UniProt P27708
CAD protein (P27708)
CAD protein (UniProt P27708), EC 2.1.3.2, 3.5.1.2: 85 experimental structures on GenesisL1, 8 ligands bound, 76 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P27708
- Protein
- CAD protein
- EC
- 2.1.3.2, 3.5.1.2, 3.5.2.3, 6.3.4.16, 6.3.5.5
- Experimental structures
- 85
- Predicted models
- 0
- Ligands
- 8
- Pockets
- 76 · 17 records with a druggable one
Structures
85 records of P27708 in the MolNFT archive: 85 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BY3 | Crystal structure of the dihydroorotase domain of human CAD in apo- form obtained recombinantly… | x-ray diffraction | A | — | — |
| 4BY3 | Crystal structure of the dihydroorotase domain of human cad in apo-form obtained recombinantly from… | x-ray diffraction | A | — | — |
| 4C6B | Crystal structure of the dihydroorotase domain of human CAD with incomplete active site, obtained… | x-ray diffraction | A | — | — |
| 4C6B | Crystal structure of the dihydroorotase domain of human cad with incomplete active site, obtained… | x-ray diffraction | A | — | — |
| 4C6C | Crystal structure of the dihydroorotase domain of human CAD in apo- form obtained recombinantly… | x-ray diffraction | A | — | — |
| 4C6C | Crystal structure of the dihydroorotase domain of human cad in apo-form obtained recombinantly from… | x-ray diffraction | A | — | — |
| 4C6D | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 6.0 | x-ray diffraction | A | — | — |
| 4C6D | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 6.0 | x-ray diffraction | A | — | — |
| 4C6E | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 5.5 | x-ray diffraction | A | — | — |
| 4C6E | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 5.5 | x-ray diffraction | A | — | — |
| 4C6F | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 6.5 | x-ray diffraction | A | — | — |
| 4C6F | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 6.5 | x-ray diffraction | A | — | — |
| 4C6I | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 7.0 | x-ray diffraction | A | — | — |
| 4C6I | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 7.0 | x-ray diffraction | A | — | — |
| 4C6J | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 7.5 | x-ray diffraction | A | — | — |
| 4C6J | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 7.5 | x-ray diffraction | A | — | — |
| 4C6K | Crystal structure of the dihydroorotase domain of human CAD bound to substrate at pH 8.0 | x-ray diffraction | A | — | — |
| 4C6K | Crystal structure of the dihydroorotase domain of human cad bound to substrate at pH 8.0 | x-ray diffraction | A | — | — |
| 4C6L | Crystal structure of the dihydroorotase domain of human CAD bound to the inhibitor fluoroorotate at… | x-ray diffraction | A | — | — |
| 4C6L | Crystal structure of the dihydroorotase domain of human cad bound to the inhibitor fluoroorotate at… | x-ray diffraction | A | — | — |
| 4C6M | Crystal structure of the dihydroorotase domain of human CAD bound to the inhibitor fluoroorotate at… | x-ray diffraction | A | — | — |
| 4C6M | Crystal structure of the dihydroorotase domain of human cad bound to the inhibitor fluoroorotate at… | x-ray diffraction | A | — | — |
| 4C6N | Crystal structure of the dihydroorotase domain of human CAD E1637T mutant bound to substrate at pH… | x-ray diffraction | A | — | — |
| 4C6N | Crystal structure of the dihydroorotase domain of human cad E1637T mutant bound to substrate at pH… | x-ray diffraction | A | — | — |
| 4C6O | Crystal structure of the dihydroorotase domain of human CAD C1613S mutant in apo-form at pH 6.0 | x-ray diffraction | A | — | — |
| 4C6O | Crystal structure of the dihydroorotase domain of human cad C1613S mutant in apo-form at pH 6.0 | x-ray diffraction | A | — | — |
| 4C6P | Crystal structure of the dihydroorotase domain of human CAD C1613S mutant in apo-form at pH 7.0 | x-ray diffraction | A | — | — |
| 4C6P | Crystal structure of the dihydroorotase domain of human cad C1613S mutant in apo-form at pH 7.0 | x-ray diffraction | A | — | — |
| 4C6Q | Crystal structure of the dihydroorotase domain of human CAD C1613S mutant bound to substrate at pH… | x-ray diffraction | A | — | — |
| 4C6Q | Crystal structure of the dihydroorotase domain of human cad C1613S mutant bound to substrate at pH… | x-ray diffraction | A | — | — |
| 5G1N | Aspartate transcarbamoylase domain of human CAD bound to PALA | x-ray diffraction | A, B, C, D, E, F | PAL | — |
| 5G1N | Aspartate transcarbamoylase domain of human cad bound to pala | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5G1O | Aspartate transcarbamoylase domain of human cad in apo form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5G1P | Aspartate transcarbamoylase domain of human cad bound to carbamoyl phosphate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5YNZ | Crystal structure of the dihydroorotase domain (K1556A) of human CAD | x-ray diffraction | A | ZN | 3 (best 0.62) |
| 5YNZ | Crystal structure of the dihydroorotase domain (K1556A) of human cad | x-ray diffraction | A | ZN | — |
| 6HFD | Human dihydroorotase mutant F1563L apo structure | x-ray diffraction | A | ZN | — |
| 6HFD | Human dihydroorotase mutant F1563L apo structure | x-ray diffraction | A | ZN | — |
| 6HFE | Human dihydroorotase mutant F1563T apo structure | x-ray diffraction | A | ZN | 3 (best 0.62) |
| 6HFE | Human dihydroorotase mutant F1563T apo structure | x-ray diffraction | A | ZN | — |
| 6HFF | Human dihydroorotase mutant F1563Y apo structure | x-ray diffraction | A | ZN | 3 (best 0.64) |
| 6HFF | Human dihydroorotase mutant F1563Y apo structure | x-ray diffraction | A | ZN | — |
| 6HFH | Human dihydroorotase mutant F1563A co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, DOR | — |
| 6HFI | Human dihydroorotase mutant F1563A apo structure | x-ray diffraction | A | ZN | 3 (best 0.65) |
| 6HFI | Human dihydroorotase mutant F1563A apo structure | x-ray diffraction | A | ZN | — |
| 6HFJ | Human dihydroorotase mutant F1563A co-crystallized with carbamoyl aspartate at pH 7.5 | x-ray diffraction | A | ZN, DOR | — |
| 6HFK | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 6.5 | x-ray diffraction | A | ZN, DOR | 3 (best 0.62) |
| 6HFK | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 6.5 | x-ray diffraction | A | ZN, DOR | — |
| 6HFL | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, DOR | 3 (best 0.62) |
| 6HFL | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, DOR | — |
| 6HFN | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.5 | x-ray diffraction | A | ZN, DOR | 3 (best 0.63) |
| 6HFN | Human dihydroorotase mutant F1563L co-crystallized with carbamoyl aspartate at pH 7.5 | x-ray diffraction | A | ZN, DOR | — |
| 6HFP | Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, DOR | 3 (best 0.61) |
| 6HFP | Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, DOR | — |
| 6HFQ | Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.5 | x-ray diffraction | A | ZN, DOR | — |
| 6HFQ | Human dihydroorotase mutant F1563T co-crystallized with carbamoyl aspartate at pH 7.5 | x-ray diffraction | A | ZN, DOR | — |
| 6HFR | Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, NCD | 2 (best 0.39) |
| 6HFR | Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 7.0 | x-ray diffraction | A | ZN, NCD | — |
| 6HFS | Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 6.5 | x-ray diffraction | A | ZN, NCD | — |
| 6HFS | Human dihydroorotase mutant F1563Y co-crystallized with carbamoyl aspartate at pH 6.5 | x-ray diffraction | A | ZN, NCD | — |
25 records more on the page itself.
Ligands
- ZN · Zinc ion · in 50 records
- DOR · (4S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid · in 17 records
- NCD · N-carbamoyl-L-aspartate · in 12 records
- FOT · 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid · in 7 records
- NA · Sodium ion · in 3 records
- LMR · (2S)-2-hydroxybutanedioic acid · in 1 record
- PAL · N-(phosphonacetyl)-L-aspartic acid · in 1 record
- URF · 5-fluorouracil · in 1 record
Elsewhere
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