UniProt P24863
Cyclin-C (P24863)
Cyclin-C (UniProt P24863): 65 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 386 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P24863
- Protein
- Cyclin-C
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 386 · 66 records with a druggable one
Structures
66 records of P24863 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RGF | Crystal Structure of human CDK8/CycC | x-ray diffraction | B | — | 5 (best 0.58) |
| 3RGF | Crystal structure of human CDK8/CYCC | x-ray diffraction | B | — | 5 (best 0.58) |
| 4CRL | Crystal structure of human CDK8-Cyclin C in complex with cortistatin A | x-ray diffraction | B | — | 6 (best 0.61) |
| 4CRL | Crystal structure of human CDK8-cyclin C in complex with cortistatin a | x-ray diffraction | B | — | 6 (best 0.61) |
| 4F6S | Crystal structure of human CDK8/CYCC in complex with compound 7… | x-ray diffraction | B | — | 6 (best 0.71) |
| 4F6S | Crystal structure of human CDK8/CYCC in complex with compound 7 (1-[3… | x-ray diffraction | B | — | 6 (best 0.71) |
| 4F6U | Crystal structure of human CDK8/CYCC in complex with compound 5… | x-ray diffraction | B | — | 6 (best 0.69) |
| 4F6U | Crystal structure of human CDK8/CYCC in complex with compound 5 (1-[3… | x-ray diffraction | B | — | 6 (best 0.69) |
| 4F6W | Crystal structure of human CDK8/CYCC in complex with compound 1… | x-ray diffraction | B | — | 6 (best 0.67) |
| 4F6W | Crystal structure of human CDK8/CYCC in complex with compound 1 (N-[3… | x-ray diffraction | B | — | 6 (best 0.67) |
| 4F70 | Crystal structure of human CDK8/CYCC in complex with compound 4… | x-ray diffraction | B | — | 6 (best 0.72) |
| 4F70 | Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3… | x-ray diffraction | B | — | 6 (best 0.72) |
| 4F7J | Crystal structure of human CDK8/CYCC in complex with compound 3… | x-ray diffraction | B | — | 6 (best 0.66) |
| 4F7J | Crystal structure of human CDK8/CYCC in complex with compound 3 (1-[3… | x-ray diffraction | B | — | 6 (best 0.66) |
| 4F7L | Crystal structure of human CDK8/CYCC in complex with compound 2 (tert-butyl… | x-ray diffraction | B | — | 6 (best 0.71) |
| 4F7L | Crystal structure of human CDK8/CYCC in complex with compound 2 (tert- butyl… | x-ray diffraction | B | — | 6 (best 0.71) |
| 4F7N | Crystal structure of human CDK8/CYCC in complex with compound 11… | x-ray diffraction | B | — | 6 (best 0.74) |
| 4F7N | Crystal structure of human CDK8/CYCC in complex with compound 11 (1… | x-ray diffraction | B | — | 6 (best 0.74) |
| 4F7S | Crystal structure of human CDK8/CYCC in the DMG-in conformation | x-ray diffraction | B | — | 6 (best 0.64) |
| 4F7S | Crystal structure of human CDK8/CYCC in the dmg-in conformation | x-ray diffraction | B | — | 6 (best 0.64) |
| 4G6L | Crystal structure of human CDK8/CYCC in the DMG-in conformation | x-ray diffraction | B | — | 5 (best 0.72) |
| 4G6L | Crystal structure of human CDK8/CYCC in the dmg-in conformation | x-ray diffraction | B | — | 5 (best 0.72) |
| 5BNJ | CDK8/CYCC IN COMPLEX WITH 8-{3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)-phenyl]-pyridin… | x-ray diffraction | B | — | 5 (best 0.69) |
| 5BNJ | CDK8/CYCC in complex with 8-{3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)- phenyl]-pyridin… | x-ray diffraction | B | — | 5 (best 0.69) |
| 5CEI | Crystal structure of CDK8:Cyclin C complex with compound 22 | x-ray diffraction | B | — | 6 (best 0.60) |
| 5CEI | Crystal structure of CDK8:CYCLIN C complex with compound 22 | x-ray diffraction | B | — | 6 (best 0.60) |
| 5FGK | CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro… | x-ray diffraction | B | — | 6 (best 0.63) |
| 5FGK | CDK8-cycc in complex with 8-[3-(3-amino-1H-indazol-6-yl)-5-chloro… | x-ray diffraction | B | — | 6 (best 0.63) |
| 5HBE | CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2… | x-ray diffraction | B | — | 5 (best 0.69) |
| 5HBE | CDK8-cycc in complex with 8-[3-chloro-5-(1-methyl-2,2-dioxo-2, 3… | x-ray diffraction | B | — | 5 (best 0.69) |
| 5HBH | CDK8-CYCC IN COMPLEX WITH 5-{5-Chloro-4-[1-(2-methoxy-ethyl)-1,8-diaza-spiro[4.5]dec-8-yl]-pyridin-3… | x-ray diffraction | B | — | 8 (best 0.57) |
| 5HBH | CDK8-cycc in complex with 5-{5-chloro-4-[1-(2-methoxy-ethyl)-1,8… | x-ray diffraction | B | — | 8 (best 0.57) |
| 5HBJ | CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-s… | x-ray diffraction | B | — | 8 (best 0.74) |
| 5HBJ | CDK8-cycc in complex with 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol… | x-ray diffraction | B | — | 8 (best 0.74) |
| 5HNB | CDK8-CYCC IN COMPLEX WITH [6-Hydroxy-3-(3-methyl-benzyl)-1H-indazol-5-yl]-((S)-3-hydroxy-pyrrolidin… | x-ray diffraction | B | — | 5 (best 0.71) |
| 5HNB | CDK8-cycc in complex with [6-hydroxy-3-(3-methyl-benzyl)-1H-indazol-5… | x-ray diffraction | B | — | 5 (best 0.71) |
| 5HVY | CDK8/CYCC in complex with compound 20 | x-ray diffraction | B | CL | 7 (best 0.75) |
| 5HVY | CDK8/CYCC in complex with compound 20 | x-ray diffraction | B | CL | 7 (best 0.75) |
| 5I5Z | CDK8-CYCC IN COMPLEX WITH 8-(1-Methyl-2,2-dioxo-2,3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-[1,6]nap… | x-ray diffraction | B | — | 5 (best 0.71) |
| 5I5Z | CDK8-cycc in complex with 8-(1-methyl-2,2-dioxo-2,3-dihydro-1H-2L6… | x-ray diffraction | B | — | 5 (best 0.71) |
| 5ICP | CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(5-methyl-imidazo[5,1-b][1,3,4]t… | x-ray diffraction | B | — | 8 (best 0.60) |
| 5ICP | CDK8-cycc in complex with [(S)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]… | x-ray diffraction | B | — | 8 (best 0.60) |
| 5IDN | CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyri… | x-ray diffraction | B | — | 6 (best 0.67) |
| 5IDN | CDK8-cycc in complex with [(S)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]… | x-ray diffraction | B | — | 6 (best 0.67) |
| 5IDP | CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-metha | x-ray diffraction | B | — | 5 (best 0.71) |
| 5IDP | CDK8-cycc in complex with (3-amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro… | x-ray diffraction | B | — | 5 (best 0.71) |
| 5XQX | Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide | x-ray diffraction | B | — | 5 (best 0.63) |
| 5XQX | Human CDK8-cycc in complex with compound 4: N-methyl-4-(4-pyridyl)-1H- pyrrole-2-carboxamide | x-ray diffraction | B | — | 5 (best 0.63) |
| 5XS2 | CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-chloro-4-(4-pyridyl)-1H-pyrrole-2-carboxamide | x-ray diffraction | B | — | 5 (best 0.63) |
| 5XS2 | CDK8-cycc in complex with compound 17:3-chloro-4-(4-pyridyl)-1H- pyrrole-2-carboxamide | x-ray diffraction | B | — | 5 (best 0.63) |
| 6QTG | Crystal structure of human CDK8/CYCC in complex with BI-1347 | x-ray diffraction | B | — | 6 (best 0.60) |
| 6QTG | Crystal structure of human CDK8/CYCC in complex with bi-1347 | x-ray diffraction | B | — | 6 (best 0.60) |
| 6QTJ | Crystal structure of human CDK8/CYCC in complex with BI 919811 | x-ray diffraction | B | — | 6 (best 0.59) |
| 6QTJ | Crystal structure of human CDK8/CYCC in complex with bi 919811 | x-ray diffraction | B | — | 6 (best 0.59) |
| 6R3S | CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 | x-ray diffraction | B | — | 7 (best 0.71) |
| 6R3S | Crystal structure of CDK8-cycc in complex with compound 1 | x-ray diffraction | B | — | 7 (best 0.71) |
| 6T41 | CDK8/Cyclin C in complex with N-(4-chlorobenzyl)isoquinolin-4-amine | x-ray diffraction | B | — | 7 (best 0.71) |
| 6T41 | CDK8/CYCLIN C in complex with N-(4-CHLOROBENZYL)ISOQUINOLIN-4-amine | x-ray diffraction | B | — | 7 (best 0.71) |
| 6TPA | CDK8/CyclinC in complex with drug ETP-50775 | x-ray diffraction | B | NZ5 | 5 (best 0.59) |
| 6TPA | CDK8/CYCLINC in complex with drug etp-50775 | x-ray diffraction | B | NZ5 | 5 (best 0.59) |
6 records more on the page itself.
Ligands
Experiment against prediction
- 5XS2 chain B against the predicted model P24863: TM-score 1.00, RMSD 0.39 Å
- 5XS2 chain B against the predicted model P24863: TM-score 1.00, RMSD 0.39 Å
- 5XQX chain B against the predicted model P24863: TM-score 1.00, RMSD 0.40 Å
- 5XQX chain B against the predicted model P24863: TM-score 1.00, RMSD 0.40 Å
- 6QTG chain B against the predicted model P24863: TM-score 0.99, RMSD 0.46 Å
- 6QTG chain B against the predicted model P24863: TM-score 0.99, RMSD 0.46 Å
- 6QTJ chain B against the predicted model P24863: TM-score 0.99, RMSD 0.47 Å
- 6QTJ chain B against the predicted model P24863: TM-score 0.99, RMSD 0.47 Å
- 4CRL chain B against the predicted model P24863: TM-score 0.99, RMSD 0.36 Å
- 4CRL chain B against the predicted model P24863: TM-score 0.99, RMSD 0.36 Å
Elsewhere
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