MolNFT v1 · #182755 · protein

Crystal structure of 5-site deamidated variant of human GAMMA(S)- crystallin

7N38 · Gamma-crystallin S: “Crystal structure of 5-site deamidated variant of human GAMMA(S)- crystallin”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.30). MolNFT v1 #182755 on GenesisL1: 3D structure, binding sites and…

PDB: 7N38
Type: protein
Length: 174 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma-crystallin S
UniProt: P22914
Ligands: MG
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gamma-crystallin S	protein	174	11% helix, 42% strand	P22914

Ligands and binding sites

MG · Magnesium ion · metal · chains A
BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.30	0.75	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7N38 · Crystal structure of 5-site deamidated variant of human gamma(S)-crystallin · the same entry in another collection · chain A against A, TM-score 1.00
P22914 · AlphaFold monomer V2.0 prediction for gamma-crystallin S (P22914) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22914
Elsewhere: RCSB PDB 7N38 · PDBe 7N38 · UniProt P22914

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