… | x-ray diffraction | A | — | — |
| 5IVE | Linked KDM5A Jmj Domain Bound to the Inhibitor N8 (… | x-ray diffraction | A | 6E8, MN | — |
| 5IVE | Linked KDM5A jmj domain bound to the inhibitor N8 ( 5-methyl-7-oxo-6… | x-ray diffraction | A | — | — |
| 5IVF | Linked KDM5A Jmj Domain Bound to the Inhibitor N10 8-(1-methyl-1H-imidazol-4-yl)-2-(4,4,4-trifluorob… | x-ray diffraction | A | 6EB, MN | 3 (best 0.68) |
| 5IVF | Linked KDM5A jmj domain bound to the inhibitor N10 8-(1-methyl-1H… | x-ray diffraction | A | — | — |
| 5IVJ | Linked KDM5A Jmj Domain Bound to the Inhibitor N11 [3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fl… | x-ray diffraction | A | 6ED, MN | 3 (best 0.65) |
| 5IVJ | Linked KDM5A jmj domain bound to the inhibitor N11 [3-({1-[2-(4,4… | x-ray diffraction | A | — | — |
| 5IVV | Linked KDM5A Jmj Domain Bound to the Inhibitor N12 [3-((1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)amino… | x-ray diffraction | A | 6EN, MN | 2 (best 0.65) |
| 5IVV | Linked KDM5A jmj domain bound to the inhibitor N12 [3-((1-methyl-1H… | x-ray diffraction | A | — | — |
| 5IVY | Linked KDM5A Jmj Domain Bound to the Inhibitor N16 [3-(2-(4-chlorophenyl)acetamido)isonicotinic… | x-ray diffraction | A | 6EO, MN | — |
| 5IVY | Linked KDM5A jmj domain bound to the inhibitor N16 [3-(2-(4- CHLOROPHENYL)ACETAMIDO)ISONICOTINIC… | x-ray diffraction | A | — | — |
| 5IW0 | Linked KDM5A Jmj Domain Bound to the Inhibitor N19 [2-(5-((4-chloro-2-methylbenzyl)oxy)-1H-pyrazol-1… | x-ray diffraction | A | 6EP, AKG, MN | 3 (best 0.67) |
| 5IW0 | Linked KDM5A jmj domain bound to the inhibitor N19 [2-(5-((4-chloro-2… | x-ray diffraction | A | — | — |
| 5IWF | Linked KDM5A Jmj Domain Bound to the Inhibitor 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoet… | x-ray diffraction | A | LQT, MN | — |
| 5IWF | Linked KDM5A jmj domain bound to the inhibitor 2-(((2-((2… | x-ray diffraction | A | — | — |
| 5K4L | Crystal structure of KDM5A in complex with a naphthyridone inhibitor | x-ray diffraction | A, B | NI, ZN, 6QN | — |
| 5K4L | Crystal structure of KDM5A in complex with a naphthyridone inhibitor | x-ray diffraction | A, B | NI, ZN, 6QN | — |
| 5V9P | Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H… | x-ray diffraction | A | NI, ZN, 90S, SO4 | — |
| 5V9T | Crystal structure of selective pyrrolidine amide KDM5A inhibitor N… | x-ray diffraction | A, B | NI, ZN, 90V | — |
| 6BGU | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 2-((2-chlorophenyl)(propoxy)methyl)-1H-pyrrolo[3,2-b]… | x-ray diffraction | A | DKP, MN, SO4 | 2 (best 0.67) |
| 6BGU | Linked KDM5A jmj domain bound to the inhibitor 2-((2-chlorophenyl)… | x-ray diffraction | A | DKP, MN, SO4 | — |
| 6BGV | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)(2… | x-ray diffraction | A | DQG, MN | — |
| 6BGW | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)(2… | x-ray diffraction | A | DKS, MN | — |
| 6BGX | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)((4… | x-ray diffraction | A | DKV, MN | — |
| 6BGY | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)(2… | x-ray diffraction | A | DLJ, MN | — |
| 6BGZ | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)(2… | x-ray diffraction | A | DNV, MN | — |
| 6BH0 | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR (R)-2-((2-chlorophenyl)(2-(piperidin-1-yl)ethoxy)meth… | x-ray diffraction | A | DO1, MN | — |
| 6BH0 | Linked KDM5A jmj domain bound to the inhibitor (R)-2-((2… | x-ray diffraction | A | DO1, MN | — |
| 6BH1 | Linked KDM5A jmj domain bound to the inhibitor (S)-2-((2… | x-ray diffraction | A | DQG, MN | — |
| 6BH2 | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR (R)-N-(1-(3-isopropyl-1H-pyrazole-5-carbonyl)pyrrolid… | x-ray diffraction | A | MN, 90V | — |
| 6BH2 | Linked KDM5A jmj domain bound to the inhibitor (R)-N-(1-(3-isopropyl… | x-ray diffraction | A | MN, 90V | — |
| 6BH3 | Linked KDM5A jmj domain bound to the inhibitor (S)-N-(1-(3-isopropyl… | x-ray diffraction | A | DQJ, MN | — |
| 6BH4 | Linked KDM5A jmj domain bound to the inhibitor 5-(1-(tert-butyl)-1H… | x-ray diffraction | A | DQS, MN | — |
| 6BH5 | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR 2-((2-chlorophenyl)(3-(piperidin-1-yl)propoxy)methyl)… | x-ray diffraction | A | DNY, MN | — |
| 6BH5 | Linked KDM5A jmj domain bound to the inhibitor 2-((2-CHLOROPHENYL)(3… | x-ray diffraction | A | DNY, MN | — |
| 6DQ4 | Linked KDM5A jmj domain bound to the inhibitor gsk-J1 | x-ray diffraction | A | K0I, MN, SO4 | 3 (best 0.64) |
| 6DQ4 | Linked KDM5A jmj domain bound to the inhibitor gsk-J1 | x-ray diffraction | A | K0I, MN, SO4 | — |
| 6DQ5 | Linked KDM5A jmj domain bound to the inhibitor N43 I.E. 3-((6-(4… | x-ray diffraction | A | H6G, MN | — |
| 6DQ6 | LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N44 i.e.… | x-ray diffraction | A | H6J, MN | 3 (best 0.67) |
| 6DQ6 | Linked KDM5A jmj domain bound to the inhibitor N44 I.E. 3-((2… | x-ray diffraction | A | H6J, MN | — |
| 6DQ7 | Linked KDM5A jmj domain bound to the potential hydrolysis product of inhibitor N45 I.E.… | x-ray diffraction | A | H6M, MN | — |
| 6DQ8 | Linked KDM5A jmj domain bound to the inhibitor N49 I.E. 2-((2… | x-ray diffraction | A | H6S, H6T, MN, SO4 | — |
14 records more on the page itself.
Ligands
- MN · Manganese (II) ion · in 44 records
- SO4 · Sulfate ion · in 7 records
- ZN · Zinc ion · in 7 records
- NI · Nickel (II) ion · in 4 records
- 90V · N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide · in 3 records
- AKG · 2-oxoglutaric acid · in 3 records
- 6QN · ~{N}-ethyl-4-oxidanyl-2-oxidanylidene-1~{H}-1,7-naphthyridine-3-carboxamide · in 2 records
- DKP · 2-[(R)-(2-chlorophenyl)(propoxy)methyl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 2 records
- DNY · 2-{(S)-(2-chlorophenyl)[3-(piperidin-1-yl) propoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 2 records
- DO1 · 2-{(R)-(2-chlorophenyl)[2-(piperidin-1-yl) ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 2 records
- DQG · 2-{(S)-(2-chlorophenyl)[2-(piperidin-1-yl) ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 2 records
- H61 · 2-{1-[2-(piperidin-1-yl)ethyl]-1H-benzimidazol-2-yl}thieno[3,2-b]pyridine-7-carboxylic acid · in 2 records
- H67 · 2-[5-([1,1'-biphenyl]-3-yl)-4-{(1S)-1-[2-(piperidin-1-yl)ethoxy]ethyl}-1H-pyrazol-1-yl]pyridine-4-carboxylic acid · in 2 records
- H6A · 2-(5-phenyl-4-{(R)-phenyl[2-(piperidin-1-yl) ethoxy]methyl}-1H-pyrazol-1-yl)pyridine-4-carboxylic acid · in 2 records
- H6J · N-{6-[4-(ethenylsulfonyl)-1,4-diazepan-1-yl]-2-(pyridin-2-yl)pyrimidin-4-yl}-beta-alanine · in 2 records
- K0I · 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid · in 2 records
- 6E7 · 4'-[(2-phenylethyl)carbamoyl][2,2'-bipyridine]-4-carboxylic acid · in 1 record
- 6E8 · 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile · in 1 record
- 6EB · 8-(1-methyl-1H-imidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol · in 1 record
- 6ED · 3-({1-[2-(4,4-difluoropiperidin-1-yl)ethyl]-5-fluoro-1H-indazol-3-yl}amino)pyridine-4-carboxylic acid · in 1 record
- 6EN · 3-[(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)amino]pyridine-4-carboxylic acid · in 1 record
- 6EO · 3-{[(4-chlorophenyl)acetyl]amino}pyridine-4-carboxylic acid · in 1 record
- 6EP · 2-{5-[(4-chloro-2-methylphenyl)methoxy]-1H-pyrazol-1-yl}pyridine-4-carboxylic acid · in 1 record
- 90S · [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone · in 1 record
- DKS · 2-{(S)-(2-chlorophenyl)[2-(4,4-difluoropiperidin-1-yl) ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 1 record
- DKV · 2-{(S)-(2-chlorophenyl)[(4,4-difluorocyclohexyl) methoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 1 record
- DLJ · 2-[(S)-(2-chlorophenyl){2-[(2R)-1-methylpyrrolidin-2-yl]ethoxy}methyl]-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 1 record
- DNV · 2-{(S)-(2-chlorophenyl)[2-(1-methyl-1H-imidazol-2-yl) ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid · in 1 record
- DQJ · N-{(3S)-1-[5-(propan-2-yl)-1H-pyrazole-3-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide · in 1 record
- DQS · 5-(1-tert-butyl-1H-pyrazol-4-yl)-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile · in 1 record
Elsewhere
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