UniProt P22914
Gamma-crystallin S (P22914)
Gamma-crystallin S (UniProt P22914): 20 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22914
- Protein
- Gamma-crystallin S
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
21 records of P22914 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HA4 | GammaS crystallin C terminal domain from Homo Sapiens | x-ray diffraction | A, B | — | — |
| 1HA4 | Gammas crystallin C terminal domain from homo sapiens | x-ray diffraction | A, B | — | — |
| 2M3T | Solution-state NMR structure of wild-type human gamma(S)-crystallin | solution nmr | A | — | — |
| 2M3T | Solution-state NMR structure of wild-type human GAMMA(S)-crystallin | solution nmr | A | — | — |
| 2M3U | Solution-state NMR structure of cataract-related human gamma(S)-crystallin point variant G18V | solution nmr | A | — | — |
| 2M3U | Solution-state NMR structure of cataract-related human GAMMA(S)- crystallin point variant G18V | solution nmr | A | — | — |
| 6FD8 | Gamma-s crystallin dimer | x-ray diffraction | A, B | — | 3 (best 0.79) |
| 6FD8 | Gamma-S crystallin dimer | x-ray diffraction | A, B | — | — |
| 6IF9 | Solution-state NMR structure of G57W human gammas crystallin | solution nmr | A | — | — |
| 7N36 | Crystal structure of wild-type human GAMMA(S)-crystallin | x-ray diffraction | A, B | — | — |
| 7N37 | Crystal structure of 3-site deamidated variant of human gamma(S)-crystallin | x-ray diffraction | A | MG | — |
| 7N37 | Crystal structure of 3-site deamidated variant of human GAMMA(S)- crystallin | x-ray diffraction | A | — | — |
| 7N38 | Crystal structure of 5-site deamidated variant of human gamma(S)-crystallin | x-ray diffraction | A | MG | 1 (best 0.30) |
| 7N38 | Crystal structure of 5-site deamidated variant of human GAMMA(S)- crystallin | x-ray diffraction | A | MG | — |
| 7N39 | Crystal structure of 7-site deamidated variant of human GAMMA(S)- crystallin | x-ray diffraction | A, B | SO4 | — |
| 7N3A | Crystal structure of 9-site deamidated variant of human gamma(S)-crystallin | x-ray diffraction | A | — | 1 (best 0.33) |
| 7N3A | Crystal structure of 9-site deamidated variant of human GAMMA(S)- crystallin | x-ray diffraction | A | — | — |
| 7N3B | Crystal structure of aged 9-site deamidated variant of human gamma(S)-crystallin | x-ray diffraction | A, B | — | 2 (best 0.60) |
| 7N3B | Crystal structure of aged 9-site deamidated variant of human GAMMA(S)- crystallin | x-ray diffraction | A, B | — | — |
| 7NJE | GAMMA(S)-crystallin 9-site deamidation mutant grown inside hare serial crystallography chip | x-ray diffraction | A, B | — | — |
| P22914 | AlphaFold monomer V2.0 prediction for gamma-crystallin S (P22914) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7N39 chain B against the predicted model P22914: TM-score 0.99, RMSD 0.37 Å
- 7N3B chain A against the predicted model P22914: TM-score 0.99, RMSD 0.39 Å
- 7N3B chain A against the predicted model P22914: TM-score 0.99, RMSD 0.39 Å
- 7N3B chain B against the predicted model P22914: TM-score 0.99, RMSD 0.41 Å
- 7N3B chain B against the predicted model P22914: TM-score 0.99, RMSD 0.41 Å
- 7N39 chain A against the predicted model P22914: TM-score 0.99, RMSD 0.53 Å
- 7NJE chain A against the predicted model P22914: TM-score 0.98, RMSD 0.78 Å
- 6FD8 chain B against the predicted model P22914: TM-score 0.97, RMSD 1.08 Å
- 6FD8 chain B against the predicted model P22914: TM-score 0.97, RMSD 1.08 Å
- 7NJE chain B against the predicted model P22914: TM-score 0.97, RMSD 0.83 Å
Elsewhere
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