UniProt P22985
Xanthine dehydrogenase/oxidase (P22985)
Xanthine dehydrogenase/oxidase (UniProt P22985), EC 1.1.1.204, 1.1.3.22: 28 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 133 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22985
- Protein
- Xanthine dehydrogenase/oxidase
- EC
- 1.1.1.204, 1.1.3.22, 1.17.1.4, 1.17.3.2
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 133 · 7 records with a druggable one
Structures
29 records of P22985 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WYG | Crystal Structure of a Rat Xanthine Dehydrogenase Triple Mutant (C535A, C992R and C1324S) | x-ray diffraction | A | PO4, CA, FES, FAD, SAL | 16 (best 0.82) |
| 1WYG | Crystal structure of a rat xanthine dehydrogenase triple mutant (C535A, C992R and C1324S) | x-ray diffraction | A | — | — |
| 2E3T | Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L) | x-ray diffraction | A, B | — | — |
| 2E3T | Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L) | x-ray diffraction | A, B | — | — |
| 3AN1 | Crystal structure of rat D428A mutant, urate bound form | x-ray diffraction | A, B | — | — |
| 3AN1 | Crystal structure of rat D428A mutant, urate bound form | x-ray diffraction | A, B | — | — |
| 4YRW | rat xanthine oxidoreductase, C-terminal deletion protein variant | x-ray diffraction | A, B | — | — |
| 4YRW | Rat xanthine oxidoreductase, C-terminal deletion protein variant | x-ray diffraction | A, B | — | — |
| 4YSW | Structure of rat xanthine oxidoreductase, C-terminal deletion protein variant, NADH bound form | x-ray diffraction | A, B | — | — |
| 4YSW | Structure of rat xanthine oxidoreductase, C-terminal deletion protein variant, NADH bound form | x-ray diffraction | A, B | — | — |
| 4YTY | Structure of rat xanthine oxidoreductase, C535A/C992R/C1324S, NADH bound form | x-ray diffraction | A, B | — | — |
| 4YTY | Structure of rat xanthine oxidoreductase, C535A/C992R/C1324S, NADH bound form | x-ray diffraction | A, B | — | — |
| 4YTZ | Rat xanthine oxidoreductase, C-terminal deletion protein variant, crystal grown without… | x-ray diffraction | A, B | — | — |
| 4YTZ | Rat xanthine oxidoreductase, C-terminal deletion protein variant, crystal grown without… | x-ray diffraction | A, B | — | — |
| 6A7X | Rat Xanthine oxidoreductase, D428A variant, NAD bound form | x-ray diffraction | A, B | NAD, URC, BCT, FES, FAD | 20 (best 0.85) |
| 6A7X | Rat xanthine oxidoreductase, D428A variant, NAD bound form | x-ray diffraction | A, B | NAD, URC, BCT, FES, FAD | — |
| 6ABU | Rat Xanthine oxidoreductase, NAD bound form | x-ray diffraction | A, B | NAD, URC, BCT, FES, FAD | 20 (best 0.85) |
| 6ABU | Rat xanthine oxidoreductase, NAD bound form | x-ray diffraction | A, B | NAD, URC, BCT, FES, FAD | — |
| 6AC1 | Rat Xanthine oxidoreductase, NADH bound form | x-ray diffraction | A, B | URC, BCT, FES, FAD, NAI | — |
| 6AC1 | Rat xanthine oxidoreductase, NADH bound form | x-ray diffraction | A, B | URC, BCT, FES, FAD, NAI | — |
| 6AC4 | Rat Xanthine oxidoreductase, D428N variant | x-ray diffraction | A, B | FAD, FES | — |
| 6AC4 | Rat xanthine oxidoreductase, D428N variant | x-ray diffraction | A, B | FAD, FES | — |
| 6AD4 | Rat Xanthine oxidoreductase, D428A variant, NADH bound form | x-ray diffraction | A, B | URC, BCT, FES, FAD, NAI | 20 (best 0.90) |
| 6AD4 | Rat xanthine oxidoreductase, D428A variant, NADH bound form | x-ray diffraction | A, B | URC, BCT, FES, FAD, NAI | — |
| 6ADJ | Rat Xanthine oxidoreductase, D428E variant | x-ray diffraction | A, B | FES, CA, FAD | 20 (best 0.89) |
| 6ADJ | Rat xanthine oxidoreductase, D428E variant | x-ray diffraction | A, B | FES, CA, FAD | — |
| 6AJU | Rat Xanthine oxidoreductase | x-ray diffraction | A, F | FES, URC, BCT, FAD | 20 (best 0.86) |
| 6AJU | Rat xanthine oxidoreductase | x-ray diffraction | A, F | FES, URC, BCT, FAD | — |
| P22985 | AlphaFold monomer V2.0 prediction for xanthine DEHYDROGENASE/OXIDASE (P22985) | predicted | A | — | 17 (best 0.83) |
Ligands
- FAD · Flavin-adenine dinucleotide · in 15 records
- FES · Fe2/s2 (inorganic) cluster · in 15 records
- BCT · Bicarbonate ion · in 10 records
- URC · Uric acid · in 10 records
- NAD · Nicotinamide-adenine-dinucleotide · in 4 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 4 records
- CA · Calcium ion · in 3 records
- PO4 · Phosphate ion · in 1 record
- SAL · 2-hydroxybenzoic acid · in 1 record
Experiment against prediction
- 6A7X chain A against the predicted model P22985: TM-score 1.00, RMSD 0.46 Å
- 6A7X chain A against the predicted model P22985: TM-score 1.00, RMSD 0.46 Å
- 6AC1 chain A against the predicted model P22985: TM-score 1.00, RMSD 0.49 Å
- 6AC1 chain A against the predicted model P22985: TM-score 1.00, RMSD 0.49 Å
- 4YTY chain A against the predicted model P22985: TM-score 1.00, RMSD 0.52 Å
- 4YTY chain A against the predicted model P22985: TM-score 1.00, RMSD 0.52 Å
- 3AN1 chain A against the predicted model P22985: TM-score 1.00, RMSD 0.58 Å
- 3AN1 chain A against the predicted model P22985: TM-score 1.00, RMSD 0.58 Å
- 6ADJ chain A against the predicted model P22985: TM-score 1.00, RMSD 0.59 Å
- 6ADJ chain A against the predicted model P22985: TM-score 1.00, RMSD 0.59 Å
Elsewhere
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