MolNFT v1 · #162264 · protein
Crystal structure of CDK8-cycc in complex with compound 1
6R3S: “Crystal structure of CDK8-cycc in complex with compound 1”. X-ray diffraction, 1 ligand (JRE). MolNFT v1 #162264 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6R3S
- Type
- protein
- Length
- 613 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P49336, P24863
- Ligands
- JRE
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 346 | — | P49336 |
| B | — | protein | 267 | — | P24863 |
Ligands and binding sites
- JRE · 6-[5-chloranyl-4-[(1~{S})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide · ligand · chains A
- FMT · Formic acid · additive · 3 copies · chains B, A
- EDO · 1,2-ethanediol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6R3S · CRYSTAL STRUCTURE OF CDK8-CycC IN COMPLEX WITH COMPOUND 1 · the same entry in another collection · chain A against A, TM-score 1.00
- P24863 · AlphaFold monomer V2.0 prediction for cyclin-C (P24863) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P49336 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 8 (P49336) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49336
- Every structure of UniProt P24863
- Elsewhere: RCSB PDB 6R3S · PDBe 6R3S · UniProt P49336 · UniProt P24863
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.