MolNFT v1 · #144028 · protein

Linked KDM5A jmj domain bound to the inhibitor (S)-N-(1-(3-isopropyl- 1H-pyrazole-5-CARBONYL)PYRROLIDIN-3-YL)CYCLOPROPANECARBOXAMIDE (compound N55)

6BH3: “Linked KDM5A jmj domain bound to the inhibitor (S)-N-(1-(3-isopropyl…”. X-ray diffraction, 2 ligands (DQJ, MN). MolNFT v1 #144028 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6BH3
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P29375
Ligands: DQJ, MN

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	302	—	P29375

Ligands and binding sites

DQJ · N-{(3S)-1-[5-(propan-2-yl)-1H-pyrazole-3-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide · ligand · chains A
MN · Manganese (II) ion · metal · chains A
EDO · 1,2-ethanediol · additive · 5 copies · chains A
GOL · Glycerol · additive · 2 copies · chains A
DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6BH3 · LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR… · the same entry in another collection · chain A against A, TM-score 1.00
P29375 · AlphaFold monomer V2.0 prediction for lysine-specific demethylase 5A (P29375) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29375
Elsewhere: RCSB PDB 6BH3 · PDBe 6BH3 · UniProt P29375

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.