MolNFT v1 · #148666 · protein

Gamma-S crystallin dimer

6FD8 · Beta-crystallin S: “Gamma-S crystallin dimer”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #148666 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6FD8
Type: protein
Length: 348 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-crystallin S
UniProt: P22914
Pockets: 3 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-crystallin S	protein	174	7% helix, 43% strand	P22914

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	505	0.79	0.86	71	empty
2	61	0.33	0.77	15	empty
3	55	0.26	0.73	18	empty

Interfaces

1 interface between chains.

A–B · 1115 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6FD8 · Gamma-s crystallin dimer · the same entry in another collection · chain A against A, TM-score 1.00
P22914 · AlphaFold monomer V2.0 prediction for gamma-crystallin S (P22914) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22914
Elsewhere: RCSB PDB 6FD8 · PDBe 6FD8 · UniProt P22914

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.