UniProt P27695
DNA-(apurinic or apyrimidinic site) lyase (P27695)
DNA-(apurinic or apyrimidinic site) lyase (UniProt P27695), EC 3.1.-.-, 4.2.99.18: 95 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 138 pockets. Binding sites, druggability and experiment against…
- UniProt
- P27695
- Protein
- DNA-(apurinic or apyrimidinic site) lyase
- EC
- 3.1.-.-, 4.2.99.18
- Experimental structures
- 95
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 138 · 15 records with a druggable one
Structures
96 records of P27695 in the MolNFT archive: 95 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BIX | The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of… | x-ray diffraction | A | — | — |
| 1BIX | The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of… | x-ray diffraction | A | — | — |
| 1CQG | High resolution solution NMR structure of mixed disulfide intermediate between human thioredoxin… | solution nmr | B | — | — |
| 1CQG | High resolution solution NMR structure of mixed disulfide intermediate between human thioredoxin… | solution nmr | B | — | — |
| 1CQH | High resolution solution NMR structure of mixed disulfide intermediate between human thioredoxin… | solution nmr | B | — | — |
| 1CQH | High resolution solution NMR structure of mixed disulfide intermediate between human thioredoxin… | solution nmr | B | — | — |
| 1DE8 | Human APURINIC/APYRIMIDINIC endonuclease-1 (APE1) bound to abasic DNA | x-ray diffraction | B, A | — | — |
| 1DE8 | Human APURINIC/APYRIMIDINIC endonuclease-1 (APE1) bound to abasic DNA | x-ray diffraction | B, A | — | — |
| 1DE9 | Human APE1 endonuclease with bound abasic DNA and MN2+ ion | x-ray diffraction | A, B | — | — |
| 1DE9 | Human APE1 endonuclease with bound abasic DNA and MN2+ ion | x-ray diffraction | A, B | — | — |
| 1DEW | Crystal structure of human APE1 bound to abasic DNA | x-ray diffraction | A, B | — | — |
| 1DEW | Crystal structure of human APE1 bound to abasic DNA | x-ray diffraction | A, B | — | — |
| 1E9N | A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic… | x-ray diffraction | A, B | — | — |
| 1E9N | A second divalent metal ion in the active site of a new crystal form of human APURINIC/APYRIMIDINIC… | x-ray diffraction | A, B | — | — |
| 1HD7 | A Second Divalent Metal Ion in the Active Site of a New Crystal Form of Human Apurinic/Apyridinimic… | x-ray diffraction | A | — | — |
| 1HD7 | A second divalent metal ion in the active site of a new crystal form of human APURINIC/APYRIDINIMIC… | x-ray diffraction | A | — | — |
| 2ISI | Crystal structure of Ape1 from Homo sapiens in a new crystal form complexed with a ligand | x-ray diffraction | A, B, C | — | — |
| 2ISI | Crystal structure of APE1 from homo sapiens in a new crystal form complexed with a ligand | x-ray diffraction | A, B, C | — | — |
| 2O3H | Crystal structure of the human C65A Ape | x-ray diffraction | A | — | — |
| 2O3H | Crystal structure of the human C65A ape | x-ray diffraction | A | — | — |
| 3U8U | Crystal structure of Human Apurinic/Apyridinimic Endonuclease, Ape1 in a new crystal form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3U8U | Crystal structure of human APURINIC/APYRIDINIMIC endonuclease, APE1 in a new crystal form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IEM | Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ | x-ray diffraction | A, B, C, D | — | — |
| 4IEM | Human APURINIC/APYRIMIDINIC endonuclease (APE1) with product DNA and MG2+ | x-ray diffraction | A, B, C, D | — | — |
| 4LND | Crystal structure of human apurinic/apyrimidinic endonuclease 1 with essential Mg2+ cofactor | x-ray diffraction | A, B, C | — | — |
| 4LND | Crystal structure of human APURINIC/APYRIMIDINIC endonuclease 1 with essential MG2+ cofactor | x-ray diffraction | A, B, C | — | — |
| 4QH9 | Crystal structure of Mn2+ bound human APE1 | x-ray diffraction | A | — | — |
| 4QH9 | Crystal structure of MN2+ bound human APE1 | x-ray diffraction | A | — | — |
| 4QHD | Crystal structure of apo human APE1 | x-ray diffraction | A | — | — |
| 4QHD | Crystal structure of apo human APE1 | x-ray diffraction | A | — | — |
| 4QHE | Crystal structure of Mg2+ bound human APE1 | x-ray diffraction | A | — | — |
| 4QHE | Crystal structure of MG2+ bound human APE1 | x-ray diffraction | A | — | — |
| 5CFG | C2 crystal form of APE1 with Mg2+ | x-ray diffraction | A | MG | 2 (best 0.46) |
| 5CFG | C2 crystal form of APE1 with MG2+ | x-ray diffraction | A | — | — |
| 5DFF | Human APE1 product complex | x-ray diffraction | A, B | MG, CL | 9 (best 0.68) |
| 5DFF | Human APE1 product complex | x-ray diffraction | A, B | — | — |
| 5DFH | Human APE1 mismatch product complex | x-ray diffraction | A, B | — | — |
| 5DFI | Human APE1 phosphorothioate substrate complex | x-ray diffraction | A, B | — | — |
| 5DFJ | Human APE1 E96Q/D210N mismatch substrate complex | x-ray diffraction | A, B | — | — |
| 5DG0 | Human APE1 phosphorothioate substrate complex with Mn2+ | x-ray diffraction | A, B | MN, CL | 7 (best 0.66) |
| 5DG0 | Human APE1 phosphorothioate substrate complex with MN2+ | x-ray diffraction | A, B | — | — |
| 5WN0 | APE1 exonuclease substrate complex with a C/G match | x-ray diffraction | A, B | — | — |
| 5WN1 | APE1 exonuclease product complex | x-ray diffraction | A, B | CL, NA | — |
| 5WN2 | APE1 exonuclease substrate complex with phosphoglycolate | x-ray diffraction | A, B | NA, PGA | — |
| 5WN2 | APE1 exonuclease substrate complex with phosphoglycolate | x-ray diffraction | A, B | NA, PGA | — |
| 5WN3 | APE1 F266A exonuclease substrate complex with a C/T mismatch | x-ray diffraction | A, B | NA, CL | — |
| 5WN4 | APE1 exonuclease substrate complex with a C/T mismatch | x-ray diffraction | A, B | NA, CL | 9 (best 0.51) |
| 5WN5 | APE1 exonuclease substrate complex with a C/T mismatch and MN2+ | x-ray diffraction | A, B | NA, MN | — |
| 6BOQ | Human APE1 substrate complex with an A/A mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
| 6BOR | Human APE1 substrate complex with an G/G mismatch adjacent the THF | x-ray diffraction | A, B | CL | 9 (best 0.66) |
| 6BOR | Human APE1 substrate complex with an G/G mismatch adjacent the thf | x-ray diffraction | A, B | CL | — |
| 6BOS | Human APE1 substrate complex with an A/C mismatch adjacent the THF | x-ray diffraction | A, B | — | — |
| 6BOS | Human APE1 substrate complex with an A/C mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
| 6BOT | Human APE1 substrate complex with an C/C mismatch adjacent the THF | x-ray diffraction | A, B | — | — |
| 6BOT | Human APE1 substrate complex with an C/C mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
| 6BOU | Human APE1 substrate complex with an T/C mismatch adjacent the THF | x-ray diffraction | A, B | — | 8 (best 0.60) |
| 6BOU | Human APE1 substrate complex with an T/C mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
| 6BOV | Human APE1 substrate complex with an A/G mismatch adjacent the THF | x-ray diffraction | A, B | — | 6 (best 0.69) |
| 6BOV | Human APE1 substrate complex with an A/G mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
| 6BOW | Human APE1 substrate complex with an T/T mismatch adjacent the thf | x-ray diffraction | A, B | — | — |
36 records more on the page itself.
Ligands
Experiment against prediction
- 5WN3 chain B against the predicted model P27695: TM-score 1.00, RMSD 0.26 Å
- 5WN2 chain B against the predicted model P27695: TM-score 1.00, RMSD 0.27 Å
- 5WN2 chain B against the predicted model P27695: TM-score 1.00, RMSD 0.27 Å
- 5DFH chain B against the predicted model P27695: TM-score 1.00, RMSD 0.28 Å
- 6W3U chain B against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
- 6W3U chain B against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
- 5WN5 chain A against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
- 5WN2 chain A against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
- 5WN2 chain A against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
- 6W0Q chain B against the predicted model P27695: TM-score 1.00, RMSD 0.29 Å
Elsewhere
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