UniProt P23141
Liver carboxylesterase 1 (P23141)
Liver carboxylesterase 1 (UniProt P23141), EC 3.1.1.1, 3.1.1.13: 32 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P23141
- Protein
- Liver carboxylesterase 1
- EC
- 3.1.1.1, 3.1.1.13, 3.1.1.56
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 23 · 2 records with a druggable one
Structures
33 records of P23141 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MX1 | Crystal Structure of Human Liver Carboxylesterase in complex with tacrine | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1MX1 | Crystal structure of human liver carboxylesterase in complex with tacrine | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1MX5 | Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1MX5 | Crystal structure of human liver carboxylesterase in complexed with homatropine, a cocaine analogue | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1MX9 | Crystal Structure of Human Liver Carboxylesterase in complexed with naloxone methiodide, a heroin… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1MX9 | Crystal structure of human liver carboxylesterase in complexed with naloxone methiodide, a heroin… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1YA4 | Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen | x-ray diffraction | A, B, C | — | — |
| 1YA4 | Crystal structure of human liver carboxylesterase 1 in complex with tamoxifen | x-ray diffraction | A, B, C | — | — |
| 1YA8 | Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin | x-ray diffraction | A, B, C | — | — |
| 1YA8 | Crystal structure of human liver carboxylesterase in complex with cleavage products of mevastatin | x-ray diffraction | A, B, C | — | — |
| 1YAH | Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl… | x-ray diffraction | A, B, C | — | — |
| 1YAH | Crystal structure of human liver carboxylesterase complexed to etyl acetate; a fatty acid ethyl… | x-ray diffraction | A, B, C | — | — |
| 1YAJ | Crystal Structure of Human Liver Carboxylesterase in complex with benzil | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1YAJ | Crystal structure of human liver carboxylesterase in complex with benzil | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 2DQY | Crystal structure of human carboxylesterase in complex with cholate and palmitate | x-ray diffraction | A, B, C | — | — |
| 2DQY | Crystal structure of human carboxylesterase in complex with cholate and palmitate | x-ray diffraction | A, B, C | — | — |
| 2DQZ | Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate | x-ray diffraction | A, B, C | — | — |
| 2DQZ | Crystal structure of human carboxylesterase in complex with homatropine, coenzyme a, and palmitate | x-ray diffraction | A, B, C | — | — |
| 2DR0 | Crystal structure of human carboxylesterase in complex with taurocholate | x-ray diffraction | A, B, C | — | — |
| 2DR0 | Crystal structure of human carboxylesterase in complex with taurocholate | x-ray diffraction | A, B, C | — | — |
| 2H7C | Crystal structure of human carboxylesterase in complex with Coenzyme A | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2H7C | Crystal structure of human carboxylesterase in complex with coenzyme a | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3K9B | Crystal structure of human liver carboxylesterase 1 (hCE1) in covalent complex with the nerve agent… | x-ray diffraction | A, B, C | — | — |
| 3K9B | Crystal structure of human liver carboxylesterase 1 (HCE1) in covalent complex with the nerve agent… | x-ray diffraction | A, B, C | — | — |
| 4AB1 | Recombinant Human Carboxylesterase 1 from whole Cabbage Loopers | x-ray diffraction | A | — | — |
| 4AB1 | Recombinant human carboxylesterase 1 from whole cabbage loopers | x-ray diffraction | A | — | — |
| 5A7F | Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1 | x-ray diffraction | — | — | |
| 5A7G | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 | x-ray diffraction | A | NAG | 4 (best 0.80) |
| 5A7G | Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1 | x-ray diffraction | A | — | — |
| 5A7H | Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 | x-ray diffraction | A | — | — |
| 5A7H | Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1 | x-ray diffraction | A | — | — |
| 8EOR | Liver carboxylesterase 1 | electron microscopy | A, B, C | NAG, EEE | 19 (best 0.81) |
| P23141 | AlphaFold monomer V2.0 prediction for liver carboxylesterase 1 (P23141) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2H7C chain E against the predicted model P23141: TM-score 1.00, RMSD 0.34 Å
- 2H7C chain E against the predicted model P23141: TM-score 1.00, RMSD 0.34 Å
- 1MX1 chain E against the predicted model P23141: TM-score 1.00, RMSD 0.35 Å
- 1MX1 chain E against the predicted model P23141: TM-score 1.00, RMSD 0.35 Å
- 3K9B chain C against the predicted model P23141: TM-score 1.00, RMSD 0.33 Å
- 3K9B chain C against the predicted model P23141: TM-score 1.00, RMSD 0.33 Å
- 2H7C chain F against the predicted model P23141: TM-score 1.00, RMSD 0.35 Å
- 2H7C chain F against the predicted model P23141: TM-score 1.00, RMSD 0.35 Å
- 1MX1 chain D against the predicted model P23141: TM-score 1.00, RMSD 0.36 Å
- 1MX1 chain D against the predicted model P23141: TM-score 1.00, RMSD 0.36 Å
Elsewhere
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